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Lack of Antibodies to SARS-CoV-2 among Blood Donors during COVID-19 Lockdown: A Study from Saudi Arabia

In response to the coronavirus disease 2019 (COVID-19), Saudi Arabia have imposed timely restrictions to minimize the infection spread, lower the risk for vulnerable groups, and reduce the pressure on healthcare services. The effectiveness of these measures has not been assessed comprehensively and,...

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Autores principales: Alandijany, Thamir A., El-Kafrawy, Sherif A., Al-Ghamdi, Abrar A., Qashqari, Fadi S., Faizo, Arwa A., Tolah, Ahmed M., Hassan, Ahmed M., Sohrab, Sayed S., Hindawi, Salwa I., Badawi, Maha A., Azhar, Esam I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824813/
https://www.ncbi.nlm.nih.gov/pubmed/33466554
http://dx.doi.org/10.3390/healthcare9010051
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author Alandijany, Thamir A.
El-Kafrawy, Sherif A.
Al-Ghamdi, Abrar A.
Qashqari, Fadi S.
Faizo, Arwa A.
Tolah, Ahmed M.
Hassan, Ahmed M.
Sohrab, Sayed S.
Hindawi, Salwa I.
Badawi, Maha A.
Azhar, Esam I.
author_facet Alandijany, Thamir A.
El-Kafrawy, Sherif A.
Al-Ghamdi, Abrar A.
Qashqari, Fadi S.
Faizo, Arwa A.
Tolah, Ahmed M.
Hassan, Ahmed M.
Sohrab, Sayed S.
Hindawi, Salwa I.
Badawi, Maha A.
Azhar, Esam I.
author_sort Alandijany, Thamir A.
collection PubMed
description In response to the coronavirus disease 2019 (COVID-19), Saudi Arabia have imposed timely restrictions to minimize the infection spread, lower the risk for vulnerable groups, and reduce the pressure on healthcare services. The effectiveness of these measures has not been assessed comprehensively and, thereby, remains uncertain. Besides monitoring the number of COVID-19 cases diagnosed by molecular assays, the seroprevalence can serve as an indicator for the incidence rate among the general population. This study aimed to evaluate seroprevalence status of all healthy blood donors who attended one of the main largest hospital located in the western region of Saudi Arabia from 1 January to 31 May 2020. The study period covered two months prior to reporting the first COVID-19 case in the country on 2 March 2020. Importantly, it covered the period when “lock-down type” measures have been enforced. Samples were subjected to in-house enzyme-linked immunosorbent assay (ELISA), chemiluminescence immunoassay (CLIA), and microneutralization (MN). The sero statuses of all samples were confirmed negative, demonstrating the lack of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among blood donors during COVID-19 lockdown period. This study supports the hypothesis that COVID-19 restrictions have potential for limiting the extent of the infection.
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spelling pubmed-78248132021-01-24 Lack of Antibodies to SARS-CoV-2 among Blood Donors during COVID-19 Lockdown: A Study from Saudi Arabia Alandijany, Thamir A. El-Kafrawy, Sherif A. Al-Ghamdi, Abrar A. Qashqari, Fadi S. Faizo, Arwa A. Tolah, Ahmed M. Hassan, Ahmed M. Sohrab, Sayed S. Hindawi, Salwa I. Badawi, Maha A. Azhar, Esam I. Healthcare (Basel) Article In response to the coronavirus disease 2019 (COVID-19), Saudi Arabia have imposed timely restrictions to minimize the infection spread, lower the risk for vulnerable groups, and reduce the pressure on healthcare services. The effectiveness of these measures has not been assessed comprehensively and, thereby, remains uncertain. Besides monitoring the number of COVID-19 cases diagnosed by molecular assays, the seroprevalence can serve as an indicator for the incidence rate among the general population. This study aimed to evaluate seroprevalence status of all healthy blood donors who attended one of the main largest hospital located in the western region of Saudi Arabia from 1 January to 31 May 2020. The study period covered two months prior to reporting the first COVID-19 case in the country on 2 March 2020. Importantly, it covered the period when “lock-down type” measures have been enforced. Samples were subjected to in-house enzyme-linked immunosorbent assay (ELISA), chemiluminescence immunoassay (CLIA), and microneutralization (MN). The sero statuses of all samples were confirmed negative, demonstrating the lack of antibodies to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among blood donors during COVID-19 lockdown period. This study supports the hypothesis that COVID-19 restrictions have potential for limiting the extent of the infection. MDPI 2021-01-05 /pmc/articles/PMC7824813/ /pubmed/33466554 http://dx.doi.org/10.3390/healthcare9010051 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alandijany, Thamir A.
El-Kafrawy, Sherif A.
Al-Ghamdi, Abrar A.
Qashqari, Fadi S.
Faizo, Arwa A.
Tolah, Ahmed M.
Hassan, Ahmed M.
Sohrab, Sayed S.
Hindawi, Salwa I.
Badawi, Maha A.
Azhar, Esam I.
Lack of Antibodies to SARS-CoV-2 among Blood Donors during COVID-19 Lockdown: A Study from Saudi Arabia
title Lack of Antibodies to SARS-CoV-2 among Blood Donors during COVID-19 Lockdown: A Study from Saudi Arabia
title_full Lack of Antibodies to SARS-CoV-2 among Blood Donors during COVID-19 Lockdown: A Study from Saudi Arabia
title_fullStr Lack of Antibodies to SARS-CoV-2 among Blood Donors during COVID-19 Lockdown: A Study from Saudi Arabia
title_full_unstemmed Lack of Antibodies to SARS-CoV-2 among Blood Donors during COVID-19 Lockdown: A Study from Saudi Arabia
title_short Lack of Antibodies to SARS-CoV-2 among Blood Donors during COVID-19 Lockdown: A Study from Saudi Arabia
title_sort lack of antibodies to sars-cov-2 among blood donors during covid-19 lockdown: a study from saudi arabia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824813/
https://www.ncbi.nlm.nih.gov/pubmed/33466554
http://dx.doi.org/10.3390/healthcare9010051
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