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Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes
The 1,3-butadiene motif is widely found in many natural products and drug candidates with relevant biological activities. Moreover, dienes are important targets for synthetic chemists, due to their ability to give access to a wide range of functional group transformations, including a broad range of...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825119/ https://www.ncbi.nlm.nih.gov/pubmed/33418882 http://dx.doi.org/10.3390/molecules26020249 |
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author | Soengas, Raquel G. Rodríguez-Solla, Humberto |
author_facet | Soengas, Raquel G. Rodríguez-Solla, Humberto |
author_sort | Soengas, Raquel G. |
collection | PubMed |
description | The 1,3-butadiene motif is widely found in many natural products and drug candidates with relevant biological activities. Moreover, dienes are important targets for synthetic chemists, due to their ability to give access to a wide range of functional group transformations, including a broad range of C-C bond-forming processes. Therefore, the stereoselective preparation of dienes have attracted much attention over the past decades, and the search for new synthetic protocols continues unabated. The aim of this review is to give an overview of the diverse methodologies that have emerged in the last decade, with a focus on the synthetic processes that meet the requirements of efficiency and sustainability of modern organic chemistry. |
format | Online Article Text |
id | pubmed-7825119 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-78251192021-01-24 Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes Soengas, Raquel G. Rodríguez-Solla, Humberto Molecules Review The 1,3-butadiene motif is widely found in many natural products and drug candidates with relevant biological activities. Moreover, dienes are important targets for synthetic chemists, due to their ability to give access to a wide range of functional group transformations, including a broad range of C-C bond-forming processes. Therefore, the stereoselective preparation of dienes have attracted much attention over the past decades, and the search for new synthetic protocols continues unabated. The aim of this review is to give an overview of the diverse methodologies that have emerged in the last decade, with a focus on the synthetic processes that meet the requirements of efficiency and sustainability of modern organic chemistry. MDPI 2021-01-06 /pmc/articles/PMC7825119/ /pubmed/33418882 http://dx.doi.org/10.3390/molecules26020249 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Soengas, Raquel G. Rodríguez-Solla, Humberto Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes |
title | Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes |
title_full | Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes |
title_fullStr | Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes |
title_full_unstemmed | Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes |
title_short | Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes |
title_sort | modern synthetic methods for the stereoselective construction of 1,3-dienes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825119/ https://www.ncbi.nlm.nih.gov/pubmed/33418882 http://dx.doi.org/10.3390/molecules26020249 |
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