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Developmental Origins of Kidney Disease: Why Oxidative Stress Matters?

The “developmental origins of health and disease” theory indicates that many adult-onset diseases can originate in the earliest stages of life. The developing kidney has emerged as being particularly vulnerable to adverse in utero conditions leading to morphological and functional changes, namely re...

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Autores principales: Hsu, Chien-Ning, Tain, You-Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823649/
https://www.ncbi.nlm.nih.gov/pubmed/33396856
http://dx.doi.org/10.3390/antiox10010033
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author Hsu, Chien-Ning
Tain, You-Lin
author_facet Hsu, Chien-Ning
Tain, You-Lin
author_sort Hsu, Chien-Ning
collection PubMed
description The “developmental origins of health and disease” theory indicates that many adult-onset diseases can originate in the earliest stages of life. The developing kidney has emerged as being particularly vulnerable to adverse in utero conditions leading to morphological and functional changes, namely renal programming. Emerging evidence indicates oxidative stress, an imbalance between reactive oxygen/nitrogen species (ROS/RNS) and antioxidant systems, plays a pathogenetic role in the developmental programming of kidney disease. Conversely, perinatal use of antioxidants has been implemented to reverse programming processes and prevent adult-onset diseases. We have termed this reprogramming. The focus of this review is twofold: (1) To summarize the current knowledge on oxidative stress implicated in renal programming and kidney disease of developmental origins; and (2) to provide an overview of reprogramming effects of perinatal antioxidant therapy on renal programming and how this may prevent adult-onset kidney disease. Although early-life oxidative stress is implicated in mediating renal programming and adverse offspring renal outcomes, and animal models provide promising results to allow perinatal antioxidants applied as potential reprogramming interventions, it is still awaiting clinical translation. This presents exciting new challenges and areas for future research.
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spelling pubmed-78236492021-01-24 Developmental Origins of Kidney Disease: Why Oxidative Stress Matters? Hsu, Chien-Ning Tain, You-Lin Antioxidants (Basel) Review The “developmental origins of health and disease” theory indicates that many adult-onset diseases can originate in the earliest stages of life. The developing kidney has emerged as being particularly vulnerable to adverse in utero conditions leading to morphological and functional changes, namely renal programming. Emerging evidence indicates oxidative stress, an imbalance between reactive oxygen/nitrogen species (ROS/RNS) and antioxidant systems, plays a pathogenetic role in the developmental programming of kidney disease. Conversely, perinatal use of antioxidants has been implemented to reverse programming processes and prevent adult-onset diseases. We have termed this reprogramming. The focus of this review is twofold: (1) To summarize the current knowledge on oxidative stress implicated in renal programming and kidney disease of developmental origins; and (2) to provide an overview of reprogramming effects of perinatal antioxidant therapy on renal programming and how this may prevent adult-onset kidney disease. Although early-life oxidative stress is implicated in mediating renal programming and adverse offspring renal outcomes, and animal models provide promising results to allow perinatal antioxidants applied as potential reprogramming interventions, it is still awaiting clinical translation. This presents exciting new challenges and areas for future research. MDPI 2020-12-30 /pmc/articles/PMC7823649/ /pubmed/33396856 http://dx.doi.org/10.3390/antiox10010033 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hsu, Chien-Ning
Tain, You-Lin
Developmental Origins of Kidney Disease: Why Oxidative Stress Matters?
title Developmental Origins of Kidney Disease: Why Oxidative Stress Matters?
title_full Developmental Origins of Kidney Disease: Why Oxidative Stress Matters?
title_fullStr Developmental Origins of Kidney Disease: Why Oxidative Stress Matters?
title_full_unstemmed Developmental Origins of Kidney Disease: Why Oxidative Stress Matters?
title_short Developmental Origins of Kidney Disease: Why Oxidative Stress Matters?
title_sort developmental origins of kidney disease: why oxidative stress matters?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823649/
https://www.ncbi.nlm.nih.gov/pubmed/33396856
http://dx.doi.org/10.3390/antiox10010033
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