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Progress of Cancer Nanotechnology as Diagnostics, Therapeutics, and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges

Early detection, right therapeutic intervention, and simultaneous effectiveness mapping are considered the critical factors in successful cancer therapy. Nevertheless, these factors experience the limitations of conventional cancer diagnostics and therapeutics delivery approaches. Along with providi...

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Autores principales: Alshehri, Sultan, Imam, Syed Sarim, Rizwanullah, Md., Akhter, Sohail, Mahdi, Wael, Kazi, Mohsin, Ahmad, Javed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823416/
https://www.ncbi.nlm.nih.gov/pubmed/33374391
http://dx.doi.org/10.3390/pharmaceutics13010024
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author Alshehri, Sultan
Imam, Syed Sarim
Rizwanullah, Md.
Akhter, Sohail
Mahdi, Wael
Kazi, Mohsin
Ahmad, Javed
author_facet Alshehri, Sultan
Imam, Syed Sarim
Rizwanullah, Md.
Akhter, Sohail
Mahdi, Wael
Kazi, Mohsin
Ahmad, Javed
author_sort Alshehri, Sultan
collection PubMed
description Early detection, right therapeutic intervention, and simultaneous effectiveness mapping are considered the critical factors in successful cancer therapy. Nevertheless, these factors experience the limitations of conventional cancer diagnostics and therapeutics delivery approaches. Along with providing the targeted therapeutics delivery, advances in nanomedicines have allowed the combination of therapy and diagnostics in a single system (called cancer theranostics). This paper discusses the progress in the pre-clinical and clinical development of therapeutics, diagnostics, and theranostics cancer nanomedicines. It has been well evident that compared to the overabundance of works that claimed success in pre-clinical studies, merely 15 and around 75 cancer nanomedicines are approved, and currently under clinical trials, respectively. Thus, we also brief the critical bottlenecks in the successful clinical translation of cancer nanomedicines.
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spelling pubmed-78234162021-01-24 Progress of Cancer Nanotechnology as Diagnostics, Therapeutics, and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges Alshehri, Sultan Imam, Syed Sarim Rizwanullah, Md. Akhter, Sohail Mahdi, Wael Kazi, Mohsin Ahmad, Javed Pharmaceutics Review Early detection, right therapeutic intervention, and simultaneous effectiveness mapping are considered the critical factors in successful cancer therapy. Nevertheless, these factors experience the limitations of conventional cancer diagnostics and therapeutics delivery approaches. Along with providing the targeted therapeutics delivery, advances in nanomedicines have allowed the combination of therapy and diagnostics in a single system (called cancer theranostics). This paper discusses the progress in the pre-clinical and clinical development of therapeutics, diagnostics, and theranostics cancer nanomedicines. It has been well evident that compared to the overabundance of works that claimed success in pre-clinical studies, merely 15 and around 75 cancer nanomedicines are approved, and currently under clinical trials, respectively. Thus, we also brief the critical bottlenecks in the successful clinical translation of cancer nanomedicines. MDPI 2020-12-24 /pmc/articles/PMC7823416/ /pubmed/33374391 http://dx.doi.org/10.3390/pharmaceutics13010024 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Alshehri, Sultan
Imam, Syed Sarim
Rizwanullah, Md.
Akhter, Sohail
Mahdi, Wael
Kazi, Mohsin
Ahmad, Javed
Progress of Cancer Nanotechnology as Diagnostics, Therapeutics, and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges
title Progress of Cancer Nanotechnology as Diagnostics, Therapeutics, and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges
title_full Progress of Cancer Nanotechnology as Diagnostics, Therapeutics, and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges
title_fullStr Progress of Cancer Nanotechnology as Diagnostics, Therapeutics, and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges
title_full_unstemmed Progress of Cancer Nanotechnology as Diagnostics, Therapeutics, and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges
title_short Progress of Cancer Nanotechnology as Diagnostics, Therapeutics, and Theranostics Nanomedicine: Preclinical Promise and Translational Challenges
title_sort progress of cancer nanotechnology as diagnostics, therapeutics, and theranostics nanomedicine: preclinical promise and translational challenges
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823416/
https://www.ncbi.nlm.nih.gov/pubmed/33374391
http://dx.doi.org/10.3390/pharmaceutics13010024
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