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Serum Biomarkers for the Diagnosis of Glaucoma

Despite the importance of the early detection of glaucoma, most patients with progressive glaucoma show minimal symptoms. We aimed to evaluate biomarkers for glaucoma diagnosis in Korea. Forty-two volunteers with/without open-angle glaucoma were enrolled from January through October 2015—divided int...

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Autores principales: Shin, Young Joo, Kim, Eunbi, Han, Bobby Kwanghoon, Yi, Kayoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823527/
https://www.ncbi.nlm.nih.gov/pubmed/33374330
http://dx.doi.org/10.3390/diagnostics11010020
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author Shin, Young Joo
Kim, Eunbi
Han, Bobby Kwanghoon
Yi, Kayoung
author_facet Shin, Young Joo
Kim, Eunbi
Han, Bobby Kwanghoon
Yi, Kayoung
author_sort Shin, Young Joo
collection PubMed
description Despite the importance of the early detection of glaucoma, most patients with progressive glaucoma show minimal symptoms. We aimed to evaluate biomarkers for glaucoma diagnosis in Korea. Forty-two volunteers with/without open-angle glaucoma were enrolled from January through October 2015—divided into a control or open-angle glaucoma group, which was further divided into normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) groups—and underwent assessments for myelin basic protein (MBP), heat shock protein 60, anti-Sjögren’s-syndrome-related antigen A (SSA) and antigen B (SSB), anti-α-fodrin, and anti-nucleic acid. The glaucoma group showed a higher serum MBP level and lower serum anti-α-fodrin antibody level than the control group (p < 0.05). The NTG group showed higher serum anti-SSA and anti-SSB levels and lower anti-α-fodrin IgG/IgA levels than the HTG group. In the receiver operating characteristic curve analysis, the area under the curve (AUC) for serum MBP level was 0.917 in discriminating between controls and patients with glaucoma. Between the NTG and HTG groups, anti-SSA, anti-SSB, and anti-α-fodrin IgG/IgA levels showed an AUC above 0.8. Thus, these biomarkers were useful for diagnosing glaucoma and discriminating between controls and patients with glaucoma, and patients with NTG and HTG.
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spelling pubmed-78235272021-01-24 Serum Biomarkers for the Diagnosis of Glaucoma Shin, Young Joo Kim, Eunbi Han, Bobby Kwanghoon Yi, Kayoung Diagnostics (Basel) Article Despite the importance of the early detection of glaucoma, most patients with progressive glaucoma show minimal symptoms. We aimed to evaluate biomarkers for glaucoma diagnosis in Korea. Forty-two volunteers with/without open-angle glaucoma were enrolled from January through October 2015—divided into a control or open-angle glaucoma group, which was further divided into normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) groups—and underwent assessments for myelin basic protein (MBP), heat shock protein 60, anti-Sjögren’s-syndrome-related antigen A (SSA) and antigen B (SSB), anti-α-fodrin, and anti-nucleic acid. The glaucoma group showed a higher serum MBP level and lower serum anti-α-fodrin antibody level than the control group (p < 0.05). The NTG group showed higher serum anti-SSA and anti-SSB levels and lower anti-α-fodrin IgG/IgA levels than the HTG group. In the receiver operating characteristic curve analysis, the area under the curve (AUC) for serum MBP level was 0.917 in discriminating between controls and patients with glaucoma. Between the NTG and HTG groups, anti-SSA, anti-SSB, and anti-α-fodrin IgG/IgA levels showed an AUC above 0.8. Thus, these biomarkers were useful for diagnosing glaucoma and discriminating between controls and patients with glaucoma, and patients with NTG and HTG. MDPI 2020-12-24 /pmc/articles/PMC7823527/ /pubmed/33374330 http://dx.doi.org/10.3390/diagnostics11010020 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shin, Young Joo
Kim, Eunbi
Han, Bobby Kwanghoon
Yi, Kayoung
Serum Biomarkers for the Diagnosis of Glaucoma
title Serum Biomarkers for the Diagnosis of Glaucoma
title_full Serum Biomarkers for the Diagnosis of Glaucoma
title_fullStr Serum Biomarkers for the Diagnosis of Glaucoma
title_full_unstemmed Serum Biomarkers for the Diagnosis of Glaucoma
title_short Serum Biomarkers for the Diagnosis of Glaucoma
title_sort serum biomarkers for the diagnosis of glaucoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823527/
https://www.ncbi.nlm.nih.gov/pubmed/33374330
http://dx.doi.org/10.3390/diagnostics11010020
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