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Principles of Best Diagnostic Practice in Tissue Repair and Wound Healing: An Expert Consensus

Chronic wound treatment currently relies heavily on visual assessment by clinicians; however, the clinical signs and symptoms of infection and inflammation are unreliable in chronic wounds. The specialty of wound care has witnessed the advent of advanced interventions, such as cellular and/or tissue...

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Autores principales: G. Armstrong, David, Bauer, Karen, Bohn, Greg, Carter, Marissa, Snyder, Robert, Serena, Thomas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824433/
https://www.ncbi.nlm.nih.gov/pubmed/33396217
http://dx.doi.org/10.3390/diagnostics11010050
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author G. Armstrong, David
Bauer, Karen
Bohn, Greg
Carter, Marissa
Snyder, Robert
Serena, Thomas E.
author_facet G. Armstrong, David
Bauer, Karen
Bohn, Greg
Carter, Marissa
Snyder, Robert
Serena, Thomas E.
author_sort G. Armstrong, David
collection PubMed
description Chronic wound treatment currently relies heavily on visual assessment by clinicians; however, the clinical signs and symptoms of infection and inflammation are unreliable in chronic wounds. The specialty of wound care has witnessed the advent of advanced interventions, such as cellular and/or tissue based products (CTP). The success of advanced therapies relies on preparing the wound bed by reducing bacterial burden and inflammation. The lack of diagnostics in chronic wound care leads to uncertainty in the adequacy of wound bed preparation. Recent research suggests that two novel point-of-care diagnostic tests can assist in the detection of chronic inflammation known as elevated neutrophil derived protease activity (EPA) and bacterial pathogenesis known as bacterial protease activity(BPA) in chronic wounds. Despite the evidence, however, clinicians report that incorporating diagnostics into every day practice is challenging and across the globe, they have requested guidance on their use. Methods and Recommendations: A panel of wound care experts, experienced with these tests, met to develop guidelines on their use in wound care practice. The consensus panel concluded that the clinician should test for BPA first. The panel maintained that the risk of invasive infection resulting from the presence of pathogenic bacteria was the greatest threat to the patient’s health. If the BPA test is negative, the panel recommended testing for EPA. In addition, it was suggested that if the wound failed to progress after the elevated BPA was treated and subsequent testing was negative for BPA, the clinician should consider testing for EPA. Conclusions: In this manuscript, the consensus panel suggests pathways for testing, treating, and retesting for EPA and BPA. The panel expects that following the algorithm has the potential to improve healing outcomes, result in more cost-effective use of advanced therapies, and improve antimicrobial stewardship by guiding antimicrobial use.
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spelling pubmed-78244332021-01-24 Principles of Best Diagnostic Practice in Tissue Repair and Wound Healing: An Expert Consensus G. Armstrong, David Bauer, Karen Bohn, Greg Carter, Marissa Snyder, Robert Serena, Thomas E. Diagnostics (Basel) Opinion Chronic wound treatment currently relies heavily on visual assessment by clinicians; however, the clinical signs and symptoms of infection and inflammation are unreliable in chronic wounds. The specialty of wound care has witnessed the advent of advanced interventions, such as cellular and/or tissue based products (CTP). The success of advanced therapies relies on preparing the wound bed by reducing bacterial burden and inflammation. The lack of diagnostics in chronic wound care leads to uncertainty in the adequacy of wound bed preparation. Recent research suggests that two novel point-of-care diagnostic tests can assist in the detection of chronic inflammation known as elevated neutrophil derived protease activity (EPA) and bacterial pathogenesis known as bacterial protease activity(BPA) in chronic wounds. Despite the evidence, however, clinicians report that incorporating diagnostics into every day practice is challenging and across the globe, they have requested guidance on their use. Methods and Recommendations: A panel of wound care experts, experienced with these tests, met to develop guidelines on their use in wound care practice. The consensus panel concluded that the clinician should test for BPA first. The panel maintained that the risk of invasive infection resulting from the presence of pathogenic bacteria was the greatest threat to the patient’s health. If the BPA test is negative, the panel recommended testing for EPA. In addition, it was suggested that if the wound failed to progress after the elevated BPA was treated and subsequent testing was negative for BPA, the clinician should consider testing for EPA. Conclusions: In this manuscript, the consensus panel suggests pathways for testing, treating, and retesting for EPA and BPA. The panel expects that following the algorithm has the potential to improve healing outcomes, result in more cost-effective use of advanced therapies, and improve antimicrobial stewardship by guiding antimicrobial use. MDPI 2020-12-31 /pmc/articles/PMC7824433/ /pubmed/33396217 http://dx.doi.org/10.3390/diagnostics11010050 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Opinion
G. Armstrong, David
Bauer, Karen
Bohn, Greg
Carter, Marissa
Snyder, Robert
Serena, Thomas E.
Principles of Best Diagnostic Practice in Tissue Repair and Wound Healing: An Expert Consensus
title Principles of Best Diagnostic Practice in Tissue Repair and Wound Healing: An Expert Consensus
title_full Principles of Best Diagnostic Practice in Tissue Repair and Wound Healing: An Expert Consensus
title_fullStr Principles of Best Diagnostic Practice in Tissue Repair and Wound Healing: An Expert Consensus
title_full_unstemmed Principles of Best Diagnostic Practice in Tissue Repair and Wound Healing: An Expert Consensus
title_short Principles of Best Diagnostic Practice in Tissue Repair and Wound Healing: An Expert Consensus
title_sort principles of best diagnostic practice in tissue repair and wound healing: an expert consensus
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824433/
https://www.ncbi.nlm.nih.gov/pubmed/33396217
http://dx.doi.org/10.3390/diagnostics11010050
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