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An Acinetobacter non-baumannii Population Study: Antimicrobial Resistance Genes (ARGs)

Acinetobacter non-baumannii species are becoming common etiologic agents of nosocomial infections. Furthermore, clinical isolates belonging to this group of bacteria are usually resistant to one or more antibiotics. The current information about antibiotic resistance genes in the different A. non-ba...

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Autores principales: Baraka, Adam, Traglia, German M., Montaña, Sabrina, Tolmasky, Marcelo E., Ramirez, Maria Soledad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823295/
https://www.ncbi.nlm.nih.gov/pubmed/33375352
http://dx.doi.org/10.3390/antibiotics10010016
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author Baraka, Adam
Traglia, German M.
Montaña, Sabrina
Tolmasky, Marcelo E.
Ramirez, Maria Soledad
author_facet Baraka, Adam
Traglia, German M.
Montaña, Sabrina
Tolmasky, Marcelo E.
Ramirez, Maria Soledad
author_sort Baraka, Adam
collection PubMed
description Acinetobacter non-baumannii species are becoming common etiologic agents of nosocomial infections. Furthermore, clinical isolates belonging to this group of bacteria are usually resistant to one or more antibiotics. The current information about antibiotic resistance genes in the different A. non-baumannii species has not yet been studied as a whole. Therefore, we did a comparative study of the resistomes of A. non-baumannii pathogens based on information available in published articles and genome sequences. We searched the available literature and sequences deposited in GenBank to identify the resistance gene content of A. calcoaceticus, A. lwoffii, A. junii, A. soli, A. ursingii, A. bereziniae, A. nosocomialis, A. portensis, A. guerrae, A. baylyi, A. calcoaceticus, A. disperses, A. johnsonii, A. junii, A. lwoffii, A. nosocomialis, A. oleivorans, A. oryzae, A. pittii, A. radioresistens, and A. venetianus. The most common genes were those coding for different β-lactamases, including the carbapenemase genes bla(NDM-1) and bla(OXA-58). A. pittii was the species with the most β-lactamase resistance genes reported. Other genes that were commonly found include those encoding some aminoglycoside modifying enzymes, the most common being aph(6)-Id, ant(3″)-IIa, and aph(3″)-Ib, and efflux pumps. All or part of the genes coding for the AdeABC, AdeFGH, and AdeIJK efflux pumps were the most commonly found. This article incorporates all the current information about A. non-baumannii resistance genes. The comparison of the different resistomes shows that there are similarities in the genes present, but there are also significant differences that could impact the efficiency of treatments depending on the etiologic agent. This article is a comprehensive resource about A. non-baumannii resistomes.
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spelling pubmed-78232952021-01-24 An Acinetobacter non-baumannii Population Study: Antimicrobial Resistance Genes (ARGs) Baraka, Adam Traglia, German M. Montaña, Sabrina Tolmasky, Marcelo E. Ramirez, Maria Soledad Antibiotics (Basel) Communication Acinetobacter non-baumannii species are becoming common etiologic agents of nosocomial infections. Furthermore, clinical isolates belonging to this group of bacteria are usually resistant to one or more antibiotics. The current information about antibiotic resistance genes in the different A. non-baumannii species has not yet been studied as a whole. Therefore, we did a comparative study of the resistomes of A. non-baumannii pathogens based on information available in published articles and genome sequences. We searched the available literature and sequences deposited in GenBank to identify the resistance gene content of A. calcoaceticus, A. lwoffii, A. junii, A. soli, A. ursingii, A. bereziniae, A. nosocomialis, A. portensis, A. guerrae, A. baylyi, A. calcoaceticus, A. disperses, A. johnsonii, A. junii, A. lwoffii, A. nosocomialis, A. oleivorans, A. oryzae, A. pittii, A. radioresistens, and A. venetianus. The most common genes were those coding for different β-lactamases, including the carbapenemase genes bla(NDM-1) and bla(OXA-58). A. pittii was the species with the most β-lactamase resistance genes reported. Other genes that were commonly found include those encoding some aminoglycoside modifying enzymes, the most common being aph(6)-Id, ant(3″)-IIa, and aph(3″)-Ib, and efflux pumps. All or part of the genes coding for the AdeABC, AdeFGH, and AdeIJK efflux pumps were the most commonly found. This article incorporates all the current information about A. non-baumannii resistance genes. The comparison of the different resistomes shows that there are similarities in the genes present, but there are also significant differences that could impact the efficiency of treatments depending on the etiologic agent. This article is a comprehensive resource about A. non-baumannii resistomes. MDPI 2020-12-26 /pmc/articles/PMC7823295/ /pubmed/33375352 http://dx.doi.org/10.3390/antibiotics10010016 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Baraka, Adam
Traglia, German M.
Montaña, Sabrina
Tolmasky, Marcelo E.
Ramirez, Maria Soledad
An Acinetobacter non-baumannii Population Study: Antimicrobial Resistance Genes (ARGs)
title An Acinetobacter non-baumannii Population Study: Antimicrobial Resistance Genes (ARGs)
title_full An Acinetobacter non-baumannii Population Study: Antimicrobial Resistance Genes (ARGs)
title_fullStr An Acinetobacter non-baumannii Population Study: Antimicrobial Resistance Genes (ARGs)
title_full_unstemmed An Acinetobacter non-baumannii Population Study: Antimicrobial Resistance Genes (ARGs)
title_short An Acinetobacter non-baumannii Population Study: Antimicrobial Resistance Genes (ARGs)
title_sort acinetobacter non-baumannii population study: antimicrobial resistance genes (args)
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823295/
https://www.ncbi.nlm.nih.gov/pubmed/33375352
http://dx.doi.org/10.3390/antibiotics10010016
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