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Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters

Multifunctional imaging nanoprobes continue to garner strong interest for their great potential in the detection and monitoring of cancer. In this study, we investigate a series of spatially arranged iron oxide nanocube-based clusters (i.e., chain-like dimer/trimer, centrosymmetric clusters, and enz...

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Autores principales: Avugadda, Sahitya Kumar, Wickramasinghe, Sameera, Niculaes, Dina, Ju, Minseon, Lak, Aidin, Silvestri, Niccolò, Nitti, Simone, Roy, Ipsita, Samia, Anna Cristina S., Pellegrino, Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824301/
https://www.ncbi.nlm.nih.gov/pubmed/33383768
http://dx.doi.org/10.3390/nano11010062
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author Avugadda, Sahitya Kumar
Wickramasinghe, Sameera
Niculaes, Dina
Ju, Minseon
Lak, Aidin
Silvestri, Niccolò
Nitti, Simone
Roy, Ipsita
Samia, Anna Cristina S.
Pellegrino, Teresa
author_facet Avugadda, Sahitya Kumar
Wickramasinghe, Sameera
Niculaes, Dina
Ju, Minseon
Lak, Aidin
Silvestri, Niccolò
Nitti, Simone
Roy, Ipsita
Samia, Anna Cristina S.
Pellegrino, Teresa
author_sort Avugadda, Sahitya Kumar
collection PubMed
description Multifunctional imaging nanoprobes continue to garner strong interest for their great potential in the detection and monitoring of cancer. In this study, we investigate a series of spatially arranged iron oxide nanocube-based clusters (i.e., chain-like dimer/trimer, centrosymmetric clusters, and enzymatically cleavable two-dimensional clusters) as magnetic particle imaging and magnetic resonance imaging probes. Our findings demonstrate that the short nanocube chain assemblies exhibit remarkable magnetic particle imaging signal enhancement with respect to the individually dispersed or the centrosymmetric cluster analogues. This result can be attributed to the beneficial uniaxial magnetic dipolar coupling occurring in the chain-like nanocube assembly. Moreover, we could effectively synthesize enzymatically cleavable two-dimensional nanocube clusters, which upon exposure to a lytic enzyme, exhibit a progressive increase in magnetic particle imaging signal at well-defined incubation time points. The increase in magnetic particle imaging signal can be used to trace the disassembly of the large planar clusters into smaller nanocube chains by enzymatic polymer degradation. These studies demonstrate that chain-like assemblies of iron oxide nanocubes offer the best spatial arrangement to improve magnetic particle imaging signals. In addition, the nanocube clusters synthesized in this study also show remarkable transverse magnetic resonance imaging relaxation signals. These nanoprobes, previously showcased for their outstanding heat performance in magnetic hyperthermia applications, have great potential as dual imaging probes and could be employed to improve the tumor thermo-therapeutic efficacy, while offering a readable magnetic signal for image mapping of material disassemblies at tumor sites.
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spelling pubmed-78243012021-01-24 Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters Avugadda, Sahitya Kumar Wickramasinghe, Sameera Niculaes, Dina Ju, Minseon Lak, Aidin Silvestri, Niccolò Nitti, Simone Roy, Ipsita Samia, Anna Cristina S. Pellegrino, Teresa Nanomaterials (Basel) Communication Multifunctional imaging nanoprobes continue to garner strong interest for their great potential in the detection and monitoring of cancer. In this study, we investigate a series of spatially arranged iron oxide nanocube-based clusters (i.e., chain-like dimer/trimer, centrosymmetric clusters, and enzymatically cleavable two-dimensional clusters) as magnetic particle imaging and magnetic resonance imaging probes. Our findings demonstrate that the short nanocube chain assemblies exhibit remarkable magnetic particle imaging signal enhancement with respect to the individually dispersed or the centrosymmetric cluster analogues. This result can be attributed to the beneficial uniaxial magnetic dipolar coupling occurring in the chain-like nanocube assembly. Moreover, we could effectively synthesize enzymatically cleavable two-dimensional nanocube clusters, which upon exposure to a lytic enzyme, exhibit a progressive increase in magnetic particle imaging signal at well-defined incubation time points. The increase in magnetic particle imaging signal can be used to trace the disassembly of the large planar clusters into smaller nanocube chains by enzymatic polymer degradation. These studies demonstrate that chain-like assemblies of iron oxide nanocubes offer the best spatial arrangement to improve magnetic particle imaging signals. In addition, the nanocube clusters synthesized in this study also show remarkable transverse magnetic resonance imaging relaxation signals. These nanoprobes, previously showcased for their outstanding heat performance in magnetic hyperthermia applications, have great potential as dual imaging probes and could be employed to improve the tumor thermo-therapeutic efficacy, while offering a readable magnetic signal for image mapping of material disassemblies at tumor sites. MDPI 2020-12-29 /pmc/articles/PMC7824301/ /pubmed/33383768 http://dx.doi.org/10.3390/nano11010062 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Avugadda, Sahitya Kumar
Wickramasinghe, Sameera
Niculaes, Dina
Ju, Minseon
Lak, Aidin
Silvestri, Niccolò
Nitti, Simone
Roy, Ipsita
Samia, Anna Cristina S.
Pellegrino, Teresa
Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters
title Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters
title_full Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters
title_fullStr Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters
title_full_unstemmed Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters
title_short Uncovering the Magnetic Particle Imaging and Magnetic Resonance Imaging Features of Iron Oxide Nanocube Clusters
title_sort uncovering the magnetic particle imaging and magnetic resonance imaging features of iron oxide nanocube clusters
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824301/
https://www.ncbi.nlm.nih.gov/pubmed/33383768
http://dx.doi.org/10.3390/nano11010062
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