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The RNA-binding protein LARP1 is dispensable for pancreatic β-cell function and mass

Mechanistic target of rapamycin complex 1 (mTORC1) deficiency or chronic hyperactivation in pancreatic β-cells leads to diabetes. mTORC1 complexes with La-related protein 1 (LARP1) to specifically regulate the expression of 5′ terminal oligopyrimidine tract (5′TOP) mRNAs which encode proteins of the...

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Detalles Bibliográficos
Autores principales:	Werneck-de-Castro, Joao Pedro, Peçanha, Flavia Leticia Martins, Silvestre, Diego Henrique, Bernal-Mizrachi, Ernesto
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822907/ https://www.ncbi.nlm.nih.gov/pubmed/33483593 http://dx.doi.org/10.1038/s41598-021-81457-4

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