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Training Feedforward Neural Network Using Enhanced Black Hole Algorithm: A Case Study on COVID-19 Related ACE2 Gene Expression Classification

The aim of this paper is twofold. First, black hole algorithm (BHA) is proposed as a new training algorithm for feedforward neural networks (FNNs), since most traditional and metaheuristic algorithms for training FNNs suffer from the problem of slow coverage and getting stuck at local optima. BHA pr...

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Autores principales: Pashaei, Elham, Pashaei, Elnaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823180/
https://www.ncbi.nlm.nih.gov/pubmed/33520590
http://dx.doi.org/10.1007/s13369-020-05217-8
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author Pashaei, Elham
Pashaei, Elnaz
author_facet Pashaei, Elham
Pashaei, Elnaz
author_sort Pashaei, Elham
collection PubMed
description The aim of this paper is twofold. First, black hole algorithm (BHA) is proposed as a new training algorithm for feedforward neural networks (FNNs), since most traditional and metaheuristic algorithms for training FNNs suffer from the problem of slow coverage and getting stuck at local optima. BHA provides a reliable alternative to address these drawbacks. Second, complementary learning components and Levy flight random walk are introduced into BHA to result in a novel optimization algorithm (BHACRW) for the purpose of improving the FNNs’ accuracy by finding optimal weights and biases. Four benchmark functions are first used to evaluate BHACRW’s performance in numerical optimization problems. Later, the classification performance of the suggested models, using BHA and BHACRW for training FNN, is evaluated against seven various benchmark datasets: iris, wine, blood, liver disorders, seeds, Statlog (Heart), balance scale. Experimental result demonstrates that the BHACRW performs better in terms of mean square error (MSE) and accuracy of training FNN, compared to standard BHA and eight well-known metaheuristic algorithms: whale optimization algorithm (WOA), biogeography-based optimizer (BBO), gravitational search algorithm (GSA), genetic algorithm (GA), cuckoo search (CS), multiverse optimizer (MVO), symbiotic organisms search (SOS), and particle swarm optimization (PSO). Moreover, we examined the classification performance of the suggested approach on the angiotensin-converting enzyme 2 (ACE2) gene expression as a coronavirus receptor, which has been overexpressed in human rhinovirus-infected nasal tissue. Results demonstrate that BHACRW-FNN achieves the highest accuracy on the dataset compared to other classifiers.
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spelling pubmed-78231802021-01-25 Training Feedforward Neural Network Using Enhanced Black Hole Algorithm: A Case Study on COVID-19 Related ACE2 Gene Expression Classification Pashaei, Elham Pashaei, Elnaz Arab J Sci Eng Research Article-Computer Engineering and Computer Science The aim of this paper is twofold. First, black hole algorithm (BHA) is proposed as a new training algorithm for feedforward neural networks (FNNs), since most traditional and metaheuristic algorithms for training FNNs suffer from the problem of slow coverage and getting stuck at local optima. BHA provides a reliable alternative to address these drawbacks. Second, complementary learning components and Levy flight random walk are introduced into BHA to result in a novel optimization algorithm (BHACRW) for the purpose of improving the FNNs’ accuracy by finding optimal weights and biases. Four benchmark functions are first used to evaluate BHACRW’s performance in numerical optimization problems. Later, the classification performance of the suggested models, using BHA and BHACRW for training FNN, is evaluated against seven various benchmark datasets: iris, wine, blood, liver disorders, seeds, Statlog (Heart), balance scale. Experimental result demonstrates that the BHACRW performs better in terms of mean square error (MSE) and accuracy of training FNN, compared to standard BHA and eight well-known metaheuristic algorithms: whale optimization algorithm (WOA), biogeography-based optimizer (BBO), gravitational search algorithm (GSA), genetic algorithm (GA), cuckoo search (CS), multiverse optimizer (MVO), symbiotic organisms search (SOS), and particle swarm optimization (PSO). Moreover, we examined the classification performance of the suggested approach on the angiotensin-converting enzyme 2 (ACE2) gene expression as a coronavirus receptor, which has been overexpressed in human rhinovirus-infected nasal tissue. Results demonstrate that BHACRW-FNN achieves the highest accuracy on the dataset compared to other classifiers. Springer Berlin Heidelberg 2021-01-23 2021 /pmc/articles/PMC7823180/ /pubmed/33520590 http://dx.doi.org/10.1007/s13369-020-05217-8 Text en © King Fahd University of Petroleum & Minerals 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Article-Computer Engineering and Computer Science
Pashaei, Elham
Pashaei, Elnaz
Training Feedforward Neural Network Using Enhanced Black Hole Algorithm: A Case Study on COVID-19 Related ACE2 Gene Expression Classification
title Training Feedforward Neural Network Using Enhanced Black Hole Algorithm: A Case Study on COVID-19 Related ACE2 Gene Expression Classification
title_full Training Feedforward Neural Network Using Enhanced Black Hole Algorithm: A Case Study on COVID-19 Related ACE2 Gene Expression Classification
title_fullStr Training Feedforward Neural Network Using Enhanced Black Hole Algorithm: A Case Study on COVID-19 Related ACE2 Gene Expression Classification
title_full_unstemmed Training Feedforward Neural Network Using Enhanced Black Hole Algorithm: A Case Study on COVID-19 Related ACE2 Gene Expression Classification
title_short Training Feedforward Neural Network Using Enhanced Black Hole Algorithm: A Case Study on COVID-19 Related ACE2 Gene Expression Classification
title_sort training feedforward neural network using enhanced black hole algorithm: a case study on covid-19 related ace2 gene expression classification
topic Research Article-Computer Engineering and Computer Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823180/
https://www.ncbi.nlm.nih.gov/pubmed/33520590
http://dx.doi.org/10.1007/s13369-020-05217-8
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