The Mitochondrial Permeability Transition: Nexus of Aging, Disease and Longevity

The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-component mega-channel, is enhanced in aging and in aging-driven degenerative diseases. mPTP activity accelerates aging by releasing large amounts of cell-damaging reactive oxygen species, Ca(2+) and NAD(+...

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Detalles Bibliográficos
Autores principales: Rottenberg, Hagai, Hoek, Jan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825081/
https://www.ncbi.nlm.nih.gov/pubmed/33418876
http://dx.doi.org/10.3390/cells10010079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825081/
https://www.ncbi.nlm.nih.gov/pubmed/33418876
http://dx.doi.org/10.3390/cells10010079

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