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Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas
Background and objectives: The histological classification and staging of thymic tumors remains a matter of debate. The correlation of computed tomography (CT) parameters with tumor histology and stage also still has to be completely assessed. The aim of this study was therefore to analyze the corre...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824084/ https://www.ncbi.nlm.nih.gov/pubmed/33374432 http://dx.doi.org/10.3390/medicina57010010 |
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author | Carretta, Angelo Viscardi, Stefano Muriana, Piergiorgio Ciriaco, Paola Bandiera, Alessandro Varagona, Roberto Colombo, Michele Negri, Giampiero |
author_facet | Carretta, Angelo Viscardi, Stefano Muriana, Piergiorgio Ciriaco, Paola Bandiera, Alessandro Varagona, Roberto Colombo, Michele Negri, Giampiero |
author_sort | Carretta, Angelo |
collection | PubMed |
description | Background and objectives: The histological classification and staging of thymic tumors remains a matter of debate. The correlation of computed tomography (CT) parameters with tumor histology and stage also still has to be completely assessed. The aim of this study was therefore to analyze the correlation of radiological parameters with histological and staging classifications of thymomas evaluating their prognostic role. Materials and Methods: Data of 50 patients with thymoma submitted to a complete surgical treatment between 2005 and 2015 were retrospectively analyzed. Tumors were classified according to the WHO and Suster and Moran (S&M) histological classifications and to the Masaoka–Koga and tumor, node and metastases (TNM) staging systems. The correlation of CT features with histology and stage and the prognostic role of histopathological and radiological features were assessed. Results: Five-year overall (OS) and disease-free survival (DFS) were 90.3% and 81.1%, respectively. A significant correlation of DFS with the Masaoka–Koga (p = 0.001) and TNM staging systems (p = 0.002) and with the S&M (p = 0.02) and WHO histological classifications (p = 0.04) was observed. CT scan features correlated with tumor stage, histology and prognosis. Moderately differentiated tumors (WHO B3) had a significantly higher incidence of irregular shape and contours (p = 0.002 and p = 0.001, respectively) and pericardial contact (p = 0.036). A larger tumor volume (p = 0.03) and a greater length of pleural contact (p = 0.04) adversely influenced DFS. The presence of pleural (p < 0.001) or lung invasion (p = 0.02) and of pleural effusion (p = 0.004) was associated with a significantly worse OS. Conclusions: Pre-operative CT scan parameters correlate with stage and histology, and have a prognostic role in surgically treated thymomas. |
format | Online Article Text |
id | pubmed-7824084 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78240842021-01-24 Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas Carretta, Angelo Viscardi, Stefano Muriana, Piergiorgio Ciriaco, Paola Bandiera, Alessandro Varagona, Roberto Colombo, Michele Negri, Giampiero Medicina (Kaunas) Article Background and objectives: The histological classification and staging of thymic tumors remains a matter of debate. The correlation of computed tomography (CT) parameters with tumor histology and stage also still has to be completely assessed. The aim of this study was therefore to analyze the correlation of radiological parameters with histological and staging classifications of thymomas evaluating their prognostic role. Materials and Methods: Data of 50 patients with thymoma submitted to a complete surgical treatment between 2005 and 2015 were retrospectively analyzed. Tumors were classified according to the WHO and Suster and Moran (S&M) histological classifications and to the Masaoka–Koga and tumor, node and metastases (TNM) staging systems. The correlation of CT features with histology and stage and the prognostic role of histopathological and radiological features were assessed. Results: Five-year overall (OS) and disease-free survival (DFS) were 90.3% and 81.1%, respectively. A significant correlation of DFS with the Masaoka–Koga (p = 0.001) and TNM staging systems (p = 0.002) and with the S&M (p = 0.02) and WHO histological classifications (p = 0.04) was observed. CT scan features correlated with tumor stage, histology and prognosis. Moderately differentiated tumors (WHO B3) had a significantly higher incidence of irregular shape and contours (p = 0.002 and p = 0.001, respectively) and pericardial contact (p = 0.036). A larger tumor volume (p = 0.03) and a greater length of pleural contact (p = 0.04) adversely influenced DFS. The presence of pleural (p < 0.001) or lung invasion (p = 0.02) and of pleural effusion (p = 0.004) was associated with a significantly worse OS. Conclusions: Pre-operative CT scan parameters correlate with stage and histology, and have a prognostic role in surgically treated thymomas. MDPI 2020-12-24 /pmc/articles/PMC7824084/ /pubmed/33374432 http://dx.doi.org/10.3390/medicina57010010 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Carretta, Angelo Viscardi, Stefano Muriana, Piergiorgio Ciriaco, Paola Bandiera, Alessandro Varagona, Roberto Colombo, Michele Negri, Giampiero Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas |
title | Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas |
title_full | Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas |
title_fullStr | Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas |
title_full_unstemmed | Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas |
title_short | Correlation of Computed Tomography Parameters with Histology, Stage and Prognosis in Surgically Treated Thymomas |
title_sort | correlation of computed tomography parameters with histology, stage and prognosis in surgically treated thymomas |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824084/ https://www.ncbi.nlm.nih.gov/pubmed/33374432 http://dx.doi.org/10.3390/medicina57010010 |
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