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Recent Advances in Monoclonal Antibody Therapy for Colorectal Cancers
Colorectal cancer (CRC) is one of the leading causes of cancer deaths worldwide. Recent advances in recombinant DNA technology have led to the development of numerous therapeutic antibodies as major sources of blockbuster drugs for CRC therapy. Simultaneously, increasing numbers of therapeutic targe...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824816/ https://www.ncbi.nlm.nih.gov/pubmed/33466394 http://dx.doi.org/10.3390/biomedicines9010039 |
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author | Hwang, Kyusang Yoon, Jin Hwan Lee, Ji Hyun Lee, Sukmook |
author_facet | Hwang, Kyusang Yoon, Jin Hwan Lee, Ji Hyun Lee, Sukmook |
author_sort | Hwang, Kyusang |
collection | PubMed |
description | Colorectal cancer (CRC) is one of the leading causes of cancer deaths worldwide. Recent advances in recombinant DNA technology have led to the development of numerous therapeutic antibodies as major sources of blockbuster drugs for CRC therapy. Simultaneously, increasing numbers of therapeutic targets in CRC have been identified. In this review, we first highlight the physiological and pathophysiological roles and signaling mechanisms of currently known and emerging therapeutic targets, including growth factors and their receptors as well as immune checkpoint proteins, in CRC. Additionally, we discuss the current status of monoclonal antibodies in clinical development and approved by US Food and Drug Administration for CRC therapy. |
format | Online Article Text |
id | pubmed-7824816 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78248162021-01-24 Recent Advances in Monoclonal Antibody Therapy for Colorectal Cancers Hwang, Kyusang Yoon, Jin Hwan Lee, Ji Hyun Lee, Sukmook Biomedicines Review Colorectal cancer (CRC) is one of the leading causes of cancer deaths worldwide. Recent advances in recombinant DNA technology have led to the development of numerous therapeutic antibodies as major sources of blockbuster drugs for CRC therapy. Simultaneously, increasing numbers of therapeutic targets in CRC have been identified. In this review, we first highlight the physiological and pathophysiological roles and signaling mechanisms of currently known and emerging therapeutic targets, including growth factors and their receptors as well as immune checkpoint proteins, in CRC. Additionally, we discuss the current status of monoclonal antibodies in clinical development and approved by US Food and Drug Administration for CRC therapy. MDPI 2021-01-05 /pmc/articles/PMC7824816/ /pubmed/33466394 http://dx.doi.org/10.3390/biomedicines9010039 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Hwang, Kyusang Yoon, Jin Hwan Lee, Ji Hyun Lee, Sukmook Recent Advances in Monoclonal Antibody Therapy for Colorectal Cancers |
title | Recent Advances in Monoclonal Antibody Therapy for Colorectal Cancers |
title_full | Recent Advances in Monoclonal Antibody Therapy for Colorectal Cancers |
title_fullStr | Recent Advances in Monoclonal Antibody Therapy for Colorectal Cancers |
title_full_unstemmed | Recent Advances in Monoclonal Antibody Therapy for Colorectal Cancers |
title_short | Recent Advances in Monoclonal Antibody Therapy for Colorectal Cancers |
title_sort | recent advances in monoclonal antibody therapy for colorectal cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824816/ https://www.ncbi.nlm.nih.gov/pubmed/33466394 http://dx.doi.org/10.3390/biomedicines9010039 |
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