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Paraoxonase Role in Human Neurodegenerative Diseases

The human body has biological redox systems capable of preventing or mitigating the damage caused by increased oxidative stress throughout life. One of them are the paraoxonase (PON) enzymes. The PONs genetic cluster is made up of three members (PON1, PON2, PON3) that share a structural homology, lo...

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Autores principales: Reichert, Cadiele Oliana, Levy, Debora, Bydlowski, Sergio P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824310/
https://www.ncbi.nlm.nih.gov/pubmed/33374313
http://dx.doi.org/10.3390/antiox10010011
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author Reichert, Cadiele Oliana
Levy, Debora
Bydlowski, Sergio P.
author_facet Reichert, Cadiele Oliana
Levy, Debora
Bydlowski, Sergio P.
author_sort Reichert, Cadiele Oliana
collection PubMed
description The human body has biological redox systems capable of preventing or mitigating the damage caused by increased oxidative stress throughout life. One of them are the paraoxonase (PON) enzymes. The PONs genetic cluster is made up of three members (PON1, PON2, PON3) that share a structural homology, located adjacent to chromosome seven. The most studied enzyme is PON1, which is associated with high density lipoprotein (HDL), having paraoxonase, arylesterase and lactonase activities. Due to these characteristics, the enzyme PON1 has been associated with the development of neurodegenerative diseases. Here we update the knowledge about the association of PON enzymes and their polymorphisms and the development of multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and Parkinson’s disease (PD).
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spelling pubmed-78243102021-01-24 Paraoxonase Role in Human Neurodegenerative Diseases Reichert, Cadiele Oliana Levy, Debora Bydlowski, Sergio P. Antioxidants (Basel) Review The human body has biological redox systems capable of preventing or mitigating the damage caused by increased oxidative stress throughout life. One of them are the paraoxonase (PON) enzymes. The PONs genetic cluster is made up of three members (PON1, PON2, PON3) that share a structural homology, located adjacent to chromosome seven. The most studied enzyme is PON1, which is associated with high density lipoprotein (HDL), having paraoxonase, arylesterase and lactonase activities. Due to these characteristics, the enzyme PON1 has been associated with the development of neurodegenerative diseases. Here we update the knowledge about the association of PON enzymes and their polymorphisms and the development of multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and Parkinson’s disease (PD). MDPI 2020-12-24 /pmc/articles/PMC7824310/ /pubmed/33374313 http://dx.doi.org/10.3390/antiox10010011 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Reichert, Cadiele Oliana
Levy, Debora
Bydlowski, Sergio P.
Paraoxonase Role in Human Neurodegenerative Diseases
title Paraoxonase Role in Human Neurodegenerative Diseases
title_full Paraoxonase Role in Human Neurodegenerative Diseases
title_fullStr Paraoxonase Role in Human Neurodegenerative Diseases
title_full_unstemmed Paraoxonase Role in Human Neurodegenerative Diseases
title_short Paraoxonase Role in Human Neurodegenerative Diseases
title_sort paraoxonase role in human neurodegenerative diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824310/
https://www.ncbi.nlm.nih.gov/pubmed/33374313
http://dx.doi.org/10.3390/antiox10010011
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