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Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women

Dynapenia is a key contributor to physical frailty. Cognitive impairment and dementia accompany frailty, yet links between skeletal muscle and neurocognition are poorly understood. We examined the cross-sectional relationship between lower limb muscle strength and global cognitive function. Particip...

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Autores principales: Pasco, Julie A., Stuart, Amanda L., Sui, Sophia X., Holloway-Kew, Kara L., Hyde, Natalie K., Tembo, Monica C., Rufus-Membere, Pamela, Kotowicz, Mark A., Williams, Lana J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825045/
https://www.ncbi.nlm.nih.gov/pubmed/33418963
http://dx.doi.org/10.3390/jcm10020173
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author Pasco, Julie A.
Stuart, Amanda L.
Sui, Sophia X.
Holloway-Kew, Kara L.
Hyde, Natalie K.
Tembo, Monica C.
Rufus-Membere, Pamela
Kotowicz, Mark A.
Williams, Lana J.
author_facet Pasco, Julie A.
Stuart, Amanda L.
Sui, Sophia X.
Holloway-Kew, Kara L.
Hyde, Natalie K.
Tembo, Monica C.
Rufus-Membere, Pamela
Kotowicz, Mark A.
Williams, Lana J.
author_sort Pasco, Julie A.
collection PubMed
description Dynapenia is a key contributor to physical frailty. Cognitive impairment and dementia accompany frailty, yet links between skeletal muscle and neurocognition are poorly understood. We examined the cross-sectional relationship between lower limb muscle strength and global cognitive function. Participants were 127 women aged 51–87 years, from the Geelong Osteoporosis Study. Peak eccentric strength of the hip-flexors and hip abductors was determined using a hand-held dynamometer, and dynapenia identified as muscle strength t-scores < −1. Cognition was assessed using the Mini-Mental State Examination (MMSE), and MMSE scores below the median were rated as low. Associations between dynapenia and low cognition were examined using logistic regression models. Hip-flexor dynapenia was detected in 38 (71.7%) women with low cognition and 36 (48.7%) with good cognition (p = 0.009); for hip abductor dynapenia, the pattern was similar (21 (39.6%) vs. 9 (12.2%); p < 0.001). While the observed difference for hip-flexor strength was attenuated after adjusting for age and height (adjusted Odds Ratio (OR) 1.95, 95%CI 0.86–4.41), low cognition was nearly 4-fold more likely in association with hip abductor dynapenia (adjusted OR 3.76, 95%CI 1.44–9.83). No other confounders were identified. Our data suggest that low strength of the hip abductors and low cognition are associated and this could be a consequence of poor muscle function contributing to cognitive decline or vice versa. As muscle weakness is responsive to physical interventions, this warrants further investigation.
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spelling pubmed-78250452021-01-24 Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women Pasco, Julie A. Stuart, Amanda L. Sui, Sophia X. Holloway-Kew, Kara L. Hyde, Natalie K. Tembo, Monica C. Rufus-Membere, Pamela Kotowicz, Mark A. Williams, Lana J. J Clin Med Brief Report Dynapenia is a key contributor to physical frailty. Cognitive impairment and dementia accompany frailty, yet links between skeletal muscle and neurocognition are poorly understood. We examined the cross-sectional relationship between lower limb muscle strength and global cognitive function. Participants were 127 women aged 51–87 years, from the Geelong Osteoporosis Study. Peak eccentric strength of the hip-flexors and hip abductors was determined using a hand-held dynamometer, and dynapenia identified as muscle strength t-scores < −1. Cognition was assessed using the Mini-Mental State Examination (MMSE), and MMSE scores below the median were rated as low. Associations between dynapenia and low cognition were examined using logistic regression models. Hip-flexor dynapenia was detected in 38 (71.7%) women with low cognition and 36 (48.7%) with good cognition (p = 0.009); for hip abductor dynapenia, the pattern was similar (21 (39.6%) vs. 9 (12.2%); p < 0.001). While the observed difference for hip-flexor strength was attenuated after adjusting for age and height (adjusted Odds Ratio (OR) 1.95, 95%CI 0.86–4.41), low cognition was nearly 4-fold more likely in association with hip abductor dynapenia (adjusted OR 3.76, 95%CI 1.44–9.83). No other confounders were identified. Our data suggest that low strength of the hip abductors and low cognition are associated and this could be a consequence of poor muscle function contributing to cognitive decline or vice versa. As muscle weakness is responsive to physical interventions, this warrants further investigation. MDPI 2021-01-06 /pmc/articles/PMC7825045/ /pubmed/33418963 http://dx.doi.org/10.3390/jcm10020173 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Pasco, Julie A.
Stuart, Amanda L.
Sui, Sophia X.
Holloway-Kew, Kara L.
Hyde, Natalie K.
Tembo, Monica C.
Rufus-Membere, Pamela
Kotowicz, Mark A.
Williams, Lana J.
Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women
title Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women
title_full Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women
title_fullStr Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women
title_full_unstemmed Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women
title_short Dynapenia and Low Cognition: A Cross-Sectional Association in Postmenopausal Women
title_sort dynapenia and low cognition: a cross-sectional association in postmenopausal women
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825045/
https://www.ncbi.nlm.nih.gov/pubmed/33418963
http://dx.doi.org/10.3390/jcm10020173
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