Molecular Mechanisms of Succinimide Formation from Aspartic Acid Residues Catalyzed by Two Water Molecules in the Aqueous Phase

Aspartic acid (Asp) residues are prone to nonenzymatic isomerization via a succinimide (Suc) intermediate. The formation of isomerized Asp residues is considered to be associated with various age-related diseases, such as cataracts and Alzheimer’s disease. In the present paper, we describe the react...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakayoshi, Tomoki, Kato, Koichi, Fukuyoshi, Shuichi, Takahashi, Ohgi, Kurimoto, Eiji, Oda, Akifumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825500/
https://www.ncbi.nlm.nih.gov/pubmed/33419172
http://dx.doi.org/10.3390/ijms22020509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7825500/
https://www.ncbi.nlm.nih.gov/pubmed/33419172
http://dx.doi.org/10.3390/ijms22020509

Ejemplares similares