Cargando…

The Optimizing Background Infusion Mode Decreases Intravenous Patient-Controlled Analgesic Volume and Opioid Consumption Compared to Fixed-Rate Background Infusion in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled, Double-Blind Study

Background and objectives: The fixed-rate continuous background infusion mode with bolus dosing is a common modality for intravenous patient-controlled analgesia (PCA). However, some patients suffer from inadequate analgesia or opioid-related adverse effects due to the biphasic pattern of postoperat...

Descripción completa

Detalles Bibliográficos
Autores principales: Jung, Ki Tae, So, Keum Young, Kim, Seung Un, Kim, Sang Hun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825461/
https://www.ncbi.nlm.nih.gov/pubmed/33419086
http://dx.doi.org/10.3390/medicina57010042
_version_ 1783640314784776192
author Jung, Ki Tae
So, Keum Young
Kim, Seung Un
Kim, Sang Hun
author_facet Jung, Ki Tae
So, Keum Young
Kim, Seung Un
Kim, Sang Hun
author_sort Jung, Ki Tae
collection PubMed
description Background and objectives: The fixed-rate continuous background infusion mode with bolus dosing is a common modality for intravenous patient-controlled analgesia (PCA). However, some patients suffer from inadequate analgesia or opioid-related adverse effects due to the biphasic pattern of postoperative pain. Therefore, we investigated the postoperative analgesic efficacy of PCA using an optimizing background infusion mode (OBIM) where the background injection rate varies depending on the patient’s bolus demand. Materials and Methods: We prospectively enrolled 204 patients who underwent laparoscopic cholecystectomy in a randomized, controlled, double-blind study. Patients were allocated to either the optimizing (group OBIM) or the traditional background infusion group (group TBIM). The numeric rating scale (NRS) score for pain was evaluated at admission to and discharge from the recovery room, as well as at the 6th, 24th, and 48th postoperative hours. Data on bolus demand count, total infused volume, and background infusion rate were downloaded from the PCA device at 30-min intervals until the 48th postoperative hour. Results: The NRS score was not significantly different between groups throughout the postoperative period (p = 0.621), decreasing with time in both groups (p < 0.001). The bolus demand count was not significantly different between groups throughout (p = 0.756). The mean total cumulative infused PCA volume was lower in group OBIM (84.0 (95% confidence interval: 78.9−89.1) mL) than in group TBIM (102 (97.8−106.0) mL; p < 0.001). The total cumulative opioid dose in fentanyl equivalents, after converting sufentanil to fentanyl using an equipotential dose ratio, was lower in group OBIM (714.1 (647.4−780.9) μg) than in group TBIM (963.7 (870.5−1056.9) μg); p < 0.001). The background infusion rate was significantly different between groups throughout the study period (p < 0.001); it was higher in group OBIM than in group TBIM before the 12th postoperative hour and lower from the 18th to the 48th postoperative hour. Conclusions: The OBIM combined with bolus dosing reduces the cumulative PCA volume and opioid consumption compared to the TBIM combined with bolus dosing, while yielding comparable postoperative analgesia and bolus demand in patients undergoing laparoscopic cholecystectomy.
format Online
Article
Text
id pubmed-7825461
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-78254612021-01-24 The Optimizing Background Infusion Mode Decreases Intravenous Patient-Controlled Analgesic Volume and Opioid Consumption Compared to Fixed-Rate Background Infusion in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled, Double-Blind Study Jung, Ki Tae So, Keum Young Kim, Seung Un Kim, Sang Hun Medicina (Kaunas) Article Background and objectives: The fixed-rate continuous background infusion mode with bolus dosing is a common modality for intravenous patient-controlled analgesia (PCA). However, some patients suffer from inadequate analgesia or opioid-related adverse effects due to the biphasic pattern of postoperative pain. Therefore, we investigated the postoperative analgesic efficacy of PCA using an optimizing background infusion mode (OBIM) where the background injection rate varies depending on the patient’s bolus demand. Materials and Methods: We prospectively enrolled 204 patients who underwent laparoscopic cholecystectomy in a randomized, controlled, double-blind study. Patients were allocated to either the optimizing (group OBIM) or the traditional background infusion group (group TBIM). The numeric rating scale (NRS) score for pain was evaluated at admission to and discharge from the recovery room, as well as at the 6th, 24th, and 48th postoperative hours. Data on bolus demand count, total infused volume, and background infusion rate were downloaded from the PCA device at 30-min intervals until the 48th postoperative hour. Results: The NRS score was not significantly different between groups throughout the postoperative period (p = 0.621), decreasing with time in both groups (p < 0.001). The bolus demand count was not significantly different between groups