Cargando…

IDentif.AI: Rapidly optimizing combination therapy design against severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐Cov‐2) with digital drug development

The emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) led to multiple drug repurposing clinical trials that have yielded largely uncertain outcomes. To overcome this challenge, we used IDentif.AI, a platform that pairs experimental validation with artificial intelligence (AI)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Blasiak, Agata, Lim, Jhin Jieh, Seah, Shirley Gek Kheng, Kee, Theodore, Remus, Alexandria, Chye, De Hoe, Wong, Pui San, Hooi, Lissa, Truong, Anh T. L., Le, Nguyen, Chan, Conrad E. Z., Desai, Rishi, Ding, Xianting, Hanson, Brendon J., Chow, Edward Kai‐Hua, Ho, Dean
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2020
Materias:	Research Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823122/ https://www.ncbi.nlm.nih.gov/pubmed/33532594 http://dx.doi.org/10.1002/btm2.10196

Ejemplares similares

The IDentif.AI-x pandemic readiness platform: Rapid prioritization of optimized COVID-19 combination therapy regimens
por: Blasiak, Agata, et al.
Publicado: (2022)

Project IDentif.AI: Harnessing Artificial Intelligence to Rapidly Optimize Combination Therapy Development for Infectious Disease Intervention
por: Abdulla, Aynur, et al.
Publicado: (2020)

Addressing antimicrobial resistance with the IDentif.AI platform: Rapidly optimizing clinically actionable combination therapy regimens against nontuberculous mycobacteria
por: Mukherjee, Devika, et al.
Publicado: (2022)

Genetic characterisation of influenza C viruses detected in Singapore in 2006
por: Ting, Pei‐jun, et al.
Publicado: (2015)

Rational drug combination design in patient-derived avatars reveals effective inhibition of hepatocellular carcinoma with proteasome and CDK inhibitors
por: Lim, Jhin Jieh, et al.
Publicado: (2022)

A System Based-Approach to Examine Host Response during Infection with Influenza A Virus Subtype H7N9 in Human and Avian Cells
por: Taye, Biruhalem, et al.
Publicado: (2020)

The Cellular Characterization of SARS-CoV-2 Spike Protein in Virus-Infected Cells Using the Receptor Binding Domain Binding Specific Human Monoclonal Antibodies
por: Chan, Conrad En-Zuo, et al.
Publicado: (2022)

Characteristics of Mobile Health Platforms for Depression and Anxiety: Content Analysis Through a Systematic Review of the Literature and Systematic Search of Two App Stores
por: Leong, Qiao Ying, et al.
Publicado: (2022)

Physicians’ Perspectives on AI in Clinical Decision Support Systems: Interview Study of the CURATE.AI Personalized Dose Optimization Platform
por: Vijayakumar, Smrithi, et al.
Publicado: (2023)

Viral agents responsible for febrile respiratory illnesses among military recruits training in tropical Singapore
por: Seah, Shirley Gek-Kheng, et al.
Publicado: (2010)

Epigenetics in cancer stem cells
por: Toh, Tan Boon, et al.
Publicado: (2017)

Epigenetics of hepatocellular carcinoma
por: Toh, Tan Boon, et al.
Publicado: (2019)

Eph receptor B2 (EPHB2) regulates cancer stem cell-like properties in hepatocellular carcinoma
por: Lim, Jhin Jieh, et al.
Publicado: (2022)

Frequent upregulation of G9a promotes RelB-dependent proliferation and survival in multiple myeloma
por: Zhang, Xi Yun, et al.
Publicado: (2020)

CURATE.AI COR-Tx platform as a digital therapy and digital diagnostic for cognitive function in patients with brain tumour postradiotherapy treatment: protocol for a prospective mixed-methods feasibility clinical trial
por: Remus, Alexandria, et al.
Publicado: (2023)

Histone‐lysine N‐methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc‐driven liver cancer
por: Thng, Dexter Kai Hao, et al.
Publicado: (2023)

