Cargando…

Functional Magnetic Resonance Imaging in the Olfactory Perception of the Same Stimuli

Background. Data in the literature report that a number of studies have attempted to identify the exact location of the cortical olfaction representation, searching for evidence suggesting that sniffing odors can initiate a primary activation of the piriform cortex and the insula. Nowadays, due to t...

Descripción completa

Detalles Bibliográficos
Autores principales: Ciorba, Andrea, Hatzopoulos, Stavros, Cogliandolo, Cristina, Bianchini, Chiara, Renna, Martina, Perrucci, Luca, Skarzynska, Magdalena, Skarżyński, Piotr Henryk, Campioni, Paolo, Cittanti, Corrado, Carnevale, Aldo, Giganti, Melchiore, Pelucchi, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823816/
https://www.ncbi.nlm.nih.gov/pubmed/33375540
http://dx.doi.org/10.3390/life11010011
_version_ 1783639926272688128
author Ciorba, Andrea
Hatzopoulos, Stavros
Cogliandolo, Cristina
Bianchini, Chiara
Renna, Martina
Perrucci, Luca
Skarzynska, Magdalena
Skarżyński, Piotr Henryk
Campioni, Paolo
Cittanti, Corrado
Carnevale, Aldo
Giganti, Melchiore
Pelucchi, Stefano
author_facet Ciorba, Andrea
Hatzopoulos, Stavros
Cogliandolo, Cristina
Bianchini, Chiara
Renna, Martina
Perrucci, Luca
Skarzynska, Magdalena
Skarżyński, Piotr Henryk
Campioni, Paolo
Cittanti, Corrado
Carnevale, Aldo
Giganti, Melchiore
Pelucchi, Stefano
author_sort Ciorba, Andrea
collection PubMed
description Background. Data in the literature report that a number of studies have attempted to identify the exact location of the cortical olfaction representation, searching for evidence suggesting that sniffing odors can initiate a primary activation of the piriform cortex and the insula. Nowadays, due to the SARS-CoV-2 (COVID-19) outbreak, the functional study of the olfactory system could offer a better understanding of the physiopathology of olfactory perception, elucidating better the possible site(s) of damage induced by the COVID-19 infection. The aim of this paper was to evaluate brain maps generated from functional Magnetic Resonance Imaging (fMRI) data, collected from healthy individuals in response to the same olfactory stimulus. Methods. A total of 45 healthy volunteers, without history and/or no clinical signs of sinonasal disease and without history and/or presence of olfactory dysfunction underwent fMRI assessment. Subjects were presented with the same odorous stimuli at specific intervals. fMRI generated brain maps were used in the identification of different cortical areas, involved in the stimuli perception. Results. The fMRI brain maps showed that odorous stimuli activate primarily the left anterior insula (in 35/45 cases or 77.8%). Other activated areas include: the low temporal gyri, the middle and superior temporal gyri, the frontal and piriform cortex, the anterior cingulate gyrus, the parahippocampal gyrus, the temporopolar area, the para-insular area, the subcentral area, the supramarginal gyrus, the occipital cortex and the cerebellum. Conclusions. fMRI resulted as a safe and reliable means to study the perception of olfaction in the cortex. The data of this study suggest that the anterior insula is the main stimulated area when olfactory stimuli are present. This area is always activated, despite the hand and nostril dominance.
format Online
Article
Text
id pubmed-7823816
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-78238162021-01-24 Functional Magnetic Resonance Imaging in the Olfactory Perception of the Same Stimuli Ciorba, Andrea Hatzopoulos, Stavros Cogliandolo, Cristina Bianchini, Chiara Renna, Martina Perrucci, Luca Skarzynska, Magdalena Skarżyński, Piotr Henryk Campioni, Paolo Cittanti, Corrado Carnevale, Aldo Giganti, Melchiore Pelucchi, Stefano Life (Basel) Article Background. Data in the literature report that a number of studies have attempted to identify the exact location of the cortical olfaction representation, searching for evidence suggesting that sniffing odors can initiate a primary activation of the piriform cortex and the