Cargando…

Metabolic Detoxification of 2-Oxobutyrate by Remodeling Escherichia coli Acetate Bypass

2-Oxobutyrate (2-OBA), as a toxic metabolic intermediate, generally arrests the cell growth of most microorganisms and blocks the biosynthesis of target metabolites. In this study, we demonstrated that using the acetate bypass to replace the pyruvate dehydrogenase complex (PDHc) in Escherichia coli...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fang, Yu, Zhang, Shuyan, Wang, Jianli, Yin, Lianghong, Zhang, Hailing, Wang, Zhen, Song, Jie, Hu, Xiaoqing, Wang, Xiaoyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824062/ https://www.ncbi.nlm.nih.gov/pubmed/33406667 http://dx.doi.org/10.3390/metabo11010030

Ejemplares similares

Methyl 2-[(E)-(4-nitrophenyl)hydrazono]-3-oxobutyrate
por: Liu, Yong-Hong, et al.
Publicado: (2008)

Improving l-threonine production in Escherichia coli by elimination of transporters ProP and ProVWX
por: Wang, Shuaiwen, et al.
Publicado: (2021)

Insights into the structure of Escherichia coli outer membrane as the target for engineering microbial cell factories
por: Wang, Jianli, et al.
Publicado: (2021)

Influence of Core Oligosaccharide of Lipopolysaccharide to Outer Membrane Behavior of Escherichia coli
por: Wang, Zhou, et al.
Publicado: (2015)

Effects of lipopolysaccharide structure on lycopene production in Escherichia coli
por: Cui, Mao, et al.
Publicado: (2019)

Reconstruction of the Carotenoid Biosynthetic Pathway of Cronobacter sakazakii BAA894 in Escherichia coli
por: Zhang, Wei, et al.
Publicado: (2014)

Construction and Characterization of an Escherichia coli Mutant Producing Kdo(2)-Lipid A
por: Wang, Jianli, et al.
Publicado: (2014)

The critical role of S-lactoylglutathione formation during methylglyoxal detoxification in Escherichia coli
por: Ozyamak, Ertan, et al.
Publicado: (2010)

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) co-produced with l-isoleucine in Corynebacterium glutamicum WM001
por: Ma, Wenjian, et al.
Publicado: (2018)

Metabolic engineering of Escherichia coli for efficient biosynthesis of butyl acetate
por: Ku, Jason T., et al.
Publicado: (2022)

Control and regulation of acetate overflow in Escherichia coli
por: Millard, Pierre, et al.
Publicado: (2021)

Genetically Engineering Escherichia coli to Produce Xylitol from Corncob Hydrolysate without Lime Detoxification
por: Yuan, Xinsong, et al.
Publicado: (2023)

Metabolic engineering of Escherichia coli for poly(3-hydroxybutyrate) production via threonine bypass
por: Lin, Zhenquan, et al.
Publicado: (2015)

Discharging tRNAs: a tug of war between translation and detoxification in Escherichia coli
por: Avcilar-Kucukgoze, Irem, et al.
Publicado: (2016)

Effect of RecA inactivation and detoxification systems on the evolution of ciprofloxacin resistance in Escherichia coli
por: Diaz-Diaz, S, et al.
Publicado: (2021)

Activating Silent Glycolysis Bypasses in Escherichia coli
por: Iacometti, Camillo, et al.
Publicado: (2022)

Anaerobic detoxification of acetic acid in a thermophilic ethanologen
por: Shaw, A Joe, et al.
Publicado: (2015)

Aflatoxin B(1) Degradation and Detoxification by Escherichia coli CG1061 Isolated From Chicken Cecum
por: Wang, Lingling, et al.
Publicado: (2019)

Co-production of hydrogen and ethyl acetate in Escherichia coli
por: Bohnenkamp, Anna C., et al.
Publicado: (2021)

