Negative symptoms and speech pauses in youths at clinical high risk for psychosis

Aberrant pauses are characteristic of schizophrenia and are robustly associated with its negative symptoms. Here, we found that pause behavior was associated with negative symptoms in individuals at clinical high risk (CHR) for psychosis, and with measures of syntactic complexity—phrase length and u...

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Autores principales: Stanislawski, Emma R., Bilgrami, Zarina R., Sarac, Cansu, Garg, Sahil, Heisig, Stephen, Cecchi, Guillermo A., Agurto, Carla, Corcoran, Cheryl M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822906/
https://www.ncbi.nlm.nih.gov/pubmed/33483485
http://dx.doi.org/10.1038/s41537-020-00132-1
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author Stanislawski, Emma R.
Bilgrami, Zarina R.
Sarac, Cansu
Garg, Sahil
Heisig, Stephen
Cecchi, Guillermo A.
Agurto, Carla
Corcoran, Cheryl M.
author_facet Stanislawski, Emma R.
Bilgrami, Zarina R.
Sarac, Cansu
Garg, Sahil
Heisig, Stephen
Cecchi, Guillermo A.
Agurto, Carla
Corcoran, Cheryl M.
author_sort Stanislawski, Emma R.
collection PubMed
description Aberrant pauses are characteristic of schizophrenia and are robustly associated with its negative symptoms. Here, we found that pause behavior was associated with negative symptoms in individuals at clinical high risk (CHR) for psychosis, and with measures of syntactic complexity—phrase length and usage of determiners that introduce clauses—that we previously showed in this same CHR cohort to help comprise a classifier that predicted psychosis. These findings suggest a common impairment in discourse planning and verbal self-monitoring that affects both speech and language, and which is detected in clinical ratings of negative symptoms.
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spelling pubmed-78229062021-01-29 Negative symptoms and speech pauses in youths at clinical high risk for psychosis Stanislawski, Emma R. Bilgrami, Zarina R. Sarac, Cansu Garg, Sahil Heisig, Stephen Cecchi, Guillermo A. Agurto, Carla Corcoran, Cheryl M. NPJ Schizophr Brief Communication Aberrant pauses are characteristic of schizophrenia and are robustly associated with its negative symptoms. Here, we found that pause behavior was associated with negative symptoms in individuals at clinical high risk (CHR) for psychosis, and with measures of syntactic complexity—phrase length and usage of determiners that introduce clauses—that we previously showed in this same CHR cohort to help comprise a classifier that predicted psychosis. These findings suggest a common impairment in discourse planning and verbal self-monitoring that affects both speech and language, and which is detected in clinical ratings of negative symptoms. Nature Publishing Group UK 2021-01-22 /pmc/articles/PMC7822906/ /pubmed/33483485 http://dx.doi.org/10.1038/s41537-020-00132-1 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Communication
Stanislawski, Emma R.
Bilgrami, Zarina R.
Sarac, Cansu
Garg, Sahil
Heisig, Stephen
Cecchi, Guillermo A.
Agurto, Carla
Corcoran, Cheryl M.
Negative symptoms and speech pauses in youths at clinical high risk for psychosis
title Negative symptoms and speech pauses in youths at clinical high risk for psychosis
title_full Negative symptoms and speech pauses in youths at clinical high risk for psychosis
title_fullStr Negative symptoms and speech pauses in youths at clinical high risk for psychosis
title_full_unstemmed Negative symptoms and speech pauses in youths at clinical high risk for psychosis
title_short Negative symptoms and speech pauses in youths at clinical high risk for psychosis
title_sort negative symptoms and speech pauses in youths at clinical high risk for psychosis
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822906/
https://www.ncbi.nlm.nih.gov/pubmed/33483485
http://dx.doi.org/10.1038/s41537-020-00132-1
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