Enhanced BCR signaling inflicts early plasmablast and germinal center B cell death

It is still not clear how B cell receptor (BCR) signaling intensity affects plasma cell (PC) and germinal center (GC) B cell differentiation. We generated Cγ1(Cre/wt)Ptpn6(fl/fl) mice where SHP-1, a negative regulator of BCR signaling, is deleted rapidly after B cell activation. Although immunizatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Yam-Puc, Juan Carlos, Zhang, Lingling, Maqueda-Alfaro, Raul A, Garcia-Ibanez, Laura, Zhang, Yang, Davies, Jessica, Senis, Yotis A, Snaith, Michael, Toellner, Kai-Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7822941/
https://www.ncbi.nlm.nih.gov/pubmed/33532715
http://dx.doi.org/10.1016/j.isci.2021.102038

Ejemplares similares

Ejemplares similares