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Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings

Biofilms are surface-attached multicellular communities that play critical roles in inducing biofouling and biocorrosion in the marine environment. Given the serious economic losses and problems caused by biofouling and biocorrosion, effective biofilm control strategies are highly sought after. In a...

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Detalles Bibliográficos
Autores principales: Long, Lexin, Wang, Ruojun, Chiang, Ho Yin, Ding, Wei, Li, Yong-Xin, Chen, Feng, Qian, Pei-Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824865/
https://www.ncbi.nlm.nih.gov/pubmed/33466541
http://dx.doi.org/10.3390/md19010019
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author Long, Lexin
Wang, Ruojun
Chiang, Ho Yin
Ding, Wei
Li, Yong-Xin
Chen, Feng
Qian, Pei-Yuan
author_facet Long, Lexin
Wang, Ruojun
Chiang, Ho Yin
Ding, Wei
Li, Yong-Xin
Chen, Feng
Qian, Pei-Yuan
author_sort Long, Lexin
collection PubMed
description Biofilms are surface-attached multicellular communities that play critical roles in inducing biofouling and biocorrosion in the marine environment. Given the serious economic losses and problems caused by biofouling and biocorrosion, effective biofilm control strategies are highly sought after. In a screening program of antibiofilm compounds against marine biofilms, we discovered the potent biofilm inhibitory activity of elasnin. Elasnin effectively inhibited the biofilm formation of seven strains of bacteria isolated from marine biofilms. With high productivity, elasnin-based coatings were prepared in an easy and cost-effective way, which exhibited great performance in inhibiting the formation of multi-species biofilms and the attachment of large biofouling organisms in the marine environment. The 16S amplicon analysis and anti-larvae assay revealed that elasnin could prevent biofouling by the indirect impact of changed microbial composition of biofilms and direct inhibitory effect on larval settlement with low toxic effects. These findings indicated the potential application of elasnin in biofilm and biofouling control in the marine environment.
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spelling pubmed-78248652021-01-24 Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings Long, Lexin Wang, Ruojun Chiang, Ho Yin Ding, Wei Li, Yong-Xin Chen, Feng Qian, Pei-Yuan Mar Drugs Article Biofilms are surface-attached multicellular communities that play critical roles in inducing biofouling and biocorrosion in the marine environment. Given the serious economic losses and problems caused by biofouling and biocorrosion, effective biofilm control strategies are highly sought after. In a screening program of antibiofilm compounds against marine biofilms, we discovered the potent biofilm inhibitory activity of elasnin. Elasnin effectively inhibited the biofilm formation of seven strains of bacteria isolated from marine biofilms. With high productivity, elasnin-based coatings were prepared in an easy and cost-effective way, which exhibited great performance in inhibiting the formation of multi-species biofilms and the attachment of large biofouling organisms in the marine environment. The 16S amplicon analysis and anti-larvae assay revealed that elasnin could prevent biofouling by the indirect impact of changed microbial composition of biofilms and direct inhibitory effect on larval settlement with low toxic effects. These findings indicated the potential application of elasnin in biofilm and biofouling control in the marine environment. MDPI 2021-01-05 /pmc/articles/PMC7824865/ /pubmed/33466541 http://dx.doi.org/10.3390/md19010019 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Long, Lexin
Wang, Ruojun
Chiang, Ho Yin
Ding, Wei
Li, Yong-Xin
Chen, Feng
Qian, Pei-Yuan
Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings
title Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings
title_full Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings
title_fullStr Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings
title_full_unstemmed Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings
title_short Discovery of Antibiofilm Activity of Elasnin against Marine Biofilms and Its Application in the Marine Antifouling Coatings
title_sort discovery of antibiofilm activity of elasnin against marine biofilms and its application in the marine antifouling coatings
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7824865/
https://www.ncbi.nlm.nih.gov/pubmed/33466541
http://dx.doi.org/10.3390/md19010019
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