Cargando…

Probing the Effects of the FGFR-Inhibitor Derazantinib on Vascular Development in Zebrafish Embryos

Angiogenesis is a fundamental developmental process and a hallmark of cancer progression. Receptor tyrosine kinases (RTK) are targets for cancer therapy which may include their action as anti-angiogenic agents. Derazantinib (DZB) is an inhibitor of the fibroblast growth factor receptors (FGFRs) 1–3...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kotini, Maria P., Bachmann, Felix, Spickermann, Jochen, McSheehy, Paul M., Affolter, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824571/ https://www.ncbi.nlm.nih.gov/pubmed/33396726 http://dx.doi.org/10.3390/ph14010025

Ejemplares similares

Derazantinib (ARQ 087) in advanced or inoperable FGFR2 gene fusion-positive intrahepatic cholangiocarcinoma
por: Mazzaferro, Vincenzo, et al.
Publicado: (2018)

Lack of pharmacokinetic interaction between derazantinib and naringin in rats
por: Liu, Ya-nan, et al.
Publicado: (2023)

Vinculin strengthens the endothelial barrier during vascular development
por: van der Stoel, Miesje M, et al.
Publicado: (2022)

Blood Flow Changes Coincide with Cellular Rearrangements during Blood Vessel Pruning in Zebrafish Embryos
por: Kochhan, Eva, et al.
Publicado: (2013)

Correction: Blood Flow Changes Coincide with Cellular Rearrangements during Blood Vessel Pruning in Zebrafish Embryos
por: Kochhan, Eva, et al.
Publicado: (2014)

Treating ICB-resistant glioma with anti-CD40 and mitotic spindle checkpoint controller BAL101553 (lisavanbulin)
por: Genoud, Vassilis, et al.
Publicado: (2021)

Paracrine interactions through FGFR1 and FGFR2 receptors regulate the development of preimplantation mouse chimaeric embryo
por: Krawczyk, Katarzyna, et al.
Publicado: (2022)

Resistance to Selective FGFR Inhibitors in FGFR-Driven Urothelial Cancer
por: Facchinetti, Francesco, et al.
Publicado: (2023)

Prediction of 5-fluorouracil cytotoxicity towards the Walker carcinosarcoma using peak integrals of fluoronucleotides measured by MRS in vivo.
por: McSheehy, P. M., et al.
Publicado: (1989)

Enhanced 5-fluorouracil cytotoxicity and elevated 5-fluoronucleotides in the rat Walker carcinosarcoma following methotrexate pre-treatment: a 19F-MRS study in vivo.
por: McSheehy, P. M., et al.
Publicado: (1992)

Single-cell transcriptomic analysis of vascular endothelial cells in zebrafish embryos
por: Gurung, Suman, et al.
Publicado: (2022)

Developmental Role of Zebrafish Protease-Activated Receptor 1 (PAR1) in the Cardio-Vascular System
por: Ellertsdottir, Elin, et al.
Publicado: (2012)

Spatiotemporal sensitivity of mesoderm specification to FGFR signalling in the Drosophila embryo
por: Yadav, V., et al.
Publicado: (2021)

Dual targeting of FGFR3 and ERBB3 enhances the efficacy of FGFR inhibitors in FGFR3 fusion-driven bladder cancer
por: Weickhardt, Andrew J., et al.
Publicado: (2022)

FGFR redundancy limits the efficacy of FGFR4-selective inhibitors in hepatocellular carcinoma
por: Tao, Zhanchao, et al.
Publicado: (2022)

Futibatinib, an Irreversible FGFR1-4 Inhibitor for the Treatment of FGFR-Aberrant Tumors
por: Javle, Milind, et al.
Publicado: (2023)

A Caged Ret Kinase Inhibitor and its Effect on Motoneuron Development in Zebrafish Embryos
por: Bliman, David, et al.
Publicado: (2015)

Infection of Zebrafish Embryos with Intracellular Bacterial Pathogens
por: Benard, Erica L., et al.
Publicado: (2012)

Targeting the Src Pathway Enhances the Efficacy of Selective FGFR Inhibitors in Urothelial Cancers with FGFR3 Alterations
por: Lima, Nadia Carvalho, et al.
Publicado: (2020)

(18)F-labeled FGFR1 peptide: a new PET probe for subtype FGFR1 receptor imaging
por: Chen, Yang, et al.
Publicado: (2023)

Automated high-throughput heartbeat quantification in medaka and zebrafish embryos under physiological conditions
por: Gierten, Jakob, et al.
Publicado: (2020)

Stable Vascular Connections and Remodeling Require Full Expression of VE-Cadherin in Zebrafish Embryos
por: Montero-Balaguer, Mercedes, et al.
Publicado: (2009)

Proteomics of early zebrafish embryos
por: Link, Vinzenz, et al.
Publicado: (2006)

FLPe functions in zebrafish embryos
por: Wong, Andrew C., et al.
Publicado: (2010)

Microbead Implantation in the Zebrafish Embryo
por: Gerlach, Gary F., et al.
Publicado: (2015)

The antiangiogenic effects of polyisoprenylated cysteinyl amide inhibitors in HUVEC, chick embryo and zebrafish is dependent on the polyisoprenyl moiety
por: Nkembo, Augustine T., et al.
Publicado: (2016)

Tumour T(1) changes in vivo are highly predictive of response to chemotherapy and reflect the number of viable tumour cells – a preclinical MR study in mice
por: Weidensteiner, Claudia, et al.
Publicado: (2014)

Quantifying endothelial cell proliferation in the zebrafish embryo
por: Bowley, George, et al.
Publicado: (2021)

Production of Haploid Zebrafish Embryos by In Vitro Fertilization
por: Kroeger, Paul T., et al.
Publicado: (2014)

Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos
por: Weijts, Bart, et al.
Publicado: (2018)

Clinical development and management of adverse events associated with FGFR inhibitors
por: Subbiah, Vivek, et al.
Publicado: (2023)

Intrahepatic Cholangiocarcinoma: State of the Art of FGFR Inhibitors
por: Wu, Tianyu, et al.
Publicado: (2021)

Mtmr8 is essential for vasculature development in zebrafish embryos
por: Mei, Jie, et al.
Publicado: (2010)

Characterization of trace metal content in the developing zebrafish embryo
por: Thomason, Rebecca T., et al.
Publicado: (2017)

Stage-Related Neurotoxicity of BPA in the Development of Zebrafish Embryos
por: Liu, Jianjun, et al.
Publicado: (2023)

Bcl‐2 inhibitors enhance FGFR inhibitor‐induced mitochondrial‐dependent cell death in FGFR2‐mutant endometrial cancer
por: Packer, Leisl M., et al.
Publicado: (2019)

Generating Chimeric Zebrafish Embryos by Transplantation
por: Kemp, Hilary A., et al.
Publicado: (2009)

Neurogenesis in zebrafish – from embryo to adult
por: Schmidt, Rebecca, et al.
Publicado: (2013)

Metabolic Profile Analysis of Zebrafish Embryos
por: Gibert, Yann, et al.
Publicado: (2013)

Dietary Contaminants and Their Effects on Zebrafish Embryos
por: Tye, Marc, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_vsd1q8he2ehbe2o9tv6c850pd9