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Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes

The 1,3-butadiene motif is widely found in many natural products and drug candidates with relevant biological activities. Moreover, dienes are important targets for synthetic chemists, due to their ability to give access to a wide range of functional group transformations, including a broad range of...

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Detalles Bibliográficos
Autores principales: Soengas, Raquel G., Rodríguez-Solla, Humberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825119/
https://www.ncbi.nlm.nih.gov/pubmed/33418882
http://dx.doi.org/10.3390/molecules26020249
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author Soengas, Raquel G.
Rodríguez-Solla, Humberto
author_facet Soengas, Raquel G.
Rodríguez-Solla, Humberto
author_sort Soengas, Raquel G.
collection PubMed
description The 1,3-butadiene motif is widely found in many natural products and drug candidates with relevant biological activities. Moreover, dienes are important targets for synthetic chemists, due to their ability to give access to a wide range of functional group transformations, including a broad range of C-C bond-forming processes. Therefore, the stereoselective preparation of dienes have attracted much attention over the past decades, and the search for new synthetic protocols continues unabated. The aim of this review is to give an overview of the diverse methodologies that have emerged in the last decade, with a focus on the synthetic processes that meet the requirements of efficiency and sustainability of modern organic chemistry.
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spelling pubmed-78251192021-01-24 Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes Soengas, Raquel G. Rodríguez-Solla, Humberto Molecules Review The 1,3-butadiene motif is widely found in many natural products and drug candidates with relevant biological activities. Moreover, dienes are important targets for synthetic chemists, due to their ability to give access to a wide range of functional group transformations, including a broad range of C-C bond-forming processes. Therefore, the stereoselective preparation of dienes have attracted much attention over the past decades, and the search for new synthetic protocols continues unabated. The aim of this review is to give an overview of the diverse methodologies that have emerged in the last decade, with a focus on the synthetic processes that meet the requirements of efficiency and sustainability of modern organic chemistry. MDPI 2021-01-06 /pmc/articles/PMC7825119/ /pubmed/33418882 http://dx.doi.org/10.3390/molecules26020249 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Soengas, Raquel G.
Rodríguez-Solla, Humberto
Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes
title Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes
title_full Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes
title_fullStr Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes
title_full_unstemmed Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes
title_short Modern Synthetic Methods for the Stereoselective Construction of 1,3-Dienes
title_sort modern synthetic methods for the stereoselective construction of 1,3-dienes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825119/
https://www.ncbi.nlm.nih.gov/pubmed/33418882
http://dx.doi.org/10.3390/molecules26020249
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