JAK/STAT signaling in hepatocellular carcinoma
por: Hin Tang, Justin Jit, et al.
Publicado: (2020)

The diagnostic targeting of a carbohydrate virulence factor from M.Tuberculosis
por: Chan, Conrad E., et al.
Publicado: (2015)

AI vs. AI: Can AI Detect AI-Generated Images?
por: Baraheem, Samah S., et al.
Publicado: (2023)

First-in-Human Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Rapidly Developed SARS-CoV-2 Therapeutic Antibody, AOD01, in Healthy Adults
por: Prativadibhayankaram, Venkateshan S., et al.
Publicado: (2022)

Methodology in core outcome set (COS) development: the impact of patient interviews and using a 5-point versus a 9-point Delphi rating scale on core outcome selection in a COS development study
por: Remus, Alexandria, et al.
Publicado: (2021)

Economic Evaluation Associated With Clinical-Grade Mobile App–Based Digital Therapeutic Interventions: Systematic Review
por: Sapanel, Yoann, et al.
Publicado: (2023)

Optics for AI and AI for optics
por: Wei, Jinlong, et al.
Publicado: (2020)

Predicting and Validating 30-day Hospital Readmission in Adults With Diabetes Whose Index Admission Is Diabetes-related
por: Soh, Jade Gek Sang, et al.
Publicado: (2022)

Traumatic abdominal wall hernia after impact from handlebar: A case report
por: Chan, Kheng Hooi, et al.
Publicado: (2021)

Explainability agreement between dermatologists and five visual explanations techniques in deep neural networks for melanoma AI classification
por: Giavina-Bianchi, Mara, et al.
Publicado: (2023)

Predictors of 30-day unplanned hospital readmission among adult patients with diabetes mellitus: a systematic review with meta-analysis
por: Soh, Jade Gek Sang, et al.
Publicado: (2020)

Harnessing the Potential of AI for Indico.AI
por: Vohra, Vasant
Publicado: (2023)

AI-clinician collaboration via disagreement prediction: A decision pipeline and retrospective analysis of real-world radiologist-AI interactions
por: Sanchez, Morgan, et al.
Publicado: (2023)

Retrospective analysis and prospective validation of an AI-based software for intracranial haemorrhage detection at a high-volume trauma centre
por: Zia, Adil, et al.
Publicado: (2022)

Challenges and Opportunities in Deploying COVID-19 Cough AI Systems
por: Khanzada, Amil, et al.
Publicado: (2021)

Shaping the Future of Older Adult Care: ChatGPT, Advanced AI, and the Transformation of Clinical Practice
por: Fear, Kathleen, et al.
Publicado: (2023)

Promoting Research, Awareness, and Discussion on AI in Medicine Using #MedTwitterAI: A Longitudinal Twitter Hashtag Analysis
por: Nawaz, Faisal A., et al.
Publicado: (2022)

The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody
por: Chan, Conrad E. Z., et al.
Publicado: (2021)

Emerging challenges in AI and the need for AI ethics education
por: Borenstein, Jason, et al.
Publicado: (2020)

Direct Human-AI Comparison in the Animal-AI Environment
por: Voudouris, Konstantinos, et al.
Publicado: (2022)

AI pitfalls and what not to do: mitigating bias in AI
por: Gichoya, Judy Wawira, et al.
Publicado: (2023)

News Sentiment Informed Time-series Analyzing AI (SITALA) to curb the spread of COVID-19 in Houston
por: Desai, Prathamesh S.
Publicado: (2021)

Bivalent binding of a fully human IgG to the SARS-CoV-2 spike proteins reveals mechanisms of potent neutralization
por: Wang, Bei, et al.
Publicado: (2020)

Two linear epitopes on the SARS-CoV-2 spike protein that elicit neutralising antibodies in COVID-19 patients
por: Poh, Chek Meng, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9ce2448durd1kladlovij9s9as