Cargando…

The Mitochondrial Permeability Transition: Nexus of Aging, Disease and Longevity

The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-component mega-channel, is enhanced in aging and in aging-driven degenerative diseases. mPTP activity accelerates aging by releasing large amounts of cell-damaging reactive oxygen species, Ca(2+) and NAD(+...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rottenberg, Hagai, Hoek, Jan B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825081/ https://www.ncbi.nlm.nih.gov/pubmed/33418876 http://dx.doi.org/10.3390/cells10010079

Ejemplares similares

The path from mitochondrial ROS to aging runs through the mitochondrial permeability transition pore
por: Rottenberg, Hagai, et al.
Publicado: (2017)

The Reduction in the Mitochondrial Membrane Potential in Aging: The Role of the Mitochondrial Permeability Transition Pore
por: Rottenberg, Hagai
Publicado: (2023)

Aging Enhances the Activation of the Permeability Transition Pore in Mitochondria
por: Rottenberg, Hagai, et al.
Publicado: (2001)

The Mitochondrial Permeability Transition in Mitochondrial Disorders
por: Šileikytė, Justina, et al.
Publicado: (2019)

Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease
por: Jia, Kun, et al.
Publicado: (2021)

Mitochondrial Permeability Transition
por: Bernardi, Paolo, et al.
Publicado: (2022)

Normalized lifespan inequality: disentangling the longevity–lifespan variability nexus
por: Permanyer, Iñaki, et al.
Publicado: (2022)

The Role of Adenine Nucleotide Translocase in the Mitochondrial Permeability Transition
por: Brustovetsky, Nickolay
Publicado: (2020)

A Nexus model of cellular transition in cancer
por: Yadav, Mukesh, et al.
Publicado: (2018)

Regulation of the mitochondrial permeability transition pore and its effects on aging
por: Pellegrino-Coppola, Damiano
Publicado: (2020)

Targeting the Mitochondrial Permeability Transition Pore to Prevent Age-Associated Cell Damage and Neurodegeneration
por: Kent, Andrew C., et al.
Publicado: (2021)

Mitochondrial Dysfunction and Permeability Transition in Neonatal Brain and Lung Injuries
por: S. Ten, Vadim, et al.
Publicado: (2021)

The mitochondrial permeability transition: Recent progress and open questions
por: Bernardi, Paolo, et al.
Publicado: (2021)

The mitochondrial permeability transition pore activates the mitochondrial unfolded protein response and promotes aging
por: Angeli, Suzanne, et al.
Publicado: (2021)

Mitochondrial dynamics and viral infections: A close nexus()
por: Khan, Mohsin, et al.
Publicado: (2015)

Mitochondrial stress signaling in longevity: A new role for mitochondrial function in aging
por: Hill, Shauna, et al.
Publicado: (2014)

The mitochondrial permeability transition pore and its adaptive responses in tumor cells
por: Rasola, Andrea, et al.
Publicado: (2014)

The Haves and Have-Nots: The Mitochondrial Permeability Transition Pore across Species
por: Frigo, Elena, et al.
Publicado: (2023)

Unlocking the Door to Neuronal Woes in Alzheimer’s Disease: Aβ and Mitochondrial Permeability Transition Pore
por: Du, Heng, et al.
Publicado: (2010)

Pathophysiology of ageing, longevity and age related diseases
por: Bürkle, Alexander, et al.
Publicado: (2007)

PTEN, Longevity and Age-Related Diseases
por: Tait, Izak S., et al.
Publicado: (2013)

Inhibition of the Mitochondrial Permeability Transition for Cytoprotection: Direct versus Indirect Mechanisms
por: Martel, Cécile, et al.
Publicado: (2012)

Cellular senescence: at the nexus between ageing and diabetes
por: Palmer, Allyson K., et al.
Publicado: (2019)

Molecular links between cellular senescence, longevity and age-related diseases – a systems biology perspective
por: Tacutu, Robi, et al.
Publicado: (2011)

Targeting the mitochondrial permeability transition pore in traumatic central nervous system injury
por: Springer, Joe E., et al.
Publicado: (2018)

Diabetes Mellitus, Mitochondrial Dysfunction and Ca(2+)-Dependent Permeability Transition Pore
por: Belosludtsev, Konstantin N., et al.
Publicado: (2020)

Longevity and aging
por: Kaeberlein, Matt
Publicado: (2013)

Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease
por: Quintanilla, Rodrigo A, et al.
Publicado: (2013)

Investigating the Mitochondrial Permeability Transition Pore in Disease Phenotypes and Drug Screening
por: Bhosale, Gauri, et al.
Publicado: (2019)

Longevity, aging and rapamycin
por: Ehninger, Dan, et al.
Publicado: (2014)

Regulation of mitochondrial permeability transition pore by PINK1
por: Giaime, Emilie, et al.
Publicado: (2012)

The mitochondrial permeability transition pore: a mystery solved?
por: Bernardi, Paolo
Publicado: (2013)

Dual dynamics of mitochondrial permeability transition pore opening
por: Wacquier, Benjamin, et al.
Publicado: (2020)

The mitochondrial permeability transition pore: Molecular nature and role as a target in cardioprotection
por: Bernardi, Paolo, et al.
Publicado: (2015)

Mitochondrial permeability transition pore contributes to mitochondrial dysfunction in fibroblasts of patients with sporadic Alzheimer's disease
por: Pérez, María José, et al.
Publicado: (2018)

Making heads or tails of mitochondrial membranes in longevity and aging: a role for comparative studies
por: Valencak, Teresa G, et al.
Publicado: (2014)

Mitochondrial DNA Mutations Cause Disease, Apoptosis, and Permeability Transition Pore Dysfunction
por: Justin, L. Mott, et al.
Publicado: (2001)

Mitochondrial Dysfunction: At the Nexus between Alcohol-Associated Immunometabolic Dysregulation and Tissue Injury
por: Siggins, Robert W., et al.
Publicado: (2023)

The mitochondrial permeability transition pore is a dispensable element for mitochondrial calcium efflux
por: De Marchi, Elena, et al.
Publicado: (2014)

Cellular Senescence as the Causal Nexus of Aging
por: Bhatia-Dey, Naina, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_tdfr841ciomfgksk7afcqhd0o2