Cargando…

Fucoidan and Lung Function: Value in Viral Infection

Compromised lung function is a feature of both infection driven and non-infective pathologies. Viral infections—including the current pandemic strain SARS-CoV-2—that affect lung function can cause both acute and long-term chronic damage. SARS-CoV-2 infection suppresses innate immunity and promotes a...

Descripción completa

Detalles Bibliográficos
Autores principales: Fitton, J. Helen, Park, Ah Young, Karpiniec, Samuel S., Stringer, Damien N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824479/
https://www.ncbi.nlm.nih.gov/pubmed/33374149
http://dx.doi.org/10.3390/md19010004
_version_ 1783640087324524544
author Fitton, J. Helen
Park, Ah Young
Karpiniec, Samuel S.
Stringer, Damien N.
author_facet Fitton, J. Helen
Park, Ah Young
Karpiniec, Samuel S.
Stringer, Damien N.
author_sort Fitton, J. Helen
collection PubMed
description Compromised lung function is a feature of both infection driven and non-infective pathologies. Viral infections—including the current pandemic strain SARS-CoV-2—that affect lung function can cause both acute and long-term chronic damage. SARS-CoV-2 infection suppresses innate immunity and promotes an inflammatory response. Targeting these aspects of SARS-CoV-2 is important as the pandemic affects greater proportions of the population. In clinical and animal studies, fucoidans have been shown to increase innate immunity and decrease inflammation. In addition, dietary fucoidan has been shown to attenuate pulmonary damage in a model of acute viral infection. Direct inhibition of SARS-CoV-2 in vitro has been described, but is not universal. This short review summarizes the current research on fucoidan with regard to viral lung infections and lung damage.
format Online
Article
Text
id pubmed-7824479
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-78244792021-01-24 Fucoidan and Lung Function: Value in Viral Infection Fitton, J. Helen Park, Ah Young Karpiniec, Samuel S. Stringer, Damien N. Mar Drugs Review Compromised lung function is a feature of both infection driven and non-infective pathologies. Viral infections—including the current pandemic strain SARS-CoV-2—that affect lung function can cause both acute and long-term chronic damage. SARS-CoV-2 infection suppresses innate immunity and promotes an inflammatory response. Targeting these aspects of SARS-CoV-2 is important as the pandemic affects greater proportions of the population. In clinical and animal studies, fucoidans have been shown to increase innate immunity and decrease inflammation. In addition, dietary fucoidan has been shown to attenuate pulmonary damage in a model of acute viral infection. Direct inhibition of SARS-CoV-2 in vitro has been described, but is not universal. This short review summarizes the current research on fucoidan with regard to viral lung infections and lung damage. MDPI 2020-12-24 /pmc/articles/PMC7824479/ /pubmed/33374149 http://dx.doi.org/10.3390/md19010004 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fitton, J. Helen
Park, Ah Young
Karpiniec, Samuel S.
Stringer, Damien N.
Fucoidan and Lung Function: Value in Viral Infection
title Fucoidan and Lung Function: Value in Viral Infection
title_full Fucoidan and Lung Function: Value in Viral Infection
title_fullStr Fucoidan and Lung Function: Value in Viral Infection
title_full_unstemmed Fucoidan and Lung Function: Value in Viral Infection
title_short Fucoidan and Lung Function: Value in Viral Infection
title_sort fucoidan and lung function: value in viral infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824479/
https://www.ncbi.nlm.nih.gov/pubmed/33374149
http://dx.doi.org/10.3390/md19010004
work_keys_str_mv AT fittonjhelen fucoidanandlungfunctionvalueinviralinfection
AT parkahyoung fucoidanandlungfunctionvalueinviralinfection
AT karpiniecsamuels fucoidanandlungfunctionvalueinviralinfection
AT stringerdamienn fucoidanandlungfunctionvalueinviralinfection