Extracellular expression of glutamate decarboxylase B in Escherichia coli to improve gamma-aminobutyric acid production
por: Zhao, Anqi, et al.
Publicado: (2016)

Eliminating acetate formation improves citramalate production by metabolically engineered Escherichia coli
por: Parimi, Naga Sirisha, et al.
Publicado: (2017)

4-(2-Butyl-6,7-dichloro-2-cyclopentyl-indan-1-on-5-yl) oxobutyric acid inhibits angiogenesis via modulation of vascular endothelial growth factor receptor 2 signaling pathway
por: Zhou, Tianli, et al.
Publicado: (2022)

α-Ketoglutarate Accumulation Is Not Dependent on Isocitrate Dehydrogenase Activity during Tellurite Detoxification in Escherichia coli
por: Reinoso, Claudia A., et al.
Publicado: (2013)

Escherichia coli Remodels the Chemotaxis Pathway for Swarming
por: Partridge, Jonathan D., et al.
Publicado: (2019)

Metabolic engineering of Escherichia coli for the synthesis of polyhydroxyalkanoates using acetate as a main carbon source
por: Chen, Jing, et al.
Publicado: (2018)

Physiological and Molecular Timing of the Glucose to Acetate Transition in Escherichia coli
por: Enjalbert, Brice, et al.
Publicado: (2013)

Engineering Escherichia coli to convert acetic acid to β-caryophyllene
por: Yang, Jianming, et al.
Publicado: (2016)

Acetate metabolic requirement of avian pathogenic Escherichia coli promotes its intracellular proliferation within macrophage
por: Zhuge, Xiangkai, et al.
Publicado: (2019)

Expression regulation of multiple key genes to improve l-threonine in Escherichia coli
por: Zhao, Lei, et al.
Publicado: (2020)

Protein acetylation affects acetate metabolism, motility and acid stress response in Escherichia coli
por: Castaño-Cerezo, Sara, et al.
Publicado: (2014)

Multilevel optimisation of anaerobic ethyl acetate production in engineered Escherichia coli
por: Bohnenkamp, Anna C., et al.
Publicado: (2020)

Synthesis of isobutanol using acetate as sole carbon source in Escherichia coli
por: Gu, Pengfei, et al.
Publicado: (2023)

The Multidrug Efflux Regulator AcrR of Escherichia coli Responds to Exogenous and Endogenous Ligands To Regulate Efflux and Detoxification
por: Harmon, Dana E., et al.
Publicado: (2022)

Use of Acetic Acid to Partially Replace Lactic Acid for Decontamination against Escherichia coli O157:H7 in Fresh Produce and Mechanism of Action
por: Wang, Jiayi, et al.
Publicado: (2021)

Metabolic Engineering of Shikimic Acid Biosynthesis Pathway for the Production of Shikimic Acid and Its Branched Products in Microorganisms: Advances and Prospects
por: Wu, Sijia, et al.
Publicado: (2022)

Construction of an Escherichia coli Strain Lacking Fimbriae by Deleting 64 Genes and Its Application for Efficient Production of Poly(3-Hydroxybutyrate) and l-Threonine
por: Qiao, Jun, et al.
Publicado: (2021)

Metabolic Engineering of Microorganisms to Produce Pyruvate and Derived Compounds
por: Luo, Qian, et al.
Publicado: (2023)

Lateral Acquisitions Repeatedly Remodel the Oxygen Detoxification Pathway in Diplomonads and Relatives
por: Jiménez-González, Alejandro, et al.
Publicado: (2019)

Improving Acetate Tolerance of Escherichia coli by Rewiring Its Global Regulator cAMP Receptor Protein (CRP)
por: Chong, Huiqing, et al.
Publicado: (2013)

An insight into the role of phosphotransacetylase (pta) and the acetate/acetyl-CoA node in Escherichia coli
por: Castaño-Cerezo, Sara, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_aflamnn1l87vb91ddhrvmqnqbl