Cargando…

Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer

The nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor central to inflammation and various malignant diseases in humans. The regulation of NF-κB can be influenced by a myriad of post-translational modifications (PTMs), including phosphorylation, one of the most popular PTM formats i...

Descripción completa

Detalles Bibliográficos
Autores principales: Motolani, Aishat, Martin, Matthew, Sun, Mengyao, Lu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823564/
https://www.ncbi.nlm.nih.gov/pubmed/33375283
http://dx.doi.org/10.3390/biom11010015
_version_ 1783639865656606720
author Motolani, Aishat
Martin, Matthew
Sun, Mengyao
Lu, Tao
author_facet Motolani, Aishat
Martin, Matthew
Sun, Mengyao
Lu, Tao
author_sort Motolani, Aishat
collection PubMed
description The nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor central to inflammation and various malignant diseases in humans. The regulation of NF-κB can be influenced by a myriad of post-translational modifications (PTMs), including phosphorylation, one of the most popular PTM formats in NF-κB signaling. The regulation by phosphorylation modification is not limited to NF-κB subunits, but it also encompasses the diverse regulators of NF-κB signaling. The differential site-specific phosphorylation of NF-κB itself or some NF-κB regulators can result in dysregulated NF-κB signaling, often culminating in events that induce cancer progression and other hyper NF-κB related diseases, such as inflammation, cardiovascular diseases, diabetes, as well as neurodegenerative diseases, etc. In this review, we discuss the regulatory role of phosphorylation in NF-κB signaling and the mechanisms through which they aid cancer progression. Additionally, we highlight some of the known and novel NF-κB regulators that are frequently subjected to phosphorylation. Finally, we provide some future perspectives in terms of drug development to target kinases that regulate NF-κB signaling for cancer therapeutic purposes.
format Online
Article
Text
id pubmed-7823564
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-78235642021-01-24 Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer Motolani, Aishat Martin, Matthew Sun, Mengyao Lu, Tao Biomolecules Review The nuclear factor kappa B (NF-κB) is a ubiquitous transcription factor central to inflammation and various malignant diseases in humans. The regulation of NF-κB can be influenced by a myriad of post-translational modifications (PTMs), including phosphorylation, one of the most popular PTM formats in NF-κB signaling. The regulation by phosphorylation modification is not limited to NF-κB subunits, but it also encompasses the diverse regulators of NF-κB signaling. The differential site-specific phosphorylation of NF-κB itself or some NF-κB regulators can result in dysregulated NF-κB signaling, often culminating in events that induce cancer progression and other hyper NF-κB related diseases, such as inflammation, cardiovascular diseases, diabetes, as well as neurodegenerative diseases, etc. In this review, we discuss the regulatory role of phosphorylation in NF-κB signaling and the mechanisms through which they aid cancer progression. Additionally, we highlight some of the known and novel NF-κB regulators that are frequently subjected to phosphorylation. Finally, we provide some future perspectives in terms of drug development to target kinases that regulate NF-κB signaling for cancer therapeutic purposes. MDPI 2020-12-26 /pmc/articles/PMC7823564/ /pubmed/33375283 http://dx.doi.org/10.3390/biom11010015 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Motolani, Aishat
Martin, Matthew
Sun, Mengyao
Lu, Tao
Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer
title Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer
title_full Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer
title_fullStr Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer
title_full_unstemmed Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer
title_short Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer
title_sort phosphorylation of the regulators, a complex facet of nf-κb signaling in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823564/
https://www.ncbi.nlm.nih.gov/pubmed/33375283
http://dx.doi.org/10.3390/biom11010015
work_keys_str_mv AT motolaniaishat phosphorylationoftheregulatorsacomplexfacetofnfkbsignalingincancer
AT martinmatthew phosphorylationoftheregulatorsacomplexfacetofnfkbsignalingincancer
AT sunmengyao phosphorylationoftheregulatorsacomplexfacetofnfkbsignalingincancer
AT lutao phosphorylationoftheregulatorsacomplexfacetofnfkbsignalingincancer