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The Molecular Mechanisms Associated with Aerobic Exercise-Induced Cardiac Regeneration
The leading cause of heart failure is cardiomyopathy and damage to the cardiomyocytes. Adult mammalian cardiomyocytes have the ability to regenerate, but this cannot wholly compensate for myocardial cell loss after myocardial injury. Studies have shown that exercise has a regulatory role in the acti...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823705/ https://www.ncbi.nlm.nih.gov/pubmed/33375497 http://dx.doi.org/10.3390/biom11010019 |
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author | Bo, Bing Zhou, Yang Zheng, Qingyun Wang, Guandong Zhou, Ke Wei, Jianshe |
author_facet | Bo, Bing Zhou, Yang Zheng, Qingyun Wang, Guandong Zhou, Ke Wei, Jianshe |
author_sort | Bo, Bing |
collection | PubMed |
description | The leading cause of heart failure is cardiomyopathy and damage to the cardiomyocytes. Adult mammalian cardiomyocytes have the ability to regenerate, but this cannot wholly compensate for myocardial cell loss after myocardial injury. Studies have shown that exercise has a regulatory role in the activation and promotion of regeneration of healthy and injured adult cardiomyocytes. However, current research on the effects of aerobic exercise in myocardial regeneration is not comprehensive. This review discusses the relationships between aerobic exercise and the regeneration of cardiomyocytes with respect to complex molecular and cellular mechanisms, paracrine factors, transcriptional factors, signaling pathways, and microRNAs that induce cardiac regeneration. The topics discussed herein provide a knowledge base for physical activity-induced cardiomyocyte regeneration, in which exercise enhances overall heart function and improves the efficacy of cardiac rehabilitation. |
format | Online Article Text |
id | pubmed-7823705 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78237052021-01-24 The Molecular Mechanisms Associated with Aerobic Exercise-Induced Cardiac Regeneration Bo, Bing Zhou, Yang Zheng, Qingyun Wang, Guandong Zhou, Ke Wei, Jianshe Biomolecules Review The leading cause of heart failure is cardiomyopathy and damage to the cardiomyocytes. Adult mammalian cardiomyocytes have the ability to regenerate, but this cannot wholly compensate for myocardial cell loss after myocardial injury. Studies have shown that exercise has a regulatory role in the activation and promotion of regeneration of healthy and injured adult cardiomyocytes. However, current research on the effects of aerobic exercise in myocardial regeneration is not comprehensive. This review discusses the relationships between aerobic exercise and the regeneration of cardiomyocytes with respect to complex molecular and cellular mechanisms, paracrine factors, transcriptional factors, signaling pathways, and microRNAs that induce cardiac regeneration. The topics discussed herein provide a knowledge base for physical activity-induced cardiomyocyte regeneration, in which exercise enhances overall heart function and improves the efficacy of cardiac rehabilitation. MDPI 2020-12-27 /pmc/articles/PMC7823705/ /pubmed/33375497 http://dx.doi.org/10.3390/biom11010019 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bo, Bing Zhou, Yang Zheng, Qingyun Wang, Guandong Zhou, Ke Wei, Jianshe The Molecular Mechanisms Associated with Aerobic Exercise-Induced Cardiac Regeneration |
title | The Molecular Mechanisms Associated with Aerobic Exercise-Induced Cardiac Regeneration |
title_full | The Molecular Mechanisms Associated with Aerobic Exercise-Induced Cardiac Regeneration |
title_fullStr | The Molecular Mechanisms Associated with Aerobic Exercise-Induced Cardiac Regeneration |
title_full_unstemmed | The Molecular Mechanisms Associated with Aerobic Exercise-Induced Cardiac Regeneration |
title_short | The Molecular Mechanisms Associated with Aerobic Exercise-Induced Cardiac Regeneration |
title_sort | molecular mechanisms associated with aerobic exercise-induced cardiac regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823705/ https://www.ncbi.nlm.nih.gov/pubmed/33375497 http://dx.doi.org/10.3390/biom11010019 |
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