Cargando…

Biological Regulatory Network (BRN) Analysis and Molecular Docking Simulations to Probe the Modulation of IP(3)R Mediated Ca(2+) Signaling in Cancer

Inositol trisphosphate receptor (IP(3)R) mediated Ca(+2) signaling is essential in determining the cell fate by regulating numerous cellular processes, including cell division and cell death. Despite extensive studies about the characterization of IP(3)R in cancer, the underlying molecular mechanism...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ismatullah, Humaira, Jabeen, Ishrat, Saeed, Muhammad Tariq
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823498/ https://www.ncbi.nlm.nih.gov/pubmed/33383780 http://dx.doi.org/10.3390/genes12010034

Ejemplares similares

Combined Pharmacophore and Grid-Independent Molecular Descriptors (GRIND) Analysis to Probe 3D Features of Inositol 1,4,5-Trisphosphate Receptor (IP(3)R) Inhibitors in Cancer
por: Ismatullah, Humaira, et al.
Publicado: (2021)

HuR interacts with lincBRN1a and lincBRN1b during neuronal stem cells differentiation
por: Carelli, Stephana, et al.
Publicado: (2019)

Molecular Dynamic Simulations to Probe Stereoselectivity of Tiagabine Binding with Human GAT1
por: Zafar, Sadia, et al.
Publicado: (2020)

Molecular Docking Guided Grid-Independent Descriptor Analysis to Probe the Impact of Water Molecules on Conformational Changes of hERG Inhibitors in Drug Trapping Phenomenon
por: Munawar, Saba, et al.
Publicado: (2019)

Research progress of the transcription factor Brn4
por: Wu, Yuying, et al.
Publicado: (2021)

nGnG Amacrine Cells and Brn3b-negative M1 ipRGCs are Specifically Labeled in the ChAT-ChR2-EYFP Mouse
por: Cui, Ling-Jie, et al.
Publicado: (2020)

BRN2 expression increases anoikis resistance in melanoma
por: Pierce, Carly J., et al.
Publicado: (2020)

Molecular Dynamics Simulation Framework to Probe the Binding Hypothesis of CYP3A4 Inhibitors
por: Kiani, Yusra Sajid, et al.
Publicado: (2019)

Antibacterial Potential of Novel Acetamide Derivatives of 2-Mercaptobenzothiazole: Synthesis and Docking Studies
por: Sheikh, Ahmed Sadiq, et al.
Publicado: (2023)

BRN2 is a non-canonical melanoma tumor-suppressor
por: Hamm, Michael, et al.
Publicado: (2021)

Decoding the Role of Epigenetics in Breast Cancer Using Formal Modeling and Machine-Learning Methods
por: Asim, Ayesha, et al.
Publicado: (2022)

MITF and BRN2 contribute to metastatic growth after dissemination of melanoma
por: Simmons, Jacinta L., et al.
Publicado: (2017)

HDAC2 Is Involved in the Regulation of BRN3A in Melanocytes and Melanoma
por: Heppt, Markus V., et al.
Publicado: (2022)

GRID-independent molecular descriptor analysis and molecular docking studies to mimic the binding hypothesis of γ-aminobutyric acid transporter 1 (GAT1) inhibitors
por: Zafar, Sadia, et al.
Publicado: (2019)

Essential but partially redundant roles for POU4F1/Brn-3a and POU4F2/Brn-3b transcription factors in the developing heart
por: Maskell, Lauren J, et al.
Publicado: (2017)

Synthesis, single crystal analysis, biological and docking evaluation of tetrazole derivatives
por: Aziz, Hamid, et al.
Publicado: (2018)

Protein Fragmentation As a Regulatory Mechanism: Insights from Two Different Ca(2+) Channels, RyR1 and IP(3)R
por: Neyroud, Daria
Publicado: (2017)

In silico transcriptional regulation and functional analysis of dengue shock syndrome associated SNPs in PLCE1 and MICB genes
por: Taqi, Malik Mumtaz, et al.
Publicado: (2016)

Termination of Ca(2+) Release for Clustered IP(3)R Channels
por: Rüdiger, Sten, et al.
Publicado: (2012)

A Novel Reporter Mouse Uncovers Endogenous Brn3b Expression
por: Miltner, Adam M., et al.
Publicado: (2019)

BRN2 as a key gene drives the early primate telencephalon development
por: Zhu, Xiaoqing, et al.
Publicado: (2022)

Clustering of IP(3) receptors by IP(3) retunes their regulation by IP(3) and Ca(2+)
por: Taufiq-Ur-Rahman,, et al.
Publicado: (2009)

IP(3)R at ER-Mitochondrial Contact Sites: Beyond the IP(3)R-GRP75-VDAC1 Ca(2+) Funnel
por: Atakpa-Adaji, Peace, et al.
Publicado: (2023)

Combined Machine Learning and GRID-Independent Molecular Descriptor (GRIND) Models to Probe the Activity Profiles of 5-Lipoxygenase Activating Protein Inhibitors
por: Khan, Hafiza Aliza, et al.
Publicado: (2022)

Rb induces a proliferative arrest and curtails Brn-2 expression in retinoblastoma cells
por: Cobrinik, David, et al.
Publicado: (2006)

Transcription factors Brn-3α and TRIM16 in cancers, association with hormone reception
por: Spirina, Liudmila V., et al.
Publicado: (2019)

Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival
por: Wiggins, Amanda K., et al.
Publicado: (2004)

Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesis
por: Braunstein, Evan M, et al.
Publicado: (2009)

Genetic Interactions between Brn3 Transcription Factors in Retinal Ganglion Cell Type Specification
por: Shi, Melody, et al.
Publicado: (2013)

An Intelligent Healthcare System Using IoT in Wireless Sensor Network
por: Jabeen, Tallat, et al.
Publicado: (2023)

TESLA Linac-IP Simulations
por: White, Glen, et al.
Publicado: (2004)

Formation of morpholine-acetamide derivatives as potent anti-tumor drug candidates: Pharmacological evaluation and molecular docking studies
por: Sheikh, Ahmed Sadiq, et al.
Publicado: (2023)

Changes in Ca(2+) Removal Can Mask the Effects of Geometry During IP(3)R Mediated Ca(2+) Signals
por: Piegari, Estefanía, et al.
Publicado: (2019)

Cdk5 regulates IP3R1-mediated Ca(2+) dynamics and Ca(2+)-mediated cell proliferation
por: NavaneethaKrishnan, Saranya, et al.
Publicado: (2022)

IP(3)Rs puff along: A SNAPpy dance with IP(3) and Ca(2+)
por: Nakhe, Arya Y., et al.
Publicado: (2023)

Impact of Gender in Renal Cell Carcinoma: The Relationship of FABP7 and BRN2 Expression with Overall Survival
por: Tan, Cheng, et al.
Publicado: (2014)

Phosphorylation of Tet3 by cdk5 is critical for robust activation of BRN2 during neuronal differentiation
por: Rao, Vinay Kumar, et al.
Publicado: (2020)

BrnQ-Type Branched-Chain Amino Acid Transporters Influence Bacillus anthracis Growth and Virulence
por: Dutta, Soumita, et al.
Publicado: (2022)

Brn3b regulates the formation of fear-related midbrain circuits and defensive responses to visual threat
por: Lee, Hyoseo, et al.
Publicado: (2023)

Rhodanine-3-acetamide derivatives as aldose and aldehyde reductase inhibitors to treat diabetic complications: synthesis, biological evaluation, molecular docking and simulation studies
por: Bacha, Mohsinul Mulk, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_1dnu707tfr3vmh3ogomeq5f491