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Research progress of ghrelin on cardiovascular disease

Ghrelin, a 28-aminoacid peptide, was isolated from the human and rat stomach and identified in 1999 as an endogenous ligand for the growth hormone secretagogue-receptor (GHS-R). In addition to stimulating appetite and regulating energy balance, ghrelin and its receptor GHS-R1a have a direct effect o...

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Detalles Bibliográficos
Autores principales: Yuan, Ming-Jie, Li, Wei, Zhong, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823193/
https://www.ncbi.nlm.nih.gov/pubmed/33427286
http://dx.doi.org/10.1042/BSR20203387
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author Yuan, Ming-Jie
Li, Wei
Zhong, Peng
author_facet Yuan, Ming-Jie
Li, Wei
Zhong, Peng
author_sort Yuan, Ming-Jie
collection PubMed
description Ghrelin, a 28-aminoacid peptide, was isolated from the human and rat stomach and identified in 1999 as an endogenous ligand for the growth hormone secretagogue-receptor (GHS-R). In addition to stimulating appetite and regulating energy balance, ghrelin and its receptor GHS-R1a have a direct effect on the cardiovascular system. In recent years, it has been shown that ghrelin exerts cardioprotective effects, including the modulation of sympathetic activity and hypertension, enhancement of the vascular activity and angiogenesis, inhibition of arrhythmias, reduction in heart failure and inhibition of cardiac remodeling after myocardial infarction (MI). The cardiovascular protective effect of ghrelin may be associated with anti-inflammation, anti-apoptosis, inhibited sympathetic nerve activation, regulated autophagy, and endothelial dysfunction. However, the molecular mechanisms underlying the effects of ghrelin on the cardiovascular system have not been fully elucidated, and no specific therapeutic agent has been established. It is important to further explore the pharmacological potential of ghrelin pathway modulation for the treatment of cardiovascular diseases.
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spelling pubmed-78231932021-02-04 Research progress of ghrelin on cardiovascular disease Yuan, Ming-Jie Li, Wei Zhong, Peng Biosci Rep Cardiovascular System & Vascular Biology Ghrelin, a 28-aminoacid peptide, was isolated from the human and rat stomach and identified in 1999 as an endogenous ligand for the growth hormone secretagogue-receptor (GHS-R). In addition to stimulating appetite and regulating energy balance, ghrelin and its receptor GHS-R1a have a direct effect on the cardiovascular system. In recent years, it has been shown that ghrelin exerts cardioprotective effects, including the modulation of sympathetic activity and hypertension, enhancement of the vascular activity and angiogenesis, inhibition of arrhythmias, reduction in heart failure and inhibition of cardiac remodeling after myocardial infarction (MI). The cardiovascular protective effect of ghrelin may be associated with anti-inflammation, anti-apoptosis, inhibited sympathetic nerve activation, regulated autophagy, and endothelial dysfunction. However, the molecular mechanisms underlying the effects of ghrelin on the cardiovascular system have not been fully elucidated, and no specific therapeutic agent has been established. It is important to further explore the pharmacological potential of ghrelin pathway modulation for the treatment of cardiovascular diseases. Portland Press Ltd. 2021-01-22 /pmc/articles/PMC7823193/ /pubmed/33427286 http://dx.doi.org/10.1042/BSR20203387 Text en © 2021 The Author(s). https://creativecommons.org/licenses/by/4.0/ This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Cardiovascular System & Vascular Biology
Yuan, Ming-Jie
Li, Wei
Zhong, Peng
Research progress of ghrelin on cardiovascular disease
title Research progress of ghrelin on cardiovascular disease
title_full Research progress of ghrelin on cardiovascular disease
title_fullStr Research progress of ghrelin on cardiovascular disease
title_full_unstemmed Research progress of ghrelin on cardiovascular disease
title_short Research progress of ghrelin on cardiovascular disease
title_sort research progress of ghrelin on cardiovascular disease
topic Cardiovascular System & Vascular Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823193/
https://www.ncbi.nlm.nih.gov/pubmed/33427286
http://dx.doi.org/10.1042/BSR20203387
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