Bioactive Bis(indole) Alkaloids from a Spongosorites sp. Sponge

Six new bis(indole) alkaloids (1–6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A–D (1–4) were determined to possess a 2-methoxy-1-imidazole-5-one...

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Detalles Bibliográficos
Autores principales: Park, Jae Sung, Cho, Eunji, Hwang, Ji-Yeon, Park, Sung Chul, Chung, Beomkoo, Kwon, Oh-Seok, Sim, Chung J., Oh, Dong-Chan, Oh, Ki-Bong, Shin, Jongheon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824209/
https://www.ncbi.nlm.nih.gov/pubmed/33374750
http://dx.doi.org/10.3390/md19010003
Descripción
Sumario:Six new bis(indole) alkaloids (1–6) along with eight known ones of the topsentin class were isolated from a Spongosorites sp. sponge of Korea. Based on the results of combined spectroscopic analyses, the structures of spongosoritins A–D (1–4) were determined to possess a 2-methoxy-1-imidazole-5-one core connecting the indole moieties, and these were linked by a linear urea bridge for spongocarbamides A (5) and B (6). The absolute configurations of spongosoritins were assigned by electronic circular dichroism (ECD) computation. The new compounds exhibited moderate inhibition against transpeptidase sortase A and weak inhibition against human pathogenic bacteria and A549 and K562 cancer cell lines.

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