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Visceral Adiposity, Pro-Inflammatory Signaling and Vasculopathy in Metabolically Unhealthy Non-Obesity Phenotype

The debate regarding the actual cardiovascular burden in metabolically healthy obese or metabolically unhealthy non-obesity individuals is ongoing. Accumulating data have suggested a unique pathophysiological role of pro-inflammatory cytokines in mediating metabolic and cardiovascular disorders by d...

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Autores principales: Tsou, Meng-Ting, Yun, Chun-Ho, Lin, Jiun-Lu, Sung, Kuo-Tzu, Tsai, Jui-Peng, Huang, Wen-Hung, Liu, Chia-Yuan, Hou, Charles Jia-Yin, Tsai, I.-Hsien, Su, Cheng-Huang, Hung, Chung-Lieh, Hung, Ta-Chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824214/
https://www.ncbi.nlm.nih.gov/pubmed/33383705
http://dx.doi.org/10.3390/diagnostics11010040
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author Tsou, Meng-Ting
Yun, Chun-Ho
Lin, Jiun-Lu
Sung, Kuo-Tzu
Tsai, Jui-Peng
Huang, Wen-Hung
Liu, Chia-Yuan
Hou, Charles Jia-Yin
Tsai, I.-Hsien
Su, Cheng-Huang
Hung, Chung-Lieh
Hung, Ta-Chuan
author_facet Tsou, Meng-Ting
Yun, Chun-Ho
Lin, Jiun-Lu
Sung, Kuo-Tzu
Tsai, Jui-Peng
Huang, Wen-Hung
Liu, Chia-Yuan
Hou, Charles Jia-Yin
Tsai, I.-Hsien
Su, Cheng-Huang
Hung, Chung-Lieh
Hung, Ta-Chuan
author_sort Tsou, Meng-Ting
collection PubMed
description The debate regarding the actual cardiovascular burden in metabolically healthy obese or metabolically unhealthy non-obesity individuals is ongoing. Accumulating data have suggested a unique pathophysiological role of pro-inflammatory cytokines in mediating metabolic and cardiovascular disorders by dysregulated visceral adiposity. To compare the burden of visceral adiposity, the inflammatory marker high-sensitivity C-reactive protein (hs-CRP) and the prevalent atherosclerotic burden in metabolically healthy obese (MHO) or metabolically unhealthy (MU) populations, were compared to those of metabolically healthy non-obesity subjects (MHNO). Coronary artery calcification score (CACS) and visceral fat, including pericardial fat (PCF)/thoracic peri-aortic fat (TAT), were quantified in 2846 asymptomatic subjects using a CT dataset. A cross-sectional analysis comparing CACS, inflammatory marker hs-CRP, and visceral fat burden among four obesity phenotypes (MHNO, metabolically unhealthy non-obesity (MUNO), MHO, and metabolically unhealthy obese (MUO)) was performed. Both MUNO and MUO demonstrated significantly higher hs-CRP and greater CACS than MHNO/MHO (adjusted coefficient: 25.46, 95% confidence interval (CI): 5.29–45.63; 43.55, 95% CI: 23.38–63.73 for MUNO and MUO (MHNO as reference); both p < 0.05). Visceral fat (PCF/TAT) was an independent determinant of MU and was similarly higher in the MUNO/MHO groups than in the MHNO group, with the MUO group having the largest amount. PCF/TAT, obesity, and MU remained significantly associated with higher CACS even after adjustment, with larger PCF/TAT modified effects for MU and diabetes in CACS (both p(interaction) < 0.05). MU tightly linked to excessive visceral adiposity was a strong and independent risk factor for coronary atherosclerosis even in lean individuals, which could be partially explained by its coalignment with pathological pro-inflammatory signaling.
