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Thrombocytopenia induced by glycoprotein (GP) IIb-IIIa antagonists: about two cases

In this paper, we report two cases of induced thrombocytopenia after the infusion of glycoprotein (GP) IIb/IIIa receptors antagonists, following a coronary angioplasty. The first patient is a 65-year-old woman, admitted with acute coronary syndrome requiring percutaneous angioplasty with stenting. T...

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Autores principales: Abdeladim, Salma, Elharras, Mahassine, Elouarradi, Amal, Bensahi, Ilham, Oualim, Sara, Merzouk, Fatimazahra, Sabry, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The African Field Epidemiology Network 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825373/
https://www.ncbi.nlm.nih.gov/pubmed/33520078
http://dx.doi.org/10.11604/pamj.2021.38.9.27215
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author Abdeladim, Salma
Elharras, Mahassine
Elouarradi, Amal
Bensahi, Ilham
Oualim, Sara
Merzouk, Fatimazahra
Sabry, Mohamed
author_facet Abdeladim, Salma
Elharras, Mahassine
Elouarradi, Amal
Bensahi, Ilham
Oualim, Sara
Merzouk, Fatimazahra
Sabry, Mohamed
author_sort Abdeladim, Salma
collection PubMed
description In this paper, we report two cases of induced thrombocytopenia after the infusion of glycoprotein (GP) IIb/IIIa receptors antagonists, following a coronary angioplasty. The first patient is a 65-year-old woman, admitted with acute coronary syndrome requiring percutaneous angioplasty with stenting. The patient was given tirofiban + unfractionated heparin (UFH). Ten hours later, the patient revealed very severe thrombocytopenia and went into hemorrhagic shock (hematemesis and hematoma at the injection site). The patient was transfused with nine units of red blood cells (RBCs), 24 platelets pellets and 4 units of fresh frozen plasma (FFP). The second patient is a 76-year-old woman. She was admitted to hospital for acute coronary syndrome necessitating percutaneous angioplasty with stenting and a glycoprotein IIb/IIIa receptor antagonists, tirofiban + unfractionated (UFH). Four hours later, the patient presented with gingivorrhagia associated thrombocytopenia. She received six platelet pellets transfusion with well clinical and biological improvement. These two observations raise the significance of a close monitoring of platelet count after the initiation of GP IIb/IIIa antagonists infusion, which are sometimes responsible for life-threatening adverse events.
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spelling pubmed-78253732021-01-29 Thrombocytopenia induced by glycoprotein (GP) IIb-IIIa antagonists: about two cases Abdeladim, Salma Elharras, Mahassine Elouarradi, Amal Bensahi, Ilham Oualim, Sara Merzouk, Fatimazahra Sabry, Mohamed Pan Afr Med J Case Report In this paper, we report two cases of induced thrombocytopenia after the infusion of glycoprotein (GP) IIb/IIIa receptors antagonists, following a coronary angioplasty. The first patient is a 65-year-old woman, admitted with acute coronary syndrome requiring percutaneous angioplasty with stenting. The patient was given tirofiban + unfractionated heparin (UFH). Ten hours later, the patient revealed very severe thrombocytopenia and went into hemorrhagic shock (hematemesis and hematoma at the injection site). The patient was transfused with nine units of red blood cells (RBCs), 24 platelets pellets and 4 units of fresh frozen plasma (FFP). The second patient is a 76-year-old woman. She was admitted to hospital for acute coronary syndrome necessitating percutaneous angioplasty with stenting and a glycoprotein IIb/IIIa receptor antagonists, tirofiban + unfractionated (UFH). Four hours later, the patient presented with gingivorrhagia associated thrombocytopenia. She received six platelet pellets transfusion with well clinical and biological improvement. These two observations raise the significance of a close monitoring of platelet count after the initiation of GP IIb/IIIa antagonists infusion, which are sometimes responsible for life-threatening adverse events. The African Field Epidemiology Network 2021-01-05 /pmc/articles/PMC7825373/ /pubmed/33520078 http://dx.doi.org/10.11604/pamj.2021.38.9.27215 Text en Copyright: Salma Abdeladim et al. https://creativecommons.org/licenses/by/4.0 The Pan African Medical Journal (ISSN: 1937-8688). This is an Open Access article distributed under the terms of the Creative Commons Attribution International 4.0 License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Abdeladim, Salma
Elharras, Mahassine
Elouarradi, Amal
Bensahi, Ilham
Oualim, Sara
Merzouk, Fatimazahra
Sabry, Mohamed
Thrombocytopenia induced by glycoprotein (GP) IIb-IIIa antagonists: about two cases
title Thrombocytopenia induced by glycoprotein (GP) IIb-IIIa antagonists: about two cases
title_full Thrombocytopenia induced by glycoprotein (GP) IIb-IIIa antagonists: about two cases
title_fullStr Thrombocytopenia induced by glycoprotein (GP) IIb-IIIa antagonists: about two cases
title_full_unstemmed Thrombocytopenia induced by glycoprotein (GP) IIb-IIIa antagonists: about two cases
title_short Thrombocytopenia induced by glycoprotein (GP) IIb-IIIa antagonists: about two cases
title_sort thrombocytopenia induced by glycoprotein (gp) iib-iiia antagonists: about two cases
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825373/
https://www.ncbi.nlm.nih.gov/pubmed/33520078
http://dx.doi.org/10.11604/pamj.2021.38.9.27215
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