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Quantitative Assessment of Levonorgestrel Binding Partner Interplay and Drug‐Drug Interactions Using Physiologically Based Pharmacokinetic Modeling

Levonorgestrel (LNG) is the active moiety in many hormonal contraceptive formulations. It is typically coformulated with ethinyl estradiol (EE) to decrease intermenstrual bleeding. Due to its widespread use and CYP3A4‐mediated metabolism, there is concern regarding drug‐drug interactions (DDIs), par...

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Detalles Bibliográficos
Autores principales:	Cicali, Brian, Lingineni, Karthik, Cristofoletti, Rodrigo, Wendl, Thomas, Hoechel, Joachim, Wiesinger, Herbert, Chaturvedula, Ayyappa, Vozmediano, Valvanera, Schmidt, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825189/ https://www.ncbi.nlm.nih.gov/pubmed/33217171 http://dx.doi.org/10.1002/psp4.12572

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