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Paraoxonase Role in Human Neurodegenerative Diseases
The human body has biological redox systems capable of preventing or mitigating the damage caused by increased oxidative stress throughout life. One of them are the paraoxonase (PON) enzymes. The PONs genetic cluster is made up of three members (PON1, PON2, PON3) that share a structural homology, lo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824310/ https://www.ncbi.nlm.nih.gov/pubmed/33374313 http://dx.doi.org/10.3390/antiox10010011 |
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author | Reichert, Cadiele Oliana Levy, Debora Bydlowski, Sergio P. |
author_facet | Reichert, Cadiele Oliana Levy, Debora Bydlowski, Sergio P. |
author_sort | Reichert, Cadiele Oliana |
collection | PubMed |
description | The human body has biological redox systems capable of preventing or mitigating the damage caused by increased oxidative stress throughout life. One of them are the paraoxonase (PON) enzymes. The PONs genetic cluster is made up of three members (PON1, PON2, PON3) that share a structural homology, located adjacent to chromosome seven. The most studied enzyme is PON1, which is associated with high density lipoprotein (HDL), having paraoxonase, arylesterase and lactonase activities. Due to these characteristics, the enzyme PON1 has been associated with the development of neurodegenerative diseases. Here we update the knowledge about the association of PON enzymes and their polymorphisms and the development of multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and Parkinson’s disease (PD). |
format | Online Article Text |
id | pubmed-7824310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78243102021-01-24 Paraoxonase Role in Human Neurodegenerative Diseases Reichert, Cadiele Oliana Levy, Debora Bydlowski, Sergio P. Antioxidants (Basel) Review The human body has biological redox systems capable of preventing or mitigating the damage caused by increased oxidative stress throughout life. One of them are the paraoxonase (PON) enzymes. The PONs genetic cluster is made up of three members (PON1, PON2, PON3) that share a structural homology, located adjacent to chromosome seven. The most studied enzyme is PON1, which is associated with high density lipoprotein (HDL), having paraoxonase, arylesterase and lactonase activities. Due to these characteristics, the enzyme PON1 has been associated with the development of neurodegenerative diseases. Here we update the knowledge about the association of PON enzymes and their polymorphisms and the development of multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and Parkinson’s disease (PD). MDPI 2020-12-24 /pmc/articles/PMC7824310/ /pubmed/33374313 http://dx.doi.org/10.3390/antiox10010011 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Reichert, Cadiele Oliana Levy, Debora Bydlowski, Sergio P. Paraoxonase Role in Human Neurodegenerative Diseases |
title | Paraoxonase Role in Human Neurodegenerative Diseases |
title_full | Paraoxonase Role in Human Neurodegenerative Diseases |
title_fullStr | Paraoxonase Role in Human Neurodegenerative Diseases |
title_full_unstemmed | Paraoxonase Role in Human Neurodegenerative Diseases |
title_short | Paraoxonase Role in Human Neurodegenerative Diseases |
title_sort | paraoxonase role in human neurodegenerative diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824310/ https://www.ncbi.nlm.nih.gov/pubmed/33374313 http://dx.doi.org/10.3390/antiox10010011 |
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