Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience

A key limitation to glioma treatment involves the blood brain barrier (BBB). Convection enhanced delivery (CED) is a technique that uses a catheter placed directly into the brain parenchyma to infuse treatments using a pressure gradient. In this manuscript, we describe the physical principles behind...

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Detalles Bibliográficos
Autores principales: Upadhyayula, Pavan S., Spinazzi, Eleonora F., Argenziano, Michael G., Canoll, Peter, Bruce, Jeffrey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823846/
https://www.ncbi.nlm.nih.gov/pubmed/33396668
http://dx.doi.org/10.3390/pharmaceutics13010039
Descripción
Sumario:A key limitation to glioma treatment involves the blood brain barrier (BBB). Convection enhanced delivery (CED) is a technique that uses a catheter placed directly into the brain parenchyma to infuse treatments using a pressure gradient. In this manuscript, we describe the physical principles behind CED along with the common pitfalls and methods for optimizing convection. Finally, we highlight our institutional experience using topotecan CED for the treatment of malignant glioma.

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