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Neuroprotective function of microglia in the developing brain
Microglia are the resident immune cells of the central nervous system and are important for immune processes. Besides their classical roles in pathological conditions, these cells also dynamically interact with neurons and influence their structure and function in physiological conditions. Recent ev...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Portland Press Ltd.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823182/ https://www.ncbi.nlm.nih.gov/pubmed/33532089 http://dx.doi.org/10.1042/NS20200024 |
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author | Fujita, Yuki Yamashita, Toshihide |
author_facet | Fujita, Yuki Yamashita, Toshihide |
author_sort | Fujita, Yuki |
collection | PubMed |
description | Microglia are the resident immune cells of the central nervous system and are important for immune processes. Besides their classical roles in pathological conditions, these cells also dynamically interact with neurons and influence their structure and function in physiological conditions. Recent evidence revealed their role in healthy brain homeostasis, including the regulation of neurogenesis, cell survival, and synapse maturation and elimination, especially in the developing brain. In this review, we summarize the current state of knowledge on microglia in brain development, with a focus on their neuroprotective function. We will also discuss how microglial dysfunction may lead to the impairment of brain function, thereby contributing to disease development. |
format | Online Article Text |
id | pubmed-7823182 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Portland Press Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-78231822021-02-01 Neuroprotective function of microglia in the developing brain Fujita, Yuki Yamashita, Toshihide Neuronal Signal Neuroscience Microglia are the resident immune cells of the central nervous system and are important for immune processes. Besides their classical roles in pathological conditions, these cells also dynamically interact with neurons and influence their structure and function in physiological conditions. Recent evidence revealed their role in healthy brain homeostasis, including the regulation of neurogenesis, cell survival, and synapse maturation and elimination, especially in the developing brain. In this review, we summarize the current state of knowledge on microglia in brain development, with a focus on their neuroprotective function. We will also discuss how microglial dysfunction may lead to the impairment of brain function, thereby contributing to disease development. Portland Press Ltd. 2021-01-22 /pmc/articles/PMC7823182/ /pubmed/33532089 http://dx.doi.org/10.1042/NS20200024 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the . |
spellingShingle | Neuroscience Fujita, Yuki Yamashita, Toshihide Neuroprotective function of microglia in the developing brain |
title | Neuroprotective function of microglia in the developing brain |
title_full | Neuroprotective function of microglia in the developing brain |
title_fullStr | Neuroprotective function of microglia in the developing brain |
title_full_unstemmed | Neuroprotective function of microglia in the developing brain |
title_short | Neuroprotective function of microglia in the developing brain |
title_sort | neuroprotective function of microglia in the developing brain |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823182/ https://www.ncbi.nlm.nih.gov/pubmed/33532089 http://dx.doi.org/10.1042/NS20200024 |
work_keys_str_mv | AT fujitayuki neuroprotectivefunctionofmicrogliainthedevelopingbrain AT yamashitatoshihide neuroprotectivefunctionofmicrogliainthedevelopingbrain |