Metabolic Detoxification of 2-Oxobutyrate by Remodeling Escherichia coli Acetate Bypass

2-Oxobutyrate (2-OBA), as a toxic metabolic intermediate, generally arrests the cell growth of most microorganisms and blocks the biosynthesis of target metabolites. In this study, we demonstrated that using the acetate bypass to replace the pyruvate dehydrogenase complex (PDHc) in Escherichia coli...

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Detalles Bibliográficos
Autores principales: Fang, Yu, Zhang, Shuyan, Wang, Jianli, Yin, Lianghong, Zhang, Hailing, Wang, Zhen, Song, Jie, Hu, Xiaoqing, Wang, Xiaoyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824062/
https://www.ncbi.nlm.nih.gov/pubmed/33406667
http://dx.doi.org/10.3390/metabo11010030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824062/
https://www.ncbi.nlm.nih.gov/pubmed/33406667
http://dx.doi.org/10.3390/metabo11010030

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