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Evidence of Oligoclonal Bands Does Not Exclude Non-Inflammatory Neurological Diseases

Cerebrospinal fluid analysis is an essential part of the diagnostic workup in various neurological disorders. Evidence of an intrathecal immunoglobulin synthesis, as demonstrated by Reiber’s diagram or the more sensitive oligoclonal bands (OCB), are typical for neuroinflammatory diseases, and normal...

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Autores principales: Pannewitz-Makaj, Katharina, Wurster, Ulrich, Jendretzky, Konstantin Fritz, Gingele, Stefan, Sühs, Kurt-Wolfram, Stangel, Martin, Skripuletz, Thomas, Schwenkenbecher, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824674/
https://www.ncbi.nlm.nih.gov/pubmed/33379245
http://dx.doi.org/10.3390/diagnostics11010037
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author Pannewitz-Makaj, Katharina
Wurster, Ulrich
Jendretzky, Konstantin Fritz
Gingele, Stefan
Sühs, Kurt-Wolfram
Stangel, Martin
Skripuletz, Thomas
Schwenkenbecher, Philipp
author_facet Pannewitz-Makaj, Katharina
Wurster, Ulrich
Jendretzky, Konstantin Fritz
Gingele, Stefan
Sühs, Kurt-Wolfram
Stangel, Martin
Skripuletz, Thomas
Schwenkenbecher, Philipp
author_sort Pannewitz-Makaj, Katharina
collection PubMed
description Cerebrospinal fluid analysis is an essential part of the diagnostic workup in various neurological disorders. Evidence of an intrathecal immunoglobulin synthesis, as demonstrated by Reiber’s diagram or the more sensitive oligoclonal bands (OCB), are typical for neuroinflammatory diseases, and normally not expected in non-inflammatory neurological diseases. Therefore, patients with non-inflammatory neurological diseases are often used in control groups in studies investigating autoimmune diseases of the central nervous system. However, data about the frequency of intrathecal immunoglobulin synthesis in non-inflammatory neurological disease are scarce. The cerebrospinal fluid (CSF) records of a total of 3622 patients were screened and 2114 patients included with presumably non-inflammatory neurological diseases like dementia, idiopathic peripheral neuropathy, motoneuron disease, stroke, and epileptic seizures. Evidence of an intrathecal immunoglobulin synthesis can be found with low frequency also in non-inflammatory neurological diseases. A much higher rate of patients showed intrathecal immunoglobulin synthesis as demonstrated by OCB than by Reiber’s diagram. In patients with disorders of the peripheral nervous system the frequency of OCB was much lower than in patients presenting with central nervous system manifestations. Evidence of an intrathecal immunoglobulin synthesis should not automatically lead to exclusion of non-inflammatory neurological diseases but should rather prompt the way to investigate for the origin of the intrathecal immunoglobulin synthesis.
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spelling pubmed-78246742021-01-24 Evidence of Oligoclonal Bands Does Not Exclude Non-Inflammatory Neurological Diseases Pannewitz-Makaj, Katharina Wurster, Ulrich Jendretzky, Konstantin Fritz Gingele, Stefan Sühs, Kurt-Wolfram Stangel, Martin Skripuletz, Thomas Schwenkenbecher, Philipp Diagnostics (Basel) Article Cerebrospinal fluid analysis is an essential part of the diagnostic workup in various neurological disorders. Evidence of an intrathecal immunoglobulin synthesis, as demonstrated by Reiber’s diagram or the more sensitive oligoclonal bands (OCB), are typical for neuroinflammatory diseases, and normally not expected in non-inflammatory neurological diseases. Therefore, patients with non-inflammatory neurological diseases are often used in control groups in studies investigating autoimmune diseases of the central nervous system. However, data about the frequency of intrathecal immunoglobulin synthesis in non-inflammatory neurological disease are scarce. The cerebrospinal fluid (CSF) records of a total of 3622 patients were screened and 2114 patients included with presumably non-inflammatory neurological diseases like dementia, idiopathic peripheral neuropathy, motoneuron disease, stroke, and epileptic seizures. Evidence of an intrathecal immunoglobulin synthesis can be found with low frequency also in non-inflammatory neurological diseases. A much higher rate of patients showed intrathecal immunoglobulin synthesis as demonstrated by OCB than by Reiber’s diagram. In patients with disorders of the peripheral nervous system the frequency of OCB was much lower than in patients presenting with central nervous system manifestations. Evidence of an intrathecal immunoglobulin synthesis should not automatically lead to exclusion of non-inflammatory neurological diseases but should rather prompt the way to investigate for the origin of the intrathecal immunoglobulin synthesis. MDPI 2020-12-28 /pmc/articles/PMC7824674/ /pubmed/33379245 http://dx.doi.org/10.3390/diagnostics11010037 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pannewitz-Makaj, Katharina
Wurster, Ulrich
Jendretzky, Konstantin Fritz
Gingele, Stefan
Sühs, Kurt-Wolfram
Stangel, Martin
Skripuletz, Thomas
Schwenkenbecher, Philipp
Evidence of Oligoclonal Bands Does Not Exclude Non-Inflammatory Neurological Diseases
title Evidence of Oligoclonal Bands Does Not Exclude Non-Inflammatory Neurological Diseases
title_full Evidence of Oligoclonal Bands Does Not Exclude Non-Inflammatory Neurological Diseases
title_fullStr Evidence of Oligoclonal Bands Does Not Exclude Non-Inflammatory Neurological Diseases
title_full_unstemmed Evidence of Oligoclonal Bands Does Not Exclude Non-Inflammatory Neurological Diseases
title_short Evidence of Oligoclonal Bands Does Not Exclude Non-Inflammatory Neurological Diseases
title_sort evidence of oligoclonal bands does not exclude non-inflammatory neurological diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824674/
https://www.ncbi.nlm.nih.gov/pubmed/33379245
http://dx.doi.org/10.3390/diagnostics11010037
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