Cargando…

Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity

Cerebral palsy (CP) is a frequent cause of childhood disability often associated with a complex group of disorders, including epilepsy, which is reported to impact approximately 40% of affected individuals. This retrospective study involved a group of children affected by CP, some of whom also had c...

Descripción completa

Detalles Bibliográficos
Autores principales: Pavone, Piero, Gulizia, Carmela, Le Pira, Alice, Greco, Filippo, Parisi, Pasquale, Di Cara, Giuseppe, Falsaperla, Raffaele, Lubrano, Riccardo, Minardi, Carmelo, Spalice, Alberto, Ruggieri, Martino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823826/
https://www.ncbi.nlm.nih.gov/pubmed/33396243
http://dx.doi.org/10.3390/children8010016
_version_ 1783639928652955648
author Pavone, Piero
Gulizia, Carmela
Le Pira, Alice
Greco, Filippo
Parisi, Pasquale
Di Cara, Giuseppe
Falsaperla, Raffaele
Lubrano, Riccardo
Minardi, Carmelo
Spalice, Alberto
Ruggieri, Martino
author_facet Pavone, Piero
Gulizia, Carmela
Le Pira, Alice
Greco, Filippo
Parisi, Pasquale
Di Cara, Giuseppe
Falsaperla, Raffaele
Lubrano, Riccardo
Minardi, Carmelo
Spalice, Alberto
Ruggieri, Martino
author_sort Pavone, Piero
collection PubMed
description Cerebral palsy (CP) is a frequent cause of childhood disability often associated with a complex group of disorders, including epilepsy, which is reported to impact approximately 40% of affected individuals. This retrospective study involved a group of children affected by CP, some of whom also had comorbid epilepsy. The aim of this study was to report our experience of analyzing, in particular, (a) some of the clinical aspects of the different type of CP, and (b) the relationship between the clinical data of children affected by CP plus epilepsy and each type of CP. Methods: This retrospective single-center study was performed with 93 children admitted to the Pediatric Department of the University of Catania, Italy, affected by CP and distinguished according to the type of motor clinical presentation, with 46 showing epileptic seizures, compared to a control group of 136 children affected by epilepsy without other neurologic disorders. Results: Among the 93 CP children, 25 (27%) had spastic quadriplegia (plus one patient with dystonic quadriplegia), 39 (42%) had spastic hemiplegia, 11 (12%) had spastic diplegia (plus two with ataxia and one with dyskinetic CP), and 14 (15%) did not have a well-defined type of CP. The frequency of epilepsy was higher in affected CP children who showed major motor dysfunction (GMFCS IV–V types). As regards the 46 children with CP plus epilepsy, compared to the group of the control, the age of epilepsy onset was found to be statistically significant: 21 ± 35.1 months vs. 67 ± 39.7. Conclusions: Epilepsy represents one of the most frequent comorbidities of cerebral palsy. In children with CP, particular attention should be paid to the early identification and treatment of comorbid epilepsy.
format Online
Article
Text
id pubmed-7823826
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-78238262021-01-24 Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity Pavone, Piero Gulizia, Carmela Le Pira, Alice Greco, Filippo Parisi, Pasquale Di Cara, Giuseppe Falsaperla, Raffaele Lubrano, Riccardo Minardi, Carmelo Spalice, Alberto Ruggieri, Martino Children (Basel) Article Cerebral palsy (CP) is a frequent cause of childhood disability often associated with a complex group of disorders, including epilepsy, which is reported to impact approximately 40% of affected individuals. This retrospective study involved a group of children affected by CP, some of whom also had comorbid epilepsy. The aim of this study was to report our experience of analyzing, in particular, (a) some of the clinical aspects of the different type of CP, and (b) the relationship between the clinical data of children affected by CP plus epilepsy and each type of CP. Methods: This retrospective single-center study was performed with 93 children admitted to the Pediatric Department of the University of Catania, Italy, affected by CP and distinguished according to the type of motor clinical presentation, with 46 showing epileptic seizures, compared to a control group of 136 children affected by epilepsy without other neurologic disorders. Results: Among the 93 CP children, 25 (27%) had spastic quadriplegia (plus one patient with dystonic quadriplegia), 39 (42%) had spastic hemiplegia, 11 (12%) had spastic diplegia (plus two with ataxia and one with dyskinetic CP), and 14 (15%) did not have a well-defined type of CP. The frequency of epilepsy was higher in affected CP children who showed major motor dysfunction (GMFCS IV–V types). As regards the 46 children with CP plus epilepsy, compared to the group of the control, the age of epilepsy onset was found to be statistically significant: 21 ± 35.1 months vs. 67 ± 39.7. Conclusions: Epilepsy represents one of the most frequent comorbidities of cerebral palsy. In children with CP, particular attention should be paid to the early identification and treatment of comorbid epilepsy. MDPI 2020-12-31 /pmc/articles/PMC7823826/ /pubmed/33396243 http://dx.doi.org/10.3390/children8010016 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pavone, Piero
Gulizia, Carmela
Le Pira, Alice
Greco, Filippo
Parisi, Pasquale
Di Cara, Giuseppe
Falsaperla, Raffaele
Lubrano, Riccardo
Minardi, Carmelo
Spalice, Alberto
Ruggieri, Martino
Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity
title Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity
title_full Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity
title_fullStr Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity
title_full_unstemmed Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity
title_short Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity
title_sort cerebral palsy and epilepsy in children: clinical perspectives on a common comorbidity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823826/
https://www.ncbi.nlm.nih.gov/pubmed/33396243
http://dx.doi.org/10.3390/children8010016
work_keys_str_mv AT pavonepiero cerebralpalsyandepilepsyinchildrenclinicalperspectivesonacommoncomorbidity
AT guliziacarmela cerebralpalsyandepilepsyinchildrenclinicalperspectivesonacommoncomorbidity
AT lepiraalice cerebralpalsyandepilepsyinchildrenclinicalperspectivesonacommoncomorbidity
AT grecofilippo cerebralpalsyandepilepsyinchildrenclinicalperspectivesonacommoncomorbidity
AT parisipasquale cerebralpalsyandepilepsyinchildrenclinicalperspectivesonacommoncomorbidity
AT dicaragiuseppe cerebralpalsyandepilepsyinchildrenclinicalperspectivesonacommoncomorbidity
AT falsaperlaraffaele cerebralpalsyandepilepsyinchildrenclinicalperspectivesonacommoncomorbidity
AT lubranoriccardo cerebralpalsyandepilepsyinchildrenclinicalperspectivesonacommoncomorbidity
AT minardicarmelo cerebralpalsyandepilepsyinchildrenclinicalperspectivesonacommoncomorbidity
AT spalicealberto cerebralpalsyandepilepsyinchildrenclinicalperspectivesonacommoncomorbidity
AT ruggierimartino cerebralpalsyandepilepsyinchildrenclinicalperspectivesonacommoncomorbidity