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Probiotic Alternative to Chlorhexidine in Periodontal Therapy: Evaluation of Clinical and Microbiological Parameters

Periodontitis consists of a progressive destruction of tooth-supporting tissues. Considering that probiotics are being proposed as a support to the gold standard treatment Scaling-and-Root-Planing (SRP), this study aims to assess two new formulations (toothpaste and chewing-gum). 60 patients were ra...

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Autores principales: Butera, Andrea, Gallo, Simone, Maiorani, Carolina, Molino, Domenico, Chiesa, Alessandro, Preda, Camilla, Esposito, Francesca, Scribante, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824624/
https://www.ncbi.nlm.nih.gov/pubmed/33383903
http://dx.doi.org/10.3390/microorganisms9010069
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author Butera, Andrea
Gallo, Simone
Maiorani, Carolina
Molino, Domenico
Chiesa, Alessandro
Preda, Camilla
Esposito, Francesca
Scribante, Andrea
author_facet Butera, Andrea
Gallo, Simone
Maiorani, Carolina
Molino, Domenico
Chiesa, Alessandro
Preda, Camilla
Esposito, Francesca
Scribante, Andrea
author_sort Butera, Andrea
collection PubMed
description Periodontitis consists of a progressive destruction of tooth-supporting tissues. Considering that probiotics are being proposed as a support to the gold standard treatment Scaling-and-Root-Planing (SRP), this study aims to assess two new formulations (toothpaste and chewing-gum). 60 patients were randomly assigned to three domiciliary hygiene treatments: Group 1 (SRP + chlorhexidine-based toothpaste) (control), Group 2 (SRP + probiotics-based toothpaste) and Group 3 (SRP + probiotics-based toothpaste + probiotics-based chewing-gum). At baseline (T(0)) and after 3 and 6 months (T(1)–T(2)), periodontal clinical parameters were recorded, along with microbiological ones by means of a commercial kit. As to the former, no significant differences were shown at T(1) or T(2), neither in controls for any index, nor in the experimental groups for adherent gingiva and gingival recession. Conversely, some significant differences were found in Group 2 and 3 for the other clinical indexes tested. Considering microbiological parameters, no significant differences were detected compared to baseline values for any group, except in Group 2 and 3 at T(2) only for the percentage of the orange complex pathogens and for the copies/microliter of Prevotella intermedia and Fusobacterium nucleatum. Accordingly, although colonization of probiotic bacteria has not been assessed in this study, the probiotics tested represent a valid support to SRP with a benefit on several clinical indexes and on specific periodontopathogens. Despite this promising action, the relationship between the use of probiotics and improvement in clinical parameters is still unclear and deserves to be further explored.
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spelling pubmed-78246242021-01-24 Probiotic Alternative to Chlorhexidine in Periodontal Therapy: Evaluation of Clinical and Microbiological Parameters Butera, Andrea Gallo, Simone Maiorani, Carolina Molino, Domenico Chiesa, Alessandro Preda, Camilla Esposito, Francesca Scribante, Andrea Microorganisms Article Periodontitis consists of a progressive destruction of tooth-supporting tissues. Considering that probiotics are being proposed as a support to the gold standard treatment Scaling-and-Root-Planing (SRP), this study aims to assess two new formulations (toothpaste and chewing-gum). 60 patients were randomly assigned to three domiciliary hygiene treatments: Group 1 (SRP + chlorhexidine-based toothpaste) (control), Group 2 (SRP + probiotics-based toothpaste) and Group 3 (SRP + probiotics-based toothpaste + probiotics-based chewing-gum). At baseline (T(0)) and after 3 and 6 months (T(1)–T(2)), periodontal clinical parameters were recorded, along with microbiological ones by means of a commercial kit. As to the former, no significant differences were shown at T(1) or T(2), neither in controls for any index, nor in the experimental groups for adherent gingiva and gingival recession. Conversely, some significant differences were found in Group 2 and 3 for the other clinical indexes tested. Considering microbiological parameters, no significant differences were detected compared to baseline values for any group, except in Group 2 and 3 at T(2) only for the percentage of the orange complex pathogens and for the copies/microliter of Prevotella intermedia and Fusobacterium nucleatum. Accordingly, although colonization of probiotic bacteria has not been assessed in this study, the probiotics tested represent a valid support to SRP with a benefit on several clinical indexes and on specific periodontopathogens. Despite this promising action, the relationship between the use of probiotics and improvement in clinical parameters is still unclear and deserves to be further explored. MDPI 2020-12-29 /pmc/articles/PMC7824624/ /pubmed/33383903 http://dx.doi.org/10.3390/microorganisms9010069 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Butera, Andrea
Gallo, Simone
Maiorani, Carolina
Molino, Domenico
Chiesa, Alessandro
Preda, Camilla
Esposito, Francesca
Scribante, Andrea
Probiotic Alternative to Chlorhexidine in Periodontal Therapy: Evaluation of Clinical and Microbiological Parameters
title Probiotic Alternative to Chlorhexidine in Periodontal Therapy: Evaluation of Clinical and Microbiological Parameters
title_full Probiotic Alternative to Chlorhexidine in Periodontal Therapy: Evaluation of Clinical and Microbiological Parameters
title_fullStr Probiotic Alternative to Chlorhexidine in Periodontal Therapy: Evaluation of Clinical and Microbiological Parameters
title_full_unstemmed Probiotic Alternative to Chlorhexidine in Periodontal Therapy: Evaluation of Clinical and Microbiological Parameters
title_short Probiotic Alternative to Chlorhexidine in Periodontal Therapy: Evaluation of Clinical and Microbiological Parameters
title_sort probiotic alternative to chlorhexidine in periodontal therapy: evaluation of clinical and microbiological parameters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824624/
https://www.ncbi.nlm.nih.gov/pubmed/33383903
http://dx.doi.org/10.3390/microorganisms9010069
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