Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience

A key limitation to glioma treatment involves the blood brain barrier (BBB). Convection enhanced delivery (CED) is a technique that uses a catheter placed directly into the brain parenchyma to infuse treatments using a pressure gradient. In this manuscript, we describe the physical principles behind...

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Detalles Bibliográficos
Autores principales: Upadhyayula, Pavan S., Spinazzi, Eleonora F., Argenziano, Michael G., Canoll, Peter, Bruce, Jeffrey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823846/
https://www.ncbi.nlm.nih.gov/pubmed/33396668
http://dx.doi.org/10.3390/pharmaceutics13010039
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author Upadhyayula, Pavan S.
Spinazzi, Eleonora F.
Argenziano, Michael G.
Canoll, Peter
Bruce, Jeffrey N.
author_facet Upadhyayula, Pavan S.
Spinazzi, Eleonora F.
Argenziano, Michael G.
Canoll, Peter
Bruce, Jeffrey N.
author_sort Upadhyayula, Pavan S.
collection PubMed
description A key limitation to glioma treatment involves the blood brain barrier (BBB). Convection enhanced delivery (CED) is a technique that uses a catheter placed directly into the brain parenchyma to infuse treatments using a pressure gradient. In this manuscript, we describe the physical principles behind CED along with the common pitfalls and methods for optimizing convection. Finally, we highlight our institutional experience using topotecan CED for the treatment of malignant glioma.
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spelling pubmed-78238462021-01-24 Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience Upadhyayula, Pavan S. Spinazzi, Eleonora F. Argenziano, Michael G. Canoll, Peter Bruce, Jeffrey N. Pharmaceutics Review A key limitation to glioma treatment involves the blood brain barrier (BBB). Convection enhanced delivery (CED) is a technique that uses a catheter placed directly into the brain parenchyma to infuse treatments using a pressure gradient. In this manuscript, we describe the physical principles behind CED along with the common pitfalls and methods for optimizing convection. Finally, we highlight our institutional experience using topotecan CED for the treatment of malignant glioma. MDPI 2020-12-30 /pmc/articles/PMC7823846/ /pubmed/33396668 http://dx.doi.org/10.3390/pharmaceutics13010039 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Upadhyayula, Pavan S.
Spinazzi, Eleonora F.
Argenziano, Michael G.
Canoll, Peter
Bruce, Jeffrey N.
Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience
title Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience
title_full Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience
title_fullStr Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience
title_full_unstemmed Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience
title_short Convection Enhanced Delivery of Topotecan for Gliomas: A Single-Center Experience
title_sort convection enhanced delivery of topotecan for gliomas: a single-center experience
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7823846/
https://www.ncbi.nlm.nih.gov/pubmed/33396668
http://dx.doi.org/10.3390/pharmaceutics13010039
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AT canollpeter convectionenhanceddeliveryoftopotecanforgliomasasinglecenterexperience
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