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spelling pubmed-78242142021-01-24 Visceral Adiposity, Pro-Inflammatory Signaling and Vasculopathy in Metabolically Unhealthy Non-Obesity Phenotype Tsou, Meng-Ting Yun, Chun-Ho Lin, Jiun-Lu Sung, Kuo-Tzu Tsai, Jui-Peng Huang, Wen-Hung Liu, Chia-Yuan Hou, Charles Jia-Yin Tsai, I.-Hsien Su, Cheng-Huang Hung, Chung-Lieh Hung, Ta-Chuan Diagnostics (Basel) Article The debate regarding the actual cardiovascular burden in metabolically healthy obese or metabolically unhealthy non-obesity individuals is ongoing. Accumulating data have suggested a unique pathophysiological role of pro-inflammatory cytokines in mediating metabolic and cardiovascular disorders by dysregulated visceral adiposity. To compare the burden of visceral adiposity, the inflammatory marker high-sensitivity C-reactive protein (hs-CRP) and the prevalent atherosclerotic burden in metabolically healthy obese (MHO) or metabolically unhealthy (MU) populations, were compared to those of metabolically healthy non-obesity subjects (MHNO). Coronary artery calcification score (CACS) and visceral fat, including pericardial fat (PCF)/thoracic peri-aortic fat (TAT), were quantified in 2846 asymptomatic subjects using a CT dataset. A cross-sectional analysis comparing CACS, inflammatory marker hs-CRP, and visceral fat burden among four obesity phenotypes (MHNO, metabolically unhealthy non-obesity (MUNO), MHO, and metabolically unhealthy obese (MUO)) was performed. Both MUNO and MUO demonstrated significantly higher hs-CRP and greater CACS than MHNO/MHO (adjusted coefficient: 25.46, 95% confidence interval (CI): 5.29–45.63; 43.55, 95% CI: 23.38–63.73 for MUNO and MUO (MHNO as reference); both p < 0.05). Visceral fat (PCF/TAT) was an independent determinant of MU and was similarly higher in the MUNO/MHO groups than in the MHNO group, with the MUO group having the largest amount. PCF/TAT, obesity, and MU remained significantly associated with higher CACS even after adjustment, with larger PCF/TAT modified effects for MU and diabetes in CACS (both p(interaction) < 0.05). MU tightly linked to excessive visceral adiposity was a strong and independent risk factor for coronary atherosclerosis even in lean individuals, which could be partially explained by its coalignment with pathological pro-inflammatory signaling. MDPI 2020-12-29 /pmc/articles/PMC7824214/ /pubmed/33383705 http://dx.doi.org/10.3390/diagnostics11010040 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tsou, Meng-Ting
Yun, Chun-Ho
Lin, Jiun-Lu
Sung, Kuo-Tzu
Tsai, Jui-Peng
Huang, Wen-Hung
Liu, Chia-Yuan
Hou, Charles Jia-Yin
Tsai, I.-Hsien
Su, Cheng-Huang
Hung, Chung-Lieh
Hung, Ta-Chuan
Visceral Adiposity, Pro-Inflammatory Signaling and Vasculopathy in Metabolically Unhealthy Non-Obesity Phenotype
title Visceral Adiposity, Pro-Inflammatory Signaling and Vasculopathy in Metabolically Unhealthy Non-Obesity Phenotype
title_full Visceral Adiposity, Pro-Inflammatory Signaling and Vasculopathy in Metabolically Unhealthy Non-Obesity Phenotype
title_fullStr Visceral Adiposity, Pro-Inflammatory Signaling and Vasculopathy in Metabolically Unhealthy Non-Obesity Phenotype
title_full_unstemmed Visceral Adiposity, Pro-Inflammatory Signaling and Vasculopathy in Metabolically Unhealthy Non-Obesity Phenotype
title_short Visceral Adiposity, Pro-Inflammatory Signaling and Vasculopathy in Metabolically Unhealthy Non-Obesity Phenotype
title_sort visceral adiposity, pro-inflammatory signaling and vasculopathy in metabolically unhealthy non-obesity phenotype
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824214/
https://www.ncbi.nlm.nih.gov/pubmed/33383705
http://dx.doi.org/10.3390/diagnostics11010040
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