Cargando…

Hypodiploid B-Lymphoblastic Leukemia Presenting as an Isolated Orbital Mass Prior to Systemic Involvement: A Case Report and Review of the Literature

We describe a 4-year-old boy who presented with progressive right periorbital edema and proptosis, with no systemic symptoms, who was found to have B-lymphoblastic leukemia (B-ALL). Magnetic resonance imaging (MRI) showed an enhancing mass centered in the right superolateral extraconal orbit. Orbita...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Linyan, Ashraf, Davin C., Kinde, Benyam, Ohgami, Robert S., Kumar, Jyoti, Kersten, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824143/
https://www.ncbi.nlm.nih.gov/pubmed/33375646
http://dx.doi.org/10.3390/diagnostics11010025
_version_ 1783640004863459328
author Wang, Linyan
Ashraf, Davin C.
Kinde, Benyam
Ohgami, Robert S.
Kumar, Jyoti
Kersten, Robert C.
author_facet Wang, Linyan
Ashraf, Davin C.
Kinde, Benyam
Ohgami, Robert S.
Kumar, Jyoti
Kersten, Robert C.
author_sort Wang, Linyan
collection PubMed
description We describe a 4-year-old boy who presented with progressive right periorbital edema and proptosis, with no systemic symptoms, who was found to have B-lymphoblastic leukemia (B-ALL). Magnetic resonance imaging (MRI) showed an enhancing mass centered in the right superolateral extraconal orbit. Orbital biopsy was consistent with B-ALL (CD99, TdT, LCA cocktail, CD34, CD79, CD10, PAX5, MIB1 positive; CD3, CD20 negative). A subsequent bone marrow aspirate confirmed a diagnosis of B-ALL with 80% blasts by flow cytometry and haploid cytogenetic findings. The patient improved clinically after chemotherapy. There are seven cases previously reported in the literature with hematogenous orbital masses at initial presentation of childhood ALL, but all with systemic symptoms or an abnormal complete blood count (CBC) at presentation. Our case is the first report in which an orbital mass preceded detectable systemic or laboratory evidence of ALL. This patient highlights the importance of differentiating benign causes of eyelid swelling from malignant ones.
format Online
Article
Text
id pubmed-7824143
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-78241432021-01-24 Hypodiploid B-Lymphoblastic Leukemia Presenting as an Isolated Orbital Mass Prior to Systemic Involvement: A Case Report and Review of the Literature Wang, Linyan Ashraf, Davin C. Kinde, Benyam Ohgami, Robert S. Kumar, Jyoti Kersten, Robert C. Diagnostics (Basel) Case Report We describe a 4-year-old boy who presented with progressive right periorbital edema and proptosis, with no systemic symptoms, who was found to have B-lymphoblastic leukemia (B-ALL). Magnetic resonance imaging (MRI) showed an enhancing mass centered in the right superolateral extraconal orbit. Orbital biopsy was consistent with B-ALL (CD99, TdT, LCA cocktail, CD34, CD79, CD10, PAX5, MIB1 positive; CD3, CD20 negative). A subsequent bone marrow aspirate confirmed a diagnosis of B-ALL with 80% blasts by flow cytometry and haploid cytogenetic findings. The patient improved clinically after chemotherapy. There are seven cases previously reported in the literature with hematogenous orbital masses at initial presentation of childhood ALL, but all with systemic symptoms or an abnormal complete blood count (CBC) at presentation. Our case is the first report in which an orbital mass preceded detectable systemic or laboratory evidence of ALL. This patient highlights the importance of differentiating benign causes of eyelid swelling from malignant ones. MDPI 2020-12-25 /pmc/articles/PMC7824143/ /pubmed/33375646 http://dx.doi.org/10.3390/diagnostics11010025 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Wang, Linyan
Ashraf, Davin C.
Kinde, Benyam
Ohgami, Robert S.
Kumar, Jyoti
Kersten, Robert C.
Hypodiploid B-Lymphoblastic Leukemia Presenting as an Isolated Orbital Mass Prior to Systemic Involvement: A Case Report and Review of the Literature
title Hypodiploid B-Lymphoblastic Leukemia Presenting as an Isolated Orbital Mass Prior to Systemic Involvement: A Case Report and Review of the Literature
title_full Hypodiploid B-Lymphoblastic Leukemia Presenting as an Isolated Orbital Mass Prior to Systemic Involvement: A Case Report and Review of the Literature
title_fullStr Hypodiploid B-Lymphoblastic Leukemia Presenting as an Isolated Orbital Mass Prior to Systemic Involvement: A Case Report and Review of the Literature
title_full_unstemmed Hypodiploid B-Lymphoblastic Leukemia Presenting as an Isolated Orbital Mass Prior to Systemic Involvement: A Case Report and Review of the Literature
title_short Hypodiploid B-Lymphoblastic Leukemia Presenting as an Isolated Orbital Mass Prior to Systemic Involvement: A Case Report and Review of the Literature
title_sort hypodiploid b-lymphoblastic leukemia presenting as an isolated orbital mass prior to systemic involvement: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824143/
https://www.ncbi.nlm.nih.gov/pubmed/33375646
http://dx.doi.org/10.3390/diagnostics11010025
work_keys_str_mv AT wanglinyan hypodiploidblymphoblasticleukemiapresentingasanisolatedorbitalmasspriortosystemicinvolvementacasereportandreviewoftheliterature
AT ashrafdavinc hypodiploidblymphoblasticleukemiapresentingasanisolatedorbitalmasspriortosystemicinvolvementacasereportandreviewoftheliterature
AT kindebenyam hypodiploidblymphoblasticleukemiapresentingasanisolatedorbitalmasspriortosystemicinvolvementacasereportandreviewoftheliterature
AT ohgamiroberts hypodiploidblymphoblasticleukemiapresentingasanisolatedorbitalmasspriortosystemicinvolvementacasereportandreviewoftheliterature
AT kumarjyoti hypodiploidblymphoblasticleukemiapresentingasanisolatedorbitalmasspriortosystemicinvolvementacasereportandreviewoftheliterature
AT kerstenrobertc hypodiploidblymphoblasticleukemiapresentingasanisolatedorbitalmasspriortosystemicinvolvementacasereportandreviewoftheliterature