Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications

This review outlines the accomplishments and potential developments of targeted alpha (α) particle therapy (TAT). It discusses the therapeutic advantages of the short and highly ionizing path of α-particle emissions; the ability of TAT to complement and provide superior efficacy over existing forms...

Descripción completa

Detalles Bibliográficos
Autores principales: Nelson, Bryce J. B., Andersson, Jan D., Wuest, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824049/
https://www.ncbi.nlm.nih.gov/pubmed/33396374
http://dx.doi.org/10.3390/pharmaceutics13010049
_version_ 1783639981975142400
author Nelson, Bryce J. B.
Andersson, Jan D.
Wuest, Frank
author_facet Nelson, Bryce J. B.
Andersson, Jan D.
Wuest, Frank
author_sort Nelson, Bryce J. B.
collection PubMed
description This review outlines the accomplishments and potential developments of targeted alpha (α) particle therapy (TAT). It discusses the therapeutic advantages of the short and highly ionizing path of α-particle emissions; the ability of TAT to complement and provide superior efficacy over existing forms of radiotherapy; the physical decay properties and radiochemistry of common α-emitters, including (225)Ac, (213)Bi, (224)Ra, (212)Pb, (227)Th, (223)Ra, (211)At, and (149)Tb; the production techniques and proper handling of α-emitters in a radiopharmacy; recent preclinical developments; ongoing and completed clinical trials; and an outlook on the future of TAT.
format Online
Article
Text
id pubmed-7824049
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-78240492021-01-24 Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications Nelson, Bryce J. B. Andersson, Jan D. Wuest, Frank Pharmaceutics Review This review outlines the accomplishments and potential developments of targeted alpha (α) particle therapy (TAT). It discusses the therapeutic advantages of the short and highly ionizing path of α-particle emissions; the ability of TAT to complement and provide superior efficacy over existing forms of radiotherapy; the physical decay properties and radiochemistry of common α-emitters, including (225)Ac, (213)Bi, (224)Ra, (212)Pb, (227)Th, (223)Ra, (211)At, and (149)Tb; the production techniques and proper handling of α-emitters in a radiopharmacy; recent preclinical developments; ongoing and completed clinical trials; and an outlook on the future of TAT. MDPI 2020-12-31 /pmc/articles/PMC7824049/ /pubmed/33396374 http://dx.doi.org/10.3390/pharmaceutics13010049 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nelson, Bryce J. B.
Andersson, Jan D.
Wuest, Frank
Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications
title Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications
title_full Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications
title_fullStr Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications
title_full_unstemmed Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications
title_short Targeted Alpha Therapy: Progress in Radionuclide Production, Radiochemistry, and Applications
title_sort targeted alpha therapy: progress in radionuclide production, radiochemistry, and applications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824049/
https://www.ncbi.nlm.nih.gov/pubmed/33396374
http://dx.doi.org/10.3390/pharmaceutics13010049
work_keys_str_mv AT nelsonbrycejb targetedalphatherapyprogressinradionuclideproductionradiochemistryandapplications
AT anderssonjand targetedalphatherapyprogressinradionuclideproductionradiochemistryandapplications
AT wuestfrank targetedalphatherapyprogressinradionuclideproductionradiochemistryandapplications

Ejemplares similares