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Evaluation of Chemical Composition, Radical Scavenging and Antitumor Activities of Satureja hortensis L. Herb Extracts

Satureja hortensis L. is an annual herbaceous plant of the Lamiaceae Lindl. family. S. hortensis L., related to thyme and rosemary, is used as spice and traditional medicinal herb in Europe. Mainly due to the polyphenols contained in S. hortensis L., this plant exhibits multiple biological effects....

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Autores principales: Bimbiraitė-Survilienė, Kristina, Stankevičius, Mantas, Šuštauskaitė, Simona, Gęgotek, Agnieszka, Maruška, Audrius, Skrzydlewska, Elżbieta, Barsteigienė, Zita, Akuņeca, Ieva, Ragažinskienė, Ona, Lukošius, Audronis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824789/
https://www.ncbi.nlm.nih.gov/pubmed/33466256
http://dx.doi.org/10.3390/antiox10010053
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author Bimbiraitė-Survilienė, Kristina
Stankevičius, Mantas
Šuštauskaitė, Simona
Gęgotek, Agnieszka
Maruška, Audrius
Skrzydlewska, Elżbieta
Barsteigienė, Zita
Akuņeca, Ieva
Ragažinskienė, Ona
Lukošius, Audronis
author_facet Bimbiraitė-Survilienė, Kristina
Stankevičius, Mantas
Šuštauskaitė, Simona
Gęgotek, Agnieszka
Maruška, Audrius
Skrzydlewska, Elżbieta
Barsteigienė, Zita
Akuņeca, Ieva
Ragažinskienė, Ona
Lukošius, Audronis
author_sort Bimbiraitė-Survilienė, Kristina
collection PubMed
description Satureja hortensis L. is an annual herbaceous plant of the Lamiaceae Lindl. family. S. hortensis L., related to thyme and rosemary, is used as spice and traditional medicinal herb in Europe. Mainly due to the polyphenols contained in S. hortensis L., this plant exhibits multiple biological effects. However, therapeutic effects on cells, including skin tumors, have not yet been studied. Therefore, the aim of this study was to compare the composition and the resulting antioxidant as well as biological properties [on melanocytes and melanoma cells] of summer, savory growing in botanical garden of Vytautas Magnus University in middle Lithuania climatic conditions, collected during various phases of vegetation. It has been shown that the budding phase alcohol extract of this plant contains the largest amounts of polyphenols, including rutin and rosemary acid, which promote the radical scavenging activity and antioxidant properties. In contrast, the extract from the massive flowering phase already at a concentration of 12.5 µg/mL reduces the survival of melanoma cells to 60% with 90% melanocytes survival. In addition, extracts from beginning of flowering and end of flowering at a concentration of 25 µg/mL, containing significantly less rutin and rosmarinic acid, in combination with irradiation of cells with UVB, significantly increased the lipid peroxidation process, particularly in melanoma cells. These data indicate the possibility of using extracts from S. hortensis L. to modulate/differentiate the metabolism of normal and tumor skin cells.
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spelling pubmed-78247892021-01-24 Evaluation of Chemical Composition, Radical Scavenging and Antitumor Activities of Satureja hortensis L. Herb Extracts Bimbiraitė-Survilienė, Kristina Stankevičius, Mantas Šuštauskaitė, Simona Gęgotek, Agnieszka Maruška, Audrius Skrzydlewska, Elżbieta Barsteigienė, Zita Akuņeca, Ieva Ragažinskienė, Ona Lukošius, Audronis Antioxidants (Basel) Article Satureja hortensis L. is an annual herbaceous plant of the Lamiaceae Lindl. family. S. hortensis L., related to thyme and rosemary, is used as spice and traditional medicinal herb in Europe. Mainly due to the polyphenols contained in S. hortensis L., this plant exhibits multiple biological effects. However, therapeutic effects on cells, including skin tumors, have not yet been studied. Therefore, the aim of this study was to compare the composition and the resulting antioxidant as well as biological properties [on melanocytes and melanoma cells] of summer, savory growing in botanical garden of Vytautas Magnus University in middle Lithuania climatic conditions, collected during various phases of vegetation. It has been shown that the budding phase alcohol extract of this plant contains the largest amounts of polyphenols, including rutin and rosemary acid, which promote the radical scavenging activity and antioxidant properties. In contrast, the extract from the massive flowering phase already at a concentration of 12.5 µg/mL reduces the survival of melanoma cells to 60% with 90% melanocytes survival. In addition, extracts from beginning of flowering and end of flowering at a concentration of 25 µg/mL, containing significantly less rutin and rosmarinic acid, in combination with irradiation of cells with UVB, significantly increased the lipid peroxidation process, particularly in melanoma cells. These data indicate the possibility of using extracts from S. hortensis L. to modulate/differentiate the metabolism of normal and tumor skin cells. MDPI 2021-01-05 /pmc/articles/PMC7824789/ /pubmed/33466256 http://dx.doi.org/10.3390/antiox10010053 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bimbiraitė-Survilienė, Kristina
Stankevičius, Mantas
Šuštauskaitė, Simona
Gęgotek, Agnieszka
Maruška, Audrius
Skrzydlewska, Elżbieta
Barsteigienė, Zita
Akuņeca, Ieva
Ragažinskienė, Ona
Lukošius, Audronis
Evaluation of Chemical Composition, Radical Scavenging and Antitumor Activities of Satureja hortensis L. Herb Extracts
title Evaluation of Chemical Composition, Radical Scavenging and Antitumor Activities of Satureja hortensis L. Herb Extracts
title_full Evaluation of Chemical Composition, Radical Scavenging and Antitumor Activities of Satureja hortensis L. Herb Extracts
title_fullStr Evaluation of Chemical Composition, Radical Scavenging and Antitumor Activities of Satureja hortensis L. Herb Extracts
title_full_unstemmed Evaluation of Chemical Composition, Radical Scavenging and Antitumor Activities of Satureja hortensis L. Herb Extracts
title_short Evaluation of Chemical Composition, Radical Scavenging and Antitumor Activities of Satureja hortensis L. Herb Extracts
title_sort evaluation of chemical composition, radical scavenging and antitumor activities of satureja hortensis l. herb extracts
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824789/
https://www.ncbi.nlm.nih.gov/pubmed/33466256
http://dx.doi.org/10.3390/antiox10010053
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