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Characteristics, Management and Outcomes of Spondylodiscitis in Children: A Systematic Review

Spondylodiscitis (SD) is the concurrent infection of the intervertebral disc and the adjacent vertebral bodies. Currently, there is a substantial lack of structured reviews about this topic. The aim of this study was to systematically review the available literature in order to determine the main fe...

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Autores principales: Ferri, Irene, Ristori, Gabriele, Lisi, Catiuscia, Galli, Luisa, Chiappini, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824456/
https://www.ncbi.nlm.nih.gov/pubmed/33396379
http://dx.doi.org/10.3390/antibiotics10010030
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author Ferri, Irene
Ristori, Gabriele
Lisi, Catiuscia
Galli, Luisa
Chiappini, Elena
author_facet Ferri, Irene
Ristori, Gabriele
Lisi, Catiuscia
Galli, Luisa
Chiappini, Elena
author_sort Ferri, Irene
collection PubMed
description Spondylodiscitis (SD) is the concurrent infection of the intervertebral disc and the adjacent vertebral bodies. Currently, there is a substantial lack of structured reviews about this topic. The aim of this study was to systematically review the available literature in order to determine the main features of pediatric SD. A systematic search of MEDLINE database was performed, according to the PRISMA guideline recommendations. Clinical features, laboratory data, radiological signs, treatments strategies, and outcomes were summarized. Studies’ quality assessments were performed using the JBI Critical Appraisal Checklists. A total of 35 retrospective studies were analyzed and 340 children were identified. The most frequently affected age class was 0.5–4 years. The most affected site was the lumbar spine. The most commonly reported symptoms were back pain (37.97%) and refusal to walk/to stand/to sit (49.79%). The most frequently identified pathogen was Staphylococcus aureus (n = 33). The most used antibiotics were third generation cephalosporins. The intravenous therapy duration range was 1–25 weeks, the oral therapy duration range was 5 days–36 months. Surgery was used in 5.88% of children. In 29 cases clinical sequelae were documented. This study provides the main features of pediatric SD; it also emphasizes the significant gaps in the literature regarding this topic.
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spelling pubmed-78244562021-01-24 Characteristics, Management and Outcomes of Spondylodiscitis in Children: A Systematic Review Ferri, Irene Ristori, Gabriele Lisi, Catiuscia Galli, Luisa Chiappini, Elena Antibiotics (Basel) Review Spondylodiscitis (SD) is the concurrent infection of the intervertebral disc and the adjacent vertebral bodies. Currently, there is a substantial lack of structured reviews about this topic. The aim of this study was to systematically review the available literature in order to determine the main features of pediatric SD. A systematic search of MEDLINE database was performed, according to the PRISMA guideline recommendations. Clinical features, laboratory data, radiological signs, treatments strategies, and outcomes were summarized. Studies’ quality assessments were performed using the JBI Critical Appraisal Checklists. A total of 35 retrospective studies were analyzed and 340 children were identified. The most frequently affected age class was 0.5–4 years. The most affected site was the lumbar spine. The most commonly reported symptoms were back pain (37.97%) and refusal to walk/to stand/to sit (49.79%). The most frequently identified pathogen was Staphylococcus aureus (n = 33). The most used antibiotics were third generation cephalosporins. The intravenous therapy duration range was 1–25 weeks, the oral therapy duration range was 5 days–36 months. Surgery was used in 5.88% of children. In 29 cases clinical sequelae were documented. This study provides the main features of pediatric SD; it also emphasizes the significant gaps in the literature regarding this topic. MDPI 2020-12-31 /pmc/articles/PMC7824456/ /pubmed/33396379 http://dx.doi.org/10.3390/antibiotics10010030 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ferri, Irene
Ristori, Gabriele
Lisi, Catiuscia
Galli, Luisa
Chiappini, Elena
Characteristics, Management and Outcomes of Spondylodiscitis in Children: A Systematic Review
title Characteristics, Management and Outcomes of Spondylodiscitis in Children: A Systematic Review
title_full Characteristics, Management and Outcomes of Spondylodiscitis in Children: A Systematic Review
title_fullStr Characteristics, Management and Outcomes of Spondylodiscitis in Children: A Systematic Review
title_full_unstemmed Characteristics, Management and Outcomes of Spondylodiscitis in Children: A Systematic Review
title_short Characteristics, Management and Outcomes of Spondylodiscitis in Children: A Systematic Review
title_sort characteristics, management and outcomes of spondylodiscitis in children: a systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824456/
https://www.ncbi.nlm.nih.gov/pubmed/33396379
http://dx.doi.org/10.3390/antibiotics10010030
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