Cargando…
Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients
Patients with chronic diseases are at increased risk of complications following infection. It remains, however, unknown to what extend they are protected against vaccine-preventable diseases. We assessed seroprevalence of antibodies against diphtheria, tetanus and pertussis to evaluate whether curre...
Autores principales: | , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824683/ https://www.ncbi.nlm.nih.gov/pubmed/33406698 http://dx.doi.org/10.3390/vaccines9010018 |
_version_ | 1783640137776758784 |
---|---|
author | Boey, Lise Bosmans, Eline Ferreira, Liane Braz Heyvaert, Nathalie Nelen, Melissa Smans, Lisa Tuerlinckx, Hanne Roelants, Mathieu Claes, Kathleen Derdelinckx, Inge Janssens, Wim Mathieu, Chantal Van Cleemput, Johan Vos, Robin Desombere, Isabelle Vandermeulen, Corinne |
author_facet | Boey, Lise Bosmans, Eline Ferreira, Liane Braz Heyvaert, Nathalie Nelen, Melissa Smans, Lisa Tuerlinckx, Hanne Roelants, Mathieu Claes, Kathleen Derdelinckx, Inge Janssens, Wim Mathieu, Chantal Van Cleemput, Johan Vos, Robin Desombere, Isabelle Vandermeulen, Corinne |
author_sort | Boey, Lise |
collection | PubMed |
description | Patients with chronic diseases are at increased risk of complications following infection. It remains, however, unknown to what extend they are protected against vaccine-preventable diseases. We assessed seroprevalence of antibodies against diphtheria, tetanus and pertussis to evaluate whether current vaccination programs in Belgium are adequate. Antibody titers were assessed with a bead-based multiplex assay in serum of 1052 adults with chronic diseases. We included patients with diabetes mellitus type 1 (DM1) (n = 172), DM2 (n = 77), chronic kidney disease (n = 130), chronic obstructive pulmonary disease (COPD) (n = 170), heart failure (n = 77), HIV (n = 196) and solid organ transplant (SOT) recipients (n = 230). Factors associated with seroprevalence were analysed with multiple logistic regression. We found seroprotective titers in 29% for diphtheria (≥0.1 IU/mL), in 83% for tetanus (≥0.1 IU/mL) and 22% had antibodies against pertussis (≥5 IU/mL). Seroprotection rates were higher (p < 0.001) when vaccinated within the last ten years. Furthermore, diphtheria seroprotection decreased with age (p < 0.001). Tetanus seroprotection was less reached in women (p < 0.001) and older age groups (p < 0.001). For pertussis, women had more often a titer suggestive of a recent infection or vaccination (≥100 IU/mL, p < 0.01). We conclude that except for tetanus, the vast majority of at-risk patients remains susceptible to vaccine-preventable diseases such as diphtheria and pertussis. |
format | Online Article Text |
id | pubmed-7824683 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78246832021-01-24 Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients Boey, Lise Bosmans, Eline Ferreira, Liane Braz Heyvaert, Nathalie Nelen, Melissa Smans, Lisa Tuerlinckx, Hanne Roelants, Mathieu Claes, Kathleen Derdelinckx, Inge Janssens, Wim Mathieu, Chantal Van Cleemput, Johan Vos, Robin Desombere, Isabelle Vandermeulen, Corinne Vaccines (Basel) Article Patients with chronic diseases are at increased risk of complications following infection. It remains, however, unknown to what extend they are protected against vaccine-preventable diseases. We assessed seroprevalence of antibodies against diphtheria, tetanus and pertussis to evaluate whether current vaccination programs in Belgium are adequate. Antibody titers were assessed with a bead-based multiplex assay in serum of 1052 adults with chronic diseases. We included patients with diabetes mellitus type 1 (DM1) (n = 172), DM2 (n = 77), chronic kidney disease (n = 130), chronic obstructive pulmonary disease (COPD) (n = 170), heart failure (n = 77), HIV (n = 196) and solid organ transplant (SOT) recipients (n = 230). Factors associated with seroprevalence were analysed with multiple logistic regression. We found seroprotective titers in 29% for diphtheria (≥0.1 IU/mL), in 83% for tetanus (≥0.1 IU/mL) and 22% had antibodies against pertussis (≥5 IU/mL). Seroprotection rates were higher (p < 0.001) when vaccinated within the last ten years. Furthermore, diphtheria seroprotection decreased with age (p < 0.001). Tetanus seroprotection was less reached in women (p < 0.001) and older age groups (p < 0.001). For pertussis, women had more often a titer suggestive of a recent infection or vaccination (≥100 IU/mL, p < 0.01). We conclude that except for tetanus, the vast majority of at-risk patients remains susceptible to vaccine-preventable diseases such as diphtheria and pertussis. MDPI 2021-01-04 /pmc/articles/PMC7824683/ /pubmed/33406698 http://dx.doi.org/10.3390/vaccines9010018 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Boey, Lise Bosmans, Eline Ferreira, Liane Braz Heyvaert, Nathalie Nelen, Melissa Smans, Lisa Tuerlinckx, Hanne Roelants, Mathieu Claes, Kathleen Derdelinckx, Inge Janssens, Wim Mathieu, Chantal Van Cleemput, Johan Vos, Robin Desombere, Isabelle Vandermeulen, Corinne Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients |
title | Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients |
title_full | Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients |
title_fullStr | Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients |
title_full_unstemmed | Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients |
title_short | Seroprevalence of Antibodies against Diphtheria, Tetanus and Pertussis in Adult At-Risk Patients |
title_sort | seroprevalence of antibodies against diphtheria, tetanus and pertussis in adult at-risk patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824683/ https://www.ncbi.nlm.nih.gov/pubmed/33406698 http://dx.doi.org/10.3390/vaccines9010018 |
work_keys_str_mv | AT boeylise seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients AT bosmanseline seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients AT ferreiralianebraz seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients AT heyvaertnathalie seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients AT nelenmelissa seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients AT smanslisa seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients AT tuerlinckxhanne seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients AT roelantsmathieu seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients AT claeskathleen seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients AT derdelinckxinge seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients AT janssenswim seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients AT mathieuchantal seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients AT vancleemputjohan seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients AT vosrobin seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients AT desombereisabelle seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients AT vandermeulencorinne seroprevalenceofantibodiesagainstdiphtheriatetanusandpertussisinadultatriskpatients |