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Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients

Patients with chronic diseases are at increased risk of complications following infection. It remains, however, unknown to what extend they are protected against vaccine-preventable diseases. We assessed seroprevalence of antibodies against diphtheria, tetanus and pertussis to evaluate whether curre...

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Autores principales: Boey, Lise, Bosmans, Eline, Ferreira, Liane Braz, Heyvaert, Nathalie, Nelen, Melissa, Smans, Lisa, Tuerlinckx, Hanne, Roelants, Mathieu, Claes, Kathleen, Derdelinckx, Inge, Janssens, Wim, Mathieu, Chantal, Van Cleemput, Johan, Vos, Robin, Desombere, Isabelle, Vandermeulen, Corinne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824683/
https://www.ncbi.nlm.nih.gov/pubmed/33406698
http://dx.doi.org/10.3390/vaccines9010018
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author Boey, Lise
Bosmans, Eline
Ferreira, Liane Braz
Heyvaert, Nathalie
Nelen, Melissa
Smans, Lisa
Tuerlinckx, Hanne
Roelants, Mathieu
Claes, Kathleen
Derdelinckx, Inge
Janssens, Wim
Mathieu, Chantal
Van Cleemput, Johan
Vos, Robin
Desombere, Isabelle
Vandermeulen, Corinne
author_facet Boey, Lise
Bosmans, Eline
Ferreira, Liane Braz
Heyvaert, Nathalie
Nelen, Melissa
Smans, Lisa
Tuerlinckx, Hanne
Roelants, Mathieu
Claes, Kathleen
Derdelinckx, Inge
Janssens, Wim
Mathieu, Chantal
Van Cleemput, Johan
Vos, Robin
Desombere, Isabelle
Vandermeulen, Corinne
author_sort Boey, Lise
collection PubMed
description Patients with chronic diseases are at increased risk of complications following infection. It remains, however, unknown to what extend they are protected against vaccine-preventable diseases. We assessed seroprevalence of antibodies against diphtheria, tetanus and pertussis to evaluate whether current vaccination programs in Belgium are adequate. Antibody titers were assessed with a bead-based multiplex assay in serum of 1052 adults with chronic diseases. We included patients with diabetes mellitus type 1 (DM1) (n = 172), DM2 (n = 77), chronic kidney disease (n = 130), chronic obstructive pulmonary disease (COPD) (n = 170), heart failure (n = 77), HIV (n = 196) and solid organ transplant (SOT) recipients (n = 230). Factors associated with seroprevalence were analysed with multiple logistic regression. We found seroprotective titers in 29% for diphtheria (≥0.1 IU/mL), in 83% for tetanus (≥0.1 IU/mL) and 22% had antibodies against pertussis (≥5 IU/mL). Seroprotection rates were higher (p < 0.001) when vaccinated within the last ten years. Furthermore, diphtheria seroprotection decreased with age (p < 0.001). Tetanus seroprotection was less reached in women (p < 0.001) and older age groups (p < 0.001). For pertussis, women had more often a titer suggestive of a recent infection or vaccination (≥100 IU/mL, p < 0.01). We conclude that except for tetanus, the vast majority of at-risk patients remains susceptible to vaccine-preventable diseases such as diphtheria and pertussis.
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spelling pubmed-78246832021-01-24 Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients Boey, Lise Bosmans, Eline Ferreira, Liane Braz Heyvaert, Nathalie Nelen, Melissa Smans, Lisa Tuerlinckx, Hanne Roelants, Mathieu Claes, Kathleen Derdelinckx, Inge Janssens, Wim Mathieu, Chantal Van Cleemput, Johan Vos, Robin Desombere, Isabelle Vandermeulen, Corinne Vaccines (Basel) Article Patients with chronic diseases are at increased risk of complications following infection. It remains, however, unknown to what extend they are protected against vaccine-preventable diseases. We assessed seroprevalence of antibodies against diphtheria, tetanus and pertussis to evaluate whether current vaccination programs in Belgium are adequate. Antibody titers were assessed with a bead-based multiplex assay in serum of 1052 adults with chronic diseases. We included patients with diabetes mellitus type 1 (DM1) (n = 172), DM2 (n = 77), chronic kidney disease (n = 130), chronic obstructive pulmonary disease (COPD) (n = 170), heart failure (n = 77), HIV (n = 196) and solid organ transplant (SOT) recipients (n = 230). Factors associated with seroprevalence were analysed with multiple logistic regression. We found seroprotective titers in 29% for diphtheria (≥0.1 IU/mL), in 83% for tetanus (≥0.1 IU/mL) and 22% had antibodies against pertussis (≥5 IU/mL). Seroprotection rates were higher (p < 0.001) when vaccinated within the last ten years. Furthermore, diphtheria seroprotection decreased with age (p < 0.001). Tetanus seroprotection was less reached in women (p < 0.001) and older age groups (p < 0.001). For pertussis, women had more often a titer suggestive of a recent infection or vaccination (≥100 IU/mL, p < 0.01). We conclude that except for tetanus, the vast majority of at-risk patients remains susceptible to vaccine-preventable diseases such as diphtheria and pertussis. MDPI 2021-01-04 /pmc/articles/PMC7824683/ /pubmed/33406698 http://dx.doi.org/10.3390/vaccines9010018 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Boey, Lise
Bosmans, Eline
Ferreira, Liane Braz
Heyvaert, Nathalie
Nelen, Melissa
Smans, Lisa
Tuerlinckx, Hanne
Roelants, Mathieu
Claes, Kathleen
Derdelinckx, Inge
Janssens, Wim
Mathieu, Chantal
Van Cleemput, Johan
Vos, Robin
Desombere, Isabelle
Vandermeulen, Corinne
Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients
title Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients
title_full Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients
title_fullStr Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients
title_full_unstemmed Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients
title_short Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients
title_sort seroprevalence of antibodies against diphtheria, tetanus and pertussis in adult at-risk patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824683/
https://www.ncbi.nlm.nih.gov/pubmed/33406698
http://dx.doi.org/10.3390/vaccines9010018
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