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Brain Disorders and Chemical Pollutants: A Gap Junction Link? (†)

The incidence of brain pathologies has increased during last decades. Better diagnosis (autism spectrum disorders) and longer life expectancy (Parkinson’s disease, Alzheimer’s disease) partly explain this increase, while emerging data suggest pollutant exposures as a possible but still underestimate...

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Detalles Bibliográficos
Autores principales: Mesnil, Marc, Defamie, Norah, Naus, Christian, Sarrouilhe, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824109/
https://www.ncbi.nlm.nih.gov/pubmed/33396565
http://dx.doi.org/10.3390/biom11010051
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author Mesnil, Marc
Defamie, Norah
Naus, Christian
Sarrouilhe, Denis
author_facet Mesnil, Marc
Defamie, Norah
Naus, Christian
Sarrouilhe, Denis
author_sort Mesnil, Marc
collection PubMed
description The incidence of brain pathologies has increased during last decades. Better diagnosis (autism spectrum disorders) and longer life expectancy (Parkinson’s disease, Alzheimer’s disease) partly explain this increase, while emerging data suggest pollutant exposures as a possible but still underestimated cause of major brain disorders. Taking into account that the brain parenchyma is rich in gap junctions and that most pollutants inhibit their function; brain disorders might be the consequence of gap-junctional alterations due to long-term exposures to pollutants. In this article, this hypothesis is addressed through three complementary aspects: (1) the gap-junctional organization and connexin expression in brain parenchyma and their function; (2) the effect of major pollutants (pesticides, bisphenol A, phthalates, heavy metals, airborne particles, etc.) on gap-junctional and connexin functions; (3) a description of the major brain disorders categorized as neurodevelopmental (autism spectrum disorders, attention deficit hyperactivity disorders, epilepsy), neurobehavioral (migraines, major depressive disorders), neurodegenerative (Parkinson’s and Alzheimer’s diseases) and cancers (glioma), in which both connexin dysfunction and pollutant involvement have been described. Based on these different aspects, the possible involvement of pollutant-inhibited gap junctions in brain disorders is discussed for prenatal and postnatal exposures.
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spelling pubmed-78241092021-01-24 Brain Disorders and Chemical Pollutants: A Gap Junction Link? (†) Mesnil, Marc Defamie, Norah Naus, Christian Sarrouilhe, Denis Biomolecules Review The incidence of brain pathologies has increased during last decades. Better diagnosis (autism spectrum disorders) and longer life expectancy (Parkinson’s disease, Alzheimer’s disease) partly explain this increase, while emerging data suggest pollutant exposures as a possible but still underestimated cause of major brain disorders. Taking into account that the brain parenchyma is rich in gap junctions and that most pollutants inhibit their function; brain disorders might be the consequence of gap-junctional alterations due to long-term exposures to pollutants. In this article, this hypothesis is addressed through three complementary aspects: (1) the gap-junctional organization and connexin expression in brain parenchyma and their function; (2) the effect of major pollutants (pesticides, bisphenol A, phthalates, heavy metals, airborne particles, etc.) on gap-junctional and connexin functions; (3) a description of the major brain disorders categorized as neurodevelopmental (autism spectrum disorders, attention deficit hyperactivity disorders, epilepsy), neurobehavioral (migraines, major depressive disorders), neurodegenerative (Parkinson’s and Alzheimer’s diseases) and cancers (glioma), in which both connexin dysfunction and pollutant involvement have been described. Based on these different aspects, the possible involvement of pollutant-inhibited gap junctions in brain disorders is discussed for prenatal and postnatal exposures. MDPI 2020-12-31 /pmc/articles/PMC7824109/ /pubmed/33396565 http://dx.doi.org/10.3390/biom11010051 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mesnil, Marc
Defamie, Norah
Naus, Christian
Sarrouilhe, Denis
Brain Disorders and Chemical Pollutants: A Gap Junction Link? (†)
title Brain Disorders and Chemical Pollutants: A Gap Junction Link? (†)
title_full Brain Disorders and Chemical Pollutants: A Gap Junction Link? (†)
title_fullStr Brain Disorders and Chemical Pollutants: A Gap Junction Link? (†)
title_full_unstemmed Brain Disorders and Chemical Pollutants: A Gap Junction Link? (†)
title_short Brain Disorders and Chemical Pollutants: A Gap Junction Link? (†)
title_sort brain disorders and chemical pollutants: a gap junction link? (†)
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824109/
https://www.ncbi.nlm.nih.gov/pubmed/33396565
http://dx.doi.org/10.3390/biom11010051
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