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Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women
Dynapenia is a key contributor to physical frailty. Cognitive impairment and dementia accompany frailty, yet links between skeletal muscle and neurocognition are poorly understood. We examined the cross-sectional relationship between lower limb muscle strength and global cognitive function. Particip...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825045/ https://www.ncbi.nlm.nih.gov/pubmed/33418963 http://dx.doi.org/10.3390/jcm10020173 |
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author | Pasco, Julie A. Stuart, Amanda L. Sui, Sophia X. Holloway-Kew, Kara L. Hyde, Natalie K. Tembo, Monica C. Rufus-Membere, Pamela Kotowicz, Mark A. Williams, Lana J. |
author_facet | Pasco, Julie A. Stuart, Amanda L. Sui, Sophia X. Holloway-Kew, Kara L. Hyde, Natalie K. Tembo, Monica C. Rufus-Membere, Pamela Kotowicz, Mark A. Williams, Lana J. |
author_sort | Pasco, Julie A. |
collection | PubMed |
description | Dynapenia is a key contributor to physical frailty. Cognitive impairment and dementia accompany frailty, yet links between skeletal muscle and neurocognition are poorly understood. We examined the cross-sectional relationship between lower limb muscle strength and global cognitive function. Participants were 127 women aged 51–87 years, from the Geelong Osteoporosis Study. Peak eccentric strength of the hip-flexors and hip abductors was determined using a hand-held dynamometer, and dynapenia identified as muscle strength t-scores < −1. Cognition was assessed using the Mini-Mental State Examination (MMSE), and MMSE scores below the median were rated as low. Associations between dynapenia and low cognition were examined using logistic regression models. Hip-flexor dynapenia was detected in 38 (71.7%) women with low cognition and 36 (48.7%) with good cognition (p = 0.009); for hip abductor dynapenia, the pattern was similar (21 (39.6%) vs. 9 (12.2%); p < 0.001). While the observed difference for hip-flexor strength was attenuated after adjusting for age and height (adjusted Odds Ratio (OR) 1.95, 95%CI 0.86–4.41), low cognition was nearly 4-fold more likely in association with hip abductor dynapenia (adjusted OR 3.76, 95%CI 1.44–9.83). No other confounders were identified. Our data suggest that low strength of the hip abductors and low cognition are associated and this could be a consequence of poor muscle function contributing to cognitive decline or vice versa. As muscle weakness is responsive to physical interventions, this warrants further investigation. |
format | Online Article Text |
id | pubmed-7825045 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78250452021-01-24 Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women Pasco, Julie A. Stuart, Amanda L. Sui, Sophia X. Holloway-Kew, Kara L. Hyde, Natalie K. Tembo, Monica C. Rufus-Membere, Pamela Kotowicz, Mark A. Williams, Lana J. J Clin Med Brief Report Dynapenia is a key contributor to physical frailty. Cognitive impairment and dementia accompany frailty, yet links between skeletal muscle and neurocognition are poorly understood. We examined the cross-sectional relationship between lower limb muscle strength and global cognitive function. Participants were 127 women aged 51–87 years, from the Geelong Osteoporosis Study. Peak eccentric strength of the hip-flexors and hip abductors was determined using a hand-held dynamometer, and dynapenia identified as muscle strength t-scores < −1. Cognition was assessed using the Mini-Mental State Examination (MMSE), and MMSE scores below the median were rated as low. Associations between dynapenia and low cognition were examined using logistic regression models. Hip-flexor dynapenia was detected in 38 (71.7%) women with low cognition and 36 (48.7%) with good cognition (p = 0.009); for hip abductor dynapenia, the pattern was similar (21 (39.6%) vs. 9 (12.2%); p < 0.001). While the observed difference for hip-flexor strength was attenuated after adjusting for age and height (adjusted Odds Ratio (OR) 1.95, 95%CI 0.86–4.41), low cognition was nearly 4-fold more likely in association with hip abductor dynapenia (adjusted OR 3.76, 95%CI 1.44–9.83). No other confounders were identified. Our data suggest that low strength of the hip abductors and low cognition are associated and this could be a consequence of poor muscle function contributing to cognitive decline or vice versa. As muscle weakness is responsive to physical interventions, this warrants further investigation. MDPI 2021-01-06 /pmc/articles/PMC7825045/ /pubmed/33418963 http://dx.doi.org/10.3390/jcm10020173 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Brief Report Pasco, Julie A. Stuart, Amanda L. Sui, Sophia X. Holloway-Kew, Kara L. Hyde, Natalie K. Tembo, Monica C. Rufus-Membere, Pamela Kotowicz, Mark A. Williams, Lana J. Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women |
title | Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women |
title_full | Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women |
title_fullStr | Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women |
title_full_unstemmed | Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women |
title_short | Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women |
title_sort | dynapenia and low cognition: a cross-sectional association in postmenopausal women |
topic | Brief Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825045/ https://www.ncbi.nlm.nih.gov/pubmed/33418963 http://dx.doi.org/10.3390/jcm10020173 |
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