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Leronlimab, a humanized monoclonal antibody to CCR5, blocks breast cancer cellular metastasis and enhances cell death induced by DNA damaging chemotherapy

BACKGROUND: Triple-negative breast cancer (BCa) (TNBC) is a deadly form of human BCa with limited treatment options and poor prognosis. In our prior analysis of over 2200 breast cancer samples, the G protein-coupled receptor CCR5 was expressed in > 95% of TNBC samples. A humanized monoclonal anti...

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Detalles Bibliográficos
Autores principales:	Jiao, Xuanmao, Wang, Min, Zhang, Zhao, Li, Zhiping, Ni, Dong, Ashton, Anthony W., Tang, Hsin-Yao, Speicher, David W., Pestell, Richard G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825185/ https://www.ncbi.nlm.nih.gov/pubmed/33485378 http://dx.doi.org/10.1186/s13058-021-01391-1

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