throughout (p = 0.756). The mean total cumulative infused PCA volume was lower in group OBIM (84.0 (95% confidence interval: 78.9−89.1) mL) than in group TBIM (102 (97.8−106.0) mL; p < 0.001). The total cumulative opioid dose in fentanyl equivalents, after converting sufentanil to fentanyl using an equipotential dose ratio, was lower in group OBIM (714.1 (647.4−780.9) μg) than in group TBIM (963.7 (870.5−1056.9) μg); p < 0.001). The background infusion rate was significantly different between groups throughout the study period (p < 0.001); it was higher in group OBIM than in group TBIM before the 12th postoperative hour and lower from the 18th to the 48th postoperative hour. Conclusions: The OBIM combined with bolus dosing reduces the cumulative PCA volume and opioid consumption compared to the TBIM combined with bolus dosing, while yielding comparable postoperative analgesia and bolus demand in patients undergoing laparoscopic cholecystectomy. MDPI 2021-01-06 /pmc/articles/PMC7825461/ /pubmed/33419086 http://dx.doi.org/10.3390/medicina57010042 Text en © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jung, Ki Tae
So, Keum Young
Kim, Seung Un
Kim, Sang Hun
The Optimizing Background Infusion Mode Decreases Intravenous Patient-Controlled Analgesic Volume and Opioid Consumption Compared to Fixed-Rate Background Infusion in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled, Double-Blind Study
title The Optimizing Background Infusion Mode Decreases Intravenous Patient-Controlled Analgesic Volume and Opioid Consumption Compared to Fixed-Rate Background Infusion in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled, Double-Blind Study
title_full The Optimizing Background Infusion Mode Decreases Intravenous Patient-Controlled Analgesic Volume and Opioid Consumption Compared to Fixed-Rate Background Infusion in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled, Double-Blind Study
title_fullStr The Optimizing Background Infusion Mode Decreases Intravenous Patient-Controlled Analgesic Volume and Opioid Consumption Compared to Fixed-Rate Background Infusion in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled, Double-Blind Study
title_full_unstemmed The Optimizing Background Infusion Mode Decreases Intravenous Patient-Controlled Analgesic Volume and Opioid Consumption Compared to Fixed-Rate Background Infusion in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled, Double-Blind Study
title_short The Optimizing Background Infusion Mode Decreases Intravenous Patient-Controlled Analgesic Volume and Opioid Consumption Compared to Fixed-Rate Background Infusion in Patients Undergoing Laparoscopic Cholecystectomy: A Prospective, Randomized, Controlled, Double-Blind Study
title_sort optimizing background infusion mode decreases intravenous patient-controlled analgesic volume and opioid consumption compared to fixed-rate background infusion in patients undergoing laparoscopic cholecystectomy: a prospective, randomized, controlled, double-blind study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825461/
https://www.ncbi.nlm.nih.gov/pubmed/33419086
http://dx.doi.org/10.3390/medicina57010042
work_keys_str_mv AT jungkitae theoptimizingbackgroundinfusionmodedecreasesintravenouspatientcontrolledanalgesicvolumeandopioidconsumptioncomparedtofixedratebackgroundinfusioninpatientsundergoinglaparoscopiccholecystectomyaprospectiverandomizedcontrolleddoubleblindstudy
AT sokeumyoung theoptimizingbackgroundinfusionmodedecreasesintravenouspatientcontrolledanalgesicvolumeandopioidconsumptioncomparedtofixedratebackgroundinfusioninpatientsundergoinglaparoscopiccholecystectomyaprospectiverandomizedcontrolleddoubleblindstudy
AT kimseungun theoptimizingbackgroundinfusionmodedecreasesintravenouspatientcontrolledanalgesicvolumeandopioidconsumptioncomparedtofixedratebackgroundinfusioninpatientsundergoinglaparoscopiccholecystectomyaprospectiverandomizedcontrolleddoubleblindstudy
AT kimsanghun theoptimizingbackgroundinfusionmodedecreasesintravenouspatientcontrolledanalgesicvolumeandopioidconsumptioncomparedtofixedratebackgroundinfusioninpatientsundergoinglaparoscopiccholecystectomyaprospectiverandomizedcontrolleddoubleblindstudy
AT jungkitae optimizingbackgroundinfusionmodedecreasesintravenouspatientcontrolledanalgesicvolumeandopioidconsumptioncomparedtofixedratebackgroundinfusioninpatientsundergoinglaparoscopiccholecystectomyaprospectiverandomizedcontrolleddoubleblindstudy
AT sokeumyoung optimizingbackgroundinfusionmodedecreasesintravenouspatientcontrolledanalgesicvolumeandopioidconsumptioncomparedtofixedratebackgroundinfusioninpatientsundergoinglaparoscopiccholecystectomyaprospectiverandomizedcontrolleddoubleblindstudy
AT kimseungun optimizingbackgroundinfusionmodedecreasesintravenouspatientcontrolledanalgesicvolumeandopioidconsumptioncomparedtofixedratebackgroundinfusioninpatientsundergoinglaparoscopiccholecystectomyaprospectiverandomizedcontrolleddoubleblindstudy
AT kimsanghun optimizingbackgroundinfusionmodedecreasesintravenouspatientcontrolledanalgesicvolumeandopioidconsumptioncomparedtofixedratebackgroundinfusioninpatientsundergoinglaparoscopiccholecystectomyaprospectiverandomizedcontrolleddoubleblindstudy