Cargando…
Longer Exposure to Left-to-Right Shunts Is a Risk Factor for Pulmonary Vein Stenosis in Patients with Trisomy 21
We conducted a study to determine whether patients born with Trisomy 21 and left-to-right shunts who develop pulmonary vein stenosis (PVS) have a longer exposure to shunt physiology compared to those who do not develop PVS. We included patients seen at Boston Children’s Hospital between 15 August 20...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823486/ https://www.ncbi.nlm.nih.gov/pubmed/33401418 http://dx.doi.org/10.3390/children8010019 |
_version_ | 1783639846996148224 |
---|---|
author | Choi, Connie Gauvreau, Kimberlee Levy, Philip Callahan, Ryan Jenkins, Kathy J. Chen, Minghui |
author_facet | Choi, Connie Gauvreau, Kimberlee Levy, Philip Callahan, Ryan Jenkins, Kathy J. Chen, Minghui |
author_sort | Choi, Connie |
collection | PubMed |
description | We conducted a study to determine whether patients born with Trisomy 21 and left-to-right shunts who develop pulmonary vein stenosis (PVS) have a longer exposure to shunt physiology compared to those who do not develop PVS. We included patients seen at Boston Children’s Hospital between 15 August 2006 and 31 August 2017 born with Trisomy 21 and left-to-right shunts who developed PVS within 24 months of age. We conducted a retrospective 3:1 matched case–control study. The primary predictor was length of exposure to shunt as defined as date of birth to the first echocardiogram showing mild or no shunt. Case patients with PVS were more likely to have a longer exposure to shunt than patients in the control group (6 vs. 3 months, p-value 0.002). Additionally, PVS patients were also more likely to have their initial repair ≥ 4 months of age (81% vs. 42%, p-value 0.003) and have a gestational age ≤ 35 weeks (48% vs. 13%, p-value 0.003). Time exposed to shunts may be an important modifiable risk factor for PVS in patients with Trisomy 21. |
format | Online Article Text |
id | pubmed-7823486 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78234862021-01-24 Longer Exposure to Left-to-Right Shunts Is a Risk Factor for Pulmonary Vein Stenosis in Patients with Trisomy 21 Choi, Connie Gauvreau, Kimberlee Levy, Philip Callahan, Ryan Jenkins, Kathy J. Chen, Minghui Children (Basel) Article We conducted a study to determine whether patients born with Trisomy 21 and left-to-right shunts who develop pulmonary vein stenosis (PVS) have a longer exposure to shunt physiology compared to those who do not develop PVS. We included patients seen at Boston Children’s Hospital between 15 August 2006 and 31 August 2017 born with Trisomy 21 and left-to-right shunts who developed PVS within 24 months of age. We conducted a retrospective 3:1 matched case–control study. The primary predictor was length of exposure to shunt as defined as date of birth to the first echocardiogram showing mild or no shunt. Case patients with PVS were more likely to have a longer exposure to shunt than patients in the control group (6 vs. 3 months, p-value 0.002). Additionally, PVS patients were also more likely to have their initial repair ≥ 4 months of age (81% vs. 42%, p-value 0.003) and have a gestational age ≤ 35 weeks (48% vs. 13%, p-value 0.003). Time exposed to shunts may be an important modifiable risk factor for PVS in patients with Trisomy 21. MDPI 2021-01-01 /pmc/articles/PMC7823486/ /pubmed/33401418 http://dx.doi.org/10.3390/children8010019 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Choi, Connie Gauvreau, Kimberlee Levy, Philip Callahan, Ryan Jenkins, Kathy J. Chen, Minghui Longer Exposure to Left-to-Right Shunts Is a Risk Factor for Pulmonary Vein Stenosis in Patients with Trisomy 21 |
title | Longer Exposure to Left-to-Right Shunts Is a Risk Factor for Pulmonary Vein Stenosis in Patients with Trisomy 21 |
title_full | Longer Exposure to Left-to-Right Shunts Is a Risk Factor for Pulmonary Vein Stenosis in Patients with Trisomy 21 |
title_fullStr | Longer Exposure to Left-to-Right Shunts Is a Risk Factor for Pulmonary Vein Stenosis in Patients with Trisomy 21 |
title_full_unstemmed | Longer Exposure to Left-to-Right Shunts Is a Risk Factor for Pulmonary Vein Stenosis in Patients with Trisomy 21 |
title_short | Longer Exposure to Left-to-Right Shunts Is a Risk Factor for Pulmonary Vein Stenosis in Patients with Trisomy 21 |
title_sort | longer exposure to left-to-right shunts is a risk factor for pulmonary vein stenosis in patients with trisomy 21 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823486/ https://www.ncbi.nlm.nih.gov/pubmed/33401418 http://dx.doi.org/10.3390/children8010019 |
work_keys_str_mv | AT choiconnie longerexposuretolefttorightshuntsisariskfactorforpulmonaryveinstenosisinpatientswithtrisomy21 AT gauvreaukimberlee longerexposuretolefttorightshuntsisariskfactorforpulmonaryveinstenosisinpatientswithtrisomy21 AT levyphilip longerexposuretolefttorightshuntsisariskfactorforpulmonaryveinstenosisinpatientswithtrisomy21 AT callahanryan longerexposuretolefttorightshuntsisariskfactorforpulmonaryveinstenosisinpatientswithtrisomy21 AT jenkinskathyj longerexposuretolefttorightshuntsisariskfactorforpulmonaryveinstenosisinpatientswithtrisomy21 AT chenminghui longerexposuretolefttorightshuntsisariskfactorforpulmonaryveinstenosisinpatientswithtrisomy21 |