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Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas

Background and objectives: The histological classification and staging of thymic tumors remains a matter of debate. The correlation of computed tomography (CT) parameters with tumor histology and stage also still has to be completely assessed. The aim of this study was therefore to analyze the corre...

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Autores principales: Carretta, Angelo, Viscardi, Stefano, Muriana, Piergiorgio, Ciriaco, Paola, Bandiera, Alessandro, Varagona, Roberto, Colombo, Michele, Negri, Giampiero
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824084/
https://www.ncbi.nlm.nih.gov/pubmed/33374432
http://dx.doi.org/10.3390/medicina57010010
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author Carretta, Angelo
Viscardi, Stefano
Muriana, Piergiorgio
Ciriaco, Paola
Bandiera, Alessandro
Varagona, Roberto
Colombo, Michele
Negri, Giampiero
author_facet Carretta, Angelo
Viscardi, Stefano
Muriana, Piergiorgio
Ciriaco, Paola
Bandiera, Alessandro
Varagona, Roberto
Colombo, Michele
Negri, Giampiero
author_sort Carretta, Angelo
collection PubMed
description Background and objectives: The histological classification and staging of thymic tumors remains a matter of debate. The correlation of computed tomography (CT) parameters with tumor histology and stage also still has to be completely assessed. The aim of this study was therefore to analyze the correlation of radiological parameters with histological and staging classifications of thymomas evaluating their prognostic role. Materials and Methods: Data of 50 patients with thymoma submitted to a complete surgical treatment between 2005 and 2015 were retrospectively analyzed. Tumors were classified according to the WHO and Suster and Moran (S&M) histological classifications and to the Masaoka–Koga and tumor, node and metastases (TNM) staging systems. The correlation of CT features with histology and stage and the prognostic role of histopathological and radiological features were assessed. Results: Five-year overall (OS) and disease-free survival (DFS) were 90.3% and 81.1%, respectively. A significant correlation of DFS with the Masaoka–Koga (p = 0.001) and TNM staging systems (p = 0.002) and with the S&M (p = 0.02) and WHO histological classifications (p = 0.04) was observed. CT scan features correlated with tumor stage, histology and prognosis. Moderately differentiated tumors (WHO B3) had a significantly higher incidence of irregular shape and contours (p = 0.002 and p = 0.001, respectively) and pericardial contact (p = 0.036). A larger tumor volume (p = 0.03) and a greater length of pleural contact (p = 0.04) adversely influenced DFS. The presence of pleural (p < 0.001) or lung invasion (p = 0.02) and of pleural effusion (p = 0.004) was associated with a significantly worse OS. Conclusions: Pre-operative CT scan parameters correlate with stage and histology, and have a prognostic role in surgically treated thymomas.
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spelling pubmed-78240842021-01-24 Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas Carretta, Angelo Viscardi, Stefano Muriana, Piergiorgio Ciriaco, Paola Bandiera, Alessandro Varagona, Roberto Colombo, Michele Negri, Giampiero Medicina (Kaunas) Article Background and objectives: The histological classification and staging of thymic tumors remains a matter of debate. The correlation of computed tomography (CT) parameters with tumor histology and stage also still has to be completely assessed. The aim of this study was therefore to analyze the correlation of radiological parameters with histological and staging classifications of thymomas evaluating their prognostic role. Materials and Methods: Data of 50 patients with thymoma submitted to a complete surgical treatment between 2005 and 2015 were retrospectively analyzed. Tumors were classified according to the WHO and Suster and Moran (S&M) histological classifications and to the Masaoka–Koga and tumor, node and metastases (TNM) staging systems. The correlation of CT features with histology and stage and the prognostic role of histopathological and radiological features were assessed. Results: Five-year overall (OS) and disease-free survival (DFS) were 90.3% and 81.1%, respectively. A significant correlation of DFS with the Masaoka–Koga (p = 0.001) and TNM staging systems (p = 0.002) and with the S&M (p = 0.02) and WHO histological classifications (p = 0.04) was observed. CT scan features correlated with tumor stage, histology and prognosis. Moderately differentiated tumors (WHO B3) had a significantly higher incidence of irregular shape and contours (p = 0.002 and p = 0.001, respectively) and pericardial contact (p = 0.036). A larger tumor volume (p = 0.03) and a greater length of pleural contact (p = 0.04) adversely influenced DFS. The presence of pleural (p < 0.001) or lung invasion (p = 0.02) and of pleural effusion (p = 0.004) was associated with a significantly worse OS. Conclusions: Pre-operative CT scan parameters correlate with stage and histology, and have a prognostic role in surgically treated thymomas. MDPI 2020-12-24 /pmc/articles/PMC7824084/ /pubmed/33374432 http://dx.doi.org/10.3390/medicina57010010 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Carretta, Angelo
Viscardi, Stefano
Muriana, Piergiorgio
Ciriaco, Paola
Bandiera, Alessandro
Varagona, Roberto
Colombo, Michele
Negri, Giampiero
Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas
title Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas
title_full Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas
title_fullStr Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas
title_full_unstemmed Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas
title_short Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas
title_sort correlation of computed tomography parameters with histology, stage and prognosis in surgically treated thymomas
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824084/
https://www.ncbi.nlm.nih.gov/pubmed/33374432
http://dx.doi.org/10.3390/medicina57010010
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