insula. Nowadays, due to the SARS-CoV-2 (COVID-19) outbreak, the functional study of the olfactory system could offer a better understanding of the physiopathology of olfactory perception, elucidating better the possible site(s) of damage induced by the COVID-19 infection. The aim of this paper was to evaluate brain maps generated from functional Magnetic Resonance Imaging (fMRI) data, collected from healthy individuals in response to the same olfactory stimulus. Methods. A total of 45 healthy volunteers, without history and/or no clinical signs of sinonasal disease and without history and/or presence of olfactory dysfunction underwent fMRI assessment. Subjects were presented with the same odorous stimuli at specific intervals. fMRI generated brain maps were used in the identification of different cortical areas, involved in the stimuli perception. Results. The fMRI brain maps showed that odorous stimuli activate primarily the left anterior insula (in 35/45 cases or 77.8%). Other activated areas include: the low temporal gyri, the middle and superior temporal gyri, the frontal and piriform cortex, the anterior cingulate gyrus, the parahippocampal gyrus, the temporopolar area, the para-insular area, the subcentral area, the supramarginal gyrus, the occipital cortex and the cerebellum. Conclusions. fMRI resulted as a safe and reliable means to study the perception of olfaction in the cortex. The data of this study suggest that the anterior insula is the main stimulated area when olfactory stimuli are present. This area is always activated, despite the hand and nostril dominance. MDPI 2020-12-25 /pmc/articles/PMC7823816/ /pubmed/33375540 http://dx.doi.org/10.3390/life11010011 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ciorba, Andrea
Hatzopoulos, Stavros
Cogliandolo, Cristina
Bianchini, Chiara
Renna, Martina
Perrucci, Luca
Skarzynska, Magdalena
Skarżyński, Piotr Henryk
Campioni, Paolo
Cittanti, Corrado
Carnevale, Aldo
Giganti, Melchiore
Pelucchi, Stefano
Functional Magnetic Resonance Imaging in the Olfactory Perception of the Same Stimuli
title Functional Magnetic Resonance Imaging in the Olfactory Perception of the Same Stimuli
title_full Functional Magnetic Resonance Imaging in the Olfactory Perception of the Same Stimuli
title_fullStr Functional Magnetic Resonance Imaging in the Olfactory Perception of the Same Stimuli
title_full_unstemmed Functional Magnetic Resonance Imaging in the Olfactory Perception of the Same Stimuli
title_short Functional Magnetic Resonance Imaging in the Olfactory Perception of the Same Stimuli
title_sort functional magnetic resonance imaging in the olfactory perception of the same stimuli
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823816/
https://www.ncbi.nlm.nih.gov/pubmed/33375540
http://dx.doi.org/10.3390/life11010011
work_keys_str_mv AT ciorbaandrea functionalmagneticresonanceimagingintheolfactoryperceptionofthesamestimuli
AT hatzopoulosstavros functionalmagneticresonanceimagingintheolfactoryperceptionofthesamestimuli
AT cogliandolocristina functionalmagneticresonanceimagingintheolfactoryperceptionofthesamestimuli
AT bianchinichiara functionalmagneticresonanceimagingintheolfactoryperceptionofthesamestimuli
AT rennamartina functionalmagneticresonanceimagingintheolfactoryperceptionofthesamestimuli
AT perrucciluca functionalmagneticresonanceimagingintheolfactoryperceptionofthesamestimuli
AT skarzynskamagdalena functionalmagneticresonanceimagingintheolfactoryperceptionofthesamestimuli
AT skarzynskipiotrhenryk functionalmagneticresonanceimagingintheolfactoryperceptionofthesamestimuli
AT campionipaolo functionalmagneticresonanceimagingintheolfactoryperceptionofthesamestimuli
AT cittanticorrado functionalmagneticresonanceimagingintheolfactoryperceptionofthesamestimuli
AT carnevalealdo functionalmagneticresonanceimagingintheolfactoryperceptionofthesamestimuli
AT gigantimelchiore functionalmagneticresonanceimagingintheolfactoryperceptionofthesamestimuli
AT pelucchistefano functionalmagneticresonanceimagingintheolfactoryperceptionofthesamestimuli