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Fucoidan and Lung Function: Value in Viral Infection
Compromised lung function is a feature of both infection driven and non-infective pathologies. Viral infections—including the current pandemic strain SARS-CoV-2—that affect lung function can cause both acute and long-term chronic damage. SARS-CoV-2 infection suppresses innate immunity and promotes a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824479/ https://www.ncbi.nlm.nih.gov/pubmed/33374149 http://dx.doi.org/10.3390/md19010004 |
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author | Fitton, J. Helen Park, Ah Young Karpiniec, Samuel S. Stringer, Damien N. |
author_facet | Fitton, J. Helen Park, Ah Young Karpiniec, Samuel S. Stringer, Damien N. |
author_sort | Fitton, J. Helen |
collection | PubMed |
description | Compromised lung function is a feature of both infection driven and non-infective pathologies. Viral infections—including the current pandemic strain SARS-CoV-2—that affect lung function can cause both acute and long-term chronic damage. SARS-CoV-2 infection suppresses innate immunity and promotes an inflammatory response. Targeting these aspects of SARS-CoV-2 is important as the pandemic affects greater proportions of the population. In clinical and animal studies, fucoidans have been shown to increase innate immunity and decrease inflammation. In addition, dietary fucoidan has been shown to attenuate pulmonary damage in a model of acute viral infection. Direct inhibition of SARS-CoV-2 in vitro has been described, but is not universal. This short review summarizes the current research on fucoidan with regard to viral lung infections and lung damage. |
format | Online Article Text |
id | pubmed-7824479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78244792021-01-24 Fucoidan and Lung Function: Value in Viral Infection Fitton, J. Helen Park, Ah Young Karpiniec, Samuel S. Stringer, Damien N. Mar Drugs Review Compromised lung function is a feature of both infection driven and non-infective pathologies. Viral infections—including the current pandemic strain SARS-CoV-2—that affect lung function can cause both acute and long-term chronic damage. SARS-CoV-2 infection suppresses innate immunity and promotes an inflammatory response. Targeting these aspects of SARS-CoV-2 is important as the pandemic affects greater proportions of the population. In clinical and animal studies, fucoidans have been shown to increase innate immunity and decrease inflammation. In addition, dietary fucoidan has been shown to attenuate pulmonary damage in a model of acute viral infection. Direct inhibition of SARS-CoV-2 in vitro has been described, but is not universal. This short review summarizes the current research on fucoidan with regard to viral lung infections and lung damage. MDPI 2020-12-24 /pmc/articles/PMC7824479/ /pubmed/33374149 http://dx.doi.org/10.3390/md19010004 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fitton, J. Helen Park, Ah Young Karpiniec, Samuel S. Stringer, Damien N. Fucoidan and Lung Function: Value in Viral Infection |
title | Fucoidan and Lung Function: Value in Viral Infection |
title_full | Fucoidan and Lung Function: Value in Viral Infection |
title_fullStr | Fucoidan and Lung Function: Value in Viral Infection |
title_full_unstemmed | Fucoidan and Lung Function: Value in Viral Infection |
title_short | Fucoidan and Lung Function: Value in Viral Infection |
title_sort | fucoidan and lung function: value in viral infection |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824479/ https://www.ncbi.nlm.nih.gov/pubmed/33374149 http://dx.doi.org/10.3390/md19010004 |
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