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Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis

Helicobacter pylori (H. pylori) is a bacterial pathogen implicated in gastritis, gastric ulceration, and gastric carcinoma. This study aimed to synthesize literature in providing evidence on the causative role of H. pylori in gastric carcinoma development. This study is based on assessing public lit...

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Autores principales: Holmes, Laurens, Rios, Jasmine, Berice, Betyna, Benson, Jacqueline, Bafford, Nastocia, Parson, Kadedrah, Halloran, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824775/
https://www.ncbi.nlm.nih.gov/pubmed/33466356
http://dx.doi.org/10.3390/medicines8010001
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author Holmes, Laurens
Rios, Jasmine
Berice, Betyna
Benson, Jacqueline
Bafford, Nastocia
Parson, Kadedrah
Halloran, Daniel
author_facet Holmes, Laurens
Rios, Jasmine
Berice, Betyna
Benson, Jacqueline
Bafford, Nastocia
Parson, Kadedrah
Halloran, Daniel
author_sort Holmes, Laurens
collection PubMed
description Helicobacter pylori (H. pylori) is a bacterial pathogen implicated in gastritis, gastric ulceration, and gastric carcinoma. This study aimed to synthesize literature in providing evidence on the causative role of H. pylori in gastric carcinoma development. This study is based on assessing public literature using an applied meta-analysis, namely, quantitative evidence synthesis (QES). The analytic procedure uses DerSimonian-Laird, including assessing heterogeneity. The QES also utilizes meta-regression and the environmental effect associated with H. pylori in gastric cancer development. Eighteen studies are included in the QES. There is increased prevalence of H. pylori exposure among the cases. The heterogeneity between the CES and individual effect sizes is also significant. Despite controlling for the confoundings, there is increased exposure to H. pylori among the gastric cancer cases, regardless of the differences in the geographic location. H. pylori in this synthesized literature illustrates the contributory role of this microbe in gastric carcinoma. Additionally, regardless of geographic locale, namely, South Korea or Spain, H. pylori is implicated in gastric cancer development.
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spelling pubmed-78247752021-01-24 Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis Holmes, Laurens Rios, Jasmine Berice, Betyna Benson, Jacqueline Bafford, Nastocia Parson, Kadedrah Halloran, Daniel Medicines (Basel) Article Helicobacter pylori (H. pylori) is a bacterial pathogen implicated in gastritis, gastric ulceration, and gastric carcinoma. This study aimed to synthesize literature in providing evidence on the causative role of H. pylori in gastric carcinoma development. This study is based on assessing public literature using an applied meta-analysis, namely, quantitative evidence synthesis (QES). The analytic procedure uses DerSimonian-Laird, including assessing heterogeneity. The QES also utilizes meta-regression and the environmental effect associated with H. pylori in gastric cancer development. Eighteen studies are included in the QES. There is increased prevalence of H. pylori exposure among the cases. The heterogeneity between the CES and individual effect sizes is also significant. Despite controlling for the confoundings, there is increased exposure to H. pylori among the gastric cancer cases, regardless of the differences in the geographic location. H. pylori in this synthesized literature illustrates the contributory role of this microbe in gastric carcinoma. Additionally, regardless of geographic locale, namely, South Korea or Spain, H. pylori is implicated in gastric cancer development. MDPI 2021-01-05 /pmc/articles/PMC7824775/ /pubmed/33466356 http://dx.doi.org/10.3390/medicines8010001 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Holmes, Laurens
Rios, Jasmine
Berice, Betyna
Benson, Jacqueline
Bafford, Nastocia
Parson, Kadedrah
Halloran, Daniel
Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis
title Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis
title_full Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis
title_fullStr Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis
title_full_unstemmed Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis
title_short Predictive Effect of Helicobacter pylori in Gastric Carcinoma Development: Systematic Review and Quantitative Evidence Synthesis
title_sort predictive effect of helicobacter pylori in gastric carcinoma development: systematic review and quantitative evidence synthesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824775/
https://www.ncbi.nlm.nih.gov/pubmed/33466356
http://dx.doi.org/10.3390/medicines